Published in Mol Cell on May 01, 2003
Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A (2004) 12.89
Telomeres and telomerase. Philos Trans R Soc Lond B Biol Sci (2004) 3.13
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY) (2008) 2.35
Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood. Proc Natl Acad Sci U S A (2011) 1.88
Rap1 prevents telomere fusions by nonhomologous end joining. EMBO J (2005) 1.87
Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial. Brain Behav Immun (2012) 1.76
DNA damage response at functional and dysfunctional telomeres. Genes Dev (2008) 1.75
Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining. EMBO J (2004) 1.72
Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell (2007) 1.56
DNA breaks are masked by multiple Rap1 binding in yeast: implications for telomere capping and telomerase regulation. Genes Dev (2007) 1.45
Multiple pathways inhibit NHEJ at telomeres. Genes Dev (2008) 1.40
Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres. Ann N Y Acad Sci (2009) 1.37
End resection initiates genomic instability in the absence of telomerase. Mol Cell Biol (2003) 1.32
Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. Genes Dev (2004) 1.30
Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.25
Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage. DNA Repair (Amst) (2009) 1.23
Telomeres: structures in need of unwinding. FEBS Lett (2010) 1.21
ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis. Genes Dev (2005) 1.16
Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2004) 1.16
Telomere dynamics and fusion of critically shortened telomeres in plants lacking DNA ligase IV. Nucleic Acids Res (2007) 1.15
Increased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints. Eukaryot Cell (2004) 1.14
Telomere capping in non-dividing yeast cells requires Yku and Rap1. EMBO J (2010) 1.12
Taming the tiger by the tail: modulation of DNA damage responses by telomeres. EMBO J (2009) 1.12
Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks. Chromosoma (2008) 1.10
Epigenetic telomere protection by Drosophila DNA damage response pathways. PLoS Genet (2006) 1.10
Mechanisms of chromosome number evolution in yeast. PLoS Genet (2011) 1.09
Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast. Mol Cell Biol (2007) 1.04
Telomerase core components protect Candida telomeres from aberrant overhang accumulation. Proc Natl Acad Sci U S A (2007) 1.01
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res (2008) 0.99
Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications. DNA Repair (Amst) (2008) 0.96
Kinase-independent functions of TEL1 in telomere maintenance. Mol Cell Biol (2009) 0.94
Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing. Curr Opin Genet Dev (2014) 0.93
The Rad1-Rad10 complex promotes the production of gross chromosomal rearrangements from spontaneous DNA damage in Saccharomyces cerevisiae. Genetics (2005) 0.93
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres. Proc Natl Acad Sci U S A (2006) 0.93
Dicentric breakage at telomere fusions. Genes Dev (2010) 0.92
An alternative telomerase RNA in Arabidopsis modulates enzyme activity in response to DNA damage. Genes Dev (2012) 0.92
Two roles for Rad50 in telomere maintenance. EMBO J (2006) 0.91
Prenatal stress, development, health and disease risk: A psychobiological perspective-2015 Curt Richter Award Paper. Psychoneuroendocrinology (2015) 0.91
High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans. Nucleic Acids Res (2006) 0.90
Telomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae. PLoS One (2008) 0.90
Early telomerase inactivation accelerates aging independently of telomere length. Cell (2015) 0.88
Modulation of telomere terminal structure by telomerase components in Candida albicans. Nucleic Acids Res (2006) 0.88
The role of nonhomologous end-joining components in telomere metabolism in Kluyveromyces lactis. Genetics (2007) 0.87
Characterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition site. J Biol Chem (2010) 0.86
Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres. Mol Cell Biol (2007) 0.86
DNA repair pathway selection caused by defects in TEL1, SAE2, and de novo telomere addition generates specific chromosomal rearrangement signatures. PLoS Genet (2014) 0.84
ZNF365 promotes stability of fragile sites and telomeres. Cancer Discov (2013) 0.83
Suppression of gross chromosomal rearrangements by yKu70-yKu80 heterodimer through DNA damage checkpoints. Proc Natl Acad Sci U S A (2006) 0.83
The paradoxical relationship between NHEJ and telomeric fusion. Mol Cell (2003) 0.83
Faithful after break-up: suppression of chromosomal translocations. Cell Mol Life Sci (2009) 0.82
ATM regulates the length of individual telomere tracts in Arabidopsis. Proc Natl Acad Sci U S A (2007) 0.81
Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. J Biomed Sci (2009) 0.80
Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening. Front Oncol (2013) 0.80
Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Res (2015) 0.79
Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells. Nucleic Acids Res (2013) 0.79
Mating type influences chromosome loss and replicative senescence in telomerase-deficient budding yeast by Dnl4-dependent telomere fusion. Mol Microbiol (2008) 0.78
A mutation in yeast Tel1p that causes differential effects on the DNA damage checkpoint and telomere maintenance. Curr Genet (2005) 0.78
How do telomeres and NHEJ coexist? Mol Cell Oncol (2014) 0.75
Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins. Mol Cell Biol (2016) 0.75
Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A (2004) 12.89
The telomere syndromes. Nat Rev Genet (2012) 4.01
Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A (2007) 3.67
Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol (2008) 3.57
Telomeres and telomerase. Philos Trans R Soc Lond B Biol Sci (2004) 3.13
Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology (2005) 3.08
New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene (2002) 2.46
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY) (2008) 2.35
Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings. PLoS One (2011) 2.30
DNA damage signalling prevents deleterious telomere addition at DNA breaks. Nat Cell Biol (2009) 2.05
