Published in Trends Endocrinol Metab on March 09, 2015
Estrogen Receptors and Peripheral Artery Disease (ESTROPAD) | NCT04419727
International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators. Pharmacol Rev (2015) 0.87
Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease. EBioMedicine (2016) 0.86
GPER/GPR30 Knockout Mice: Effects of GPER on Metabolism. Methods Mol Biol (2016) 0.84
Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis. Int J Endocrinol (2015) 0.79
GPER-novel membrane oestrogen receptor. Clin Sci (Lond) (2016) 0.78
GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells. Oncotarget (2015) 0.78
Obligatory role for GPER in cardiovascular aging and disease. Sci Signal (2016) 0.77
Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER. BMC Cancer (2015) 0.76
PAHs Target Hematopoietic Linages in Bone Marrow through Cyp1b1 Primarily in Mesenchymal Stromal Cells but Not AhR: A Reconstituted In Vitro Model. Stem Cells Int (2016) 0.75
Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives. J Steroid Biochem Mol Biol (2017) 0.75
GPER modulators: Opportunity Nox on the heels of a class Akt. J Steroid Biochem Mol Biol (2017) 0.75
Role of GPER in the activation of endothelial nitric oxide synthase. J Steroid Biochem Mol Biol (2017) 0.75
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science (2005) 9.80
Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol (2000) 5.53
Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol (2006) 5.20
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology (2004) 5.20
Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol (2002) 3.65
GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone. Hypertension (2011) 3.26
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol (2008) 3.20
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science (2002) 2.45
In vivo effects of a GPR30 antagonist. Nat Chem Biol (2009) 2.39
The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol (2011) 2.33
Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane. Endocrinology (2007) 2.29
Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function. Endocrinology (2014) 2.17
Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res (2009) 2.16
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology (2008) 2.09
Lessons in estrogen biology from knockout and transgenic animals. Annu Rev Physiol (2005) 1.99
Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. J Steroid Biochem Mol Biol (2002) 1.94
The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev (2013) 1.93
Antidiabetic actions of estrogen: insight from human and genetic mouse models. Curr Atheroscler Rep (2004) 1.80
G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane. Biochem Biophys Res Commun (2006) 1.79
G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol. Endocrinology (2008) 1.79
GPR30 contributes to estrogen-induced thymic atrophy. Mol Endocrinol (2007) 1.78
Estrogen receptors and the metabolic network. Cell Metab (2011) 1.70
GPR30 does not mediate estrogenic responses in reproductive organs in mice. Biol Reprod (2008) 1.67
GPR30 predicts poor survival for ovarian cancer. Gynecol Oncol (2009) 1.63
Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes. J Clin Invest (2011) 1.55
Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes (2009) 1.53
The pancreatic beta-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes. Mol Cell Endocrinol (2009) 1.53
The diversity of sex steroid action: regulation of metabolism by estrogen signaling. J Endocrinol (2011) 1.52
Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors. Acta Physiol (Oxf) (2011) 1.48
Importance of oestrogen receptors to preserve functional β-cell mass in diabetes. Nat Rev Endocrinol (2012) 1.47
Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. J Clin Invest (2001) 1.45
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Biochem Mol Biol (2011) 1.42
Minireview: Extranuclear steroid receptors: roles in modulation of cell functions. Mol Endocrinol (2010) 1.40
Oestrogens and insulin secretion. Diabetologia (2005) 1.38
The role of oestