Early telomerase inactivation accelerates aging independently of telomere length.

PubWeight™: 0.88‹?›

🔗 View Article (PMID 25723167)

Published in Cell on February 26, 2015

Authors

Zhengwei Xie1, Kyle A Jay2, Dana L Smith2, Yi Zhang1, Zairan Liu1, Jiashun Zheng3, Ruilin Tian4, Hao Li5, Elizabeth H Blackburn6

Author Affiliations

1: Center for Quantitative Biology, School of Physics and The Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
2: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
3: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
4: Center for Quantitative Biology, School of Physics and The Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
5: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: haoli@genome.ucsf.edu.
6: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: elizabeth.blackburn@ucsf.edu.

Articles citing this

The crosstalk of telomere dysfunction and inflammation through cell-free TERRA containing exosomes. RNA Biol (2016) 0.85

How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative. Cold Spring Harb Perspect Med (2016) 0.83

Microfluidic technologies for yeast replicative lifespan studies. Mech Ageing Dev (2016) 0.81

Association of peripheral leukocyte telomere length and its variation with pancreatic cancer and colorectal cancer risk in Chinese population. Oncotarget (2016) 0.81

Identification of novel noncoding transcripts in telomerase-negative yeast using RNA-seq. Sci Rep (2016) 0.78

The Natural Variation in Lifespans of Single Yeast Cells Is Related to Variation in Cell Size, Ribosomal Protein, and Division Time. PLoS One (2016) 0.77

Sensing telomerase: From in vitro detection to in vivo imaging. Chem Sci (2016) 0.76

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence. Biol Res (2016) 0.75

The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain. Oncotarget (2016) 0.75

Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins. Mol Cell Biol (2016) 0.75

Telomere Length and Coronary Atherosclerosis in Rheumatoid Arthritis. J Rheumatol (2016) 0.75

Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex? Front Immunol (2017) 0.75

Articles cited by this

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res (2002) 76.95

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43

A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55

Reverse transcriptase motifs in the catalytic subunit of telomerase. Science (1997) 10.10

A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol Cell (1998) 7.16

An alternative pathway for yeast telomere maintenance rescues est1- senescence. Cell (1993) 6.89

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell (2009) 5.74

Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat Cell Biol (2001) 5.05

Interactions between deoxyribonucleotide and DNA synthesis. Annu Rev Biochem (1988) 4.79

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell (1999) 4.71

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell (1995) 4.20

The telomere syndromes. Nat Rev Genet (2012) 4.01

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase. Cell (2003) 3.91

Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell (1999) 3.62

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev (2003) 3.59

Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet (2007) 3.59

Molecular biology of aging. Cell (1999) 3.08

Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A (1986) 3.05

Lessons on longevity from budding yeast. Nature (2010) 2.81

Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Mol Cell (2003) 2.78

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev (1996) 2.76

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature (2014) 2.67

Semi-conservative DNA replication through telomeres requires Taz1. Nature (2006) 2.53

Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae. Mol Cell Biol (1999) 1.99

Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo. Mol Cell (2004) 1.91

Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes Dev (2004) 1.67

DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae. Free Radic Biol Med (2008) 1.40

Biological consequences of oxidative stress-induced DNA damage in Saccharomyces cerevisiae. Nucleic Acids Res (2004) 1.32

The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2002) 1.27

ATM-like kinases and regulation of telomerase: lessons from yeast and mammals. Trends Cell Biol (2008) 1.22

Molecular phenotyping of aging in single yeast cells using a novel microfluidic device. Aging Cell (2012) 1.22

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage. Nucleic Acids Res (2010) 1.12

Single cell analysis of yeast replicative aging using a new generation of microfluidic device. PLoS One (2012) 1.11

Human telomeres replicate using chromosome-specific, rather than universal, replication programs. J Cell Biol (2012) 1.08

Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1. DNA Repair (Amst) (2007) 1.02

The DNA damage checkpoint response to replication stress: A Game of Forks. Front Genet (2013) 0.94

Activation of Mrc1, a mediator of the replication checkpoint, by telomere erosion. Biol Cell (2005) 0.92

Telomerase is essential to alleviate pif1-induced replication stress at telomeres. Genetics (2009) 0.90

Recombination can either help maintain very short telomeres or generate longer telomeres in yeast cells with weak telomerase activity. Eukaryot Cell (2011) 0.79