A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev (2002) 1.95
Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A Biol Sci Med Sci (2009) 1.90
Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood. Proc Natl Acad Sci U S A (2011) 1.88
A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein. Proc Natl Acad Sci U S A (2004) 1.83
Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2002. Soc Sci Med (2013) 1.81
A molecular switch underlies a human telomerase disease. Proc Natl Acad Sci U S A (2002) 1.79
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS One (2011) 1.78
Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology (2010) 1.73
Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell (2009) 1.72
Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA (2010) 1.71
Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol (2004) 1.71
Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Mol Cell Biol (2004) 1.69
Dynamics of telomerase activity in response to acute psychological stress. Brain Behav Immun (2009) 1.68
Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res (2004) 1.66
Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length. Mol Cell Biol (2004) 1.66
Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell (2007) 1.56
A novel pseudoknot element is essential for the action of a yeast telomerase. Genes Dev (2003) 1.55
Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol (2013) 1.55
Comprehensive structure-function analysis of the core domain of human telomerase RNA. Mol Cell Biol (2003) 1.49
Visualization of actin filaments and monomers in somatic cell nuclei. Mol Biol Cell (2013) 1.40
Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita. Blood (2005) 1.37
Socioeconomic status and cell aging in children. Soc Sci Med (2012) 1.32
Genes and pathways downstream of telomerase in melanoma metastasis. Proc Natl Acad Sci U S A (2006) 1.27
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2002) 1.27
Shorter leukocyte telomere length in midlife women with poor sleep quality. J Aging Res (2011) 1.26
Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J Biol Chem (2005) 1.25
A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. RNA (2003) 1.24
Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length. Brain Behav Immun (2012) 1.22
Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev (2004) 1.21
A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase. Genes Dev (2003) 1.20
Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length. Am J Obstet Gynecol (2012) 1.16
Telomere shortening in formerly abused and never abused women. Biol Res Nurs (2011) 1.15
Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy. Epigenetics Chromatin (2008) 1.13
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. Genes Dev (2008) 1.12
Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination Surveys. Am J Public Health (2014) 1.10
Tracking telomerase. Cell (2004) 1.10
The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis. Cancer Res (2013) 1.04
Catalytically active human telomerase mutants with allele-specific biological properties. Exp Cell Res (2003) 1.02
Processive utilization of the human telomerase template: lack of a requirement for template switching. J Biol Chem (2004) 1.01
Telomerase core components protect Candida telomeres from aberrant overhang accumulation. Proc Natl Acad Sci U S A (2007) 1.01
Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002. Epidemiology (2015) 1.00
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res (2008) 0.99
Hostility and cellular aging in men from the Whitehall II cohort. Biol Psychiatry (2011) 0.99
Chronic stress elevates telomerase activity in rats. Biol Lett (2012) 0.98
Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use. PLoS One (2013) 0.98
Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response. Mol Biol Cell (2004) 0.97
Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA. Clin Cancer Res (2004) 0.97
Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources. Proc Natl Acad Sci U S A (2014) 0.97
Dynamics of telomeric DNA turnover in yeast. Genetics (2002) 0.95
A common variant in the telomerase RNA component is associated with short telomere length. PLoS One (2010) 0.95
Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Res (2006) 0.94
Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: a population-based study. Exp Gerontol (2013) 0.93
Associations of cadmium and lead exposure with leukocyte telomere length: findings from National Health and Nutrition Examination Survey, 1999-2002. Am J Epidemiol (2014) 0.91
An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells. Mol Cell Biol (2013) 0.90
The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase. Genetics (2008) 0.88
A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response. Mol Cell Biol (2008) 0.88
Multisystem resiliency moderates the major depression-telomere length association: findings from the Heart and Soul Study. Brain Behav Immun (2013) 0.87
Characterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition site. J Biol Chem (2010) 0.86
Unprecedented opportunities and promise for cancer prevention research. Cancer Prev Res (Phila) (2010) 0.86
The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion. Mol Cell (2010) 0.86
Maternal estriol concentrations in early gestation predict infant telomere length. J Clin Endocrinol Metab (2015) 0.85
Cytomegalovirus is associated with reduced telomerase activity in the Whitehall II cohort. Exp Gerontol (2013) 0.85
Maternal Folate Concentration in Early Pregnancy and Newborn Telomere Length. Ann Nutr Metab (2015) 0.85
Highlighting the science of cancer prevention. Cancer Prev Res (Phila) (2010) 0.82
Mec1 function in the DNA damage response does not require its interaction with Tel2. Cell Cycle (2008) 0.81
Seasonal variation of peripheral blood leukocyte telomere length in Costa Rica: A population-based observational study. Am J Hum Biol (2014) 0.81
Movement-Based Behaviors and Leukocyte Telomere Length among US Adults. Med Sci Sports Exerc (2015) 0.77
Cell biology: Shaggy mouse tales. Nature (2005) 0.77
A Trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity. J Biol Chem (2001) 0.76
Correction: Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. PLoS One (2016) 0.75
Actuary of the cell. Interview by Thea Singer. Sci Am (2011) 0.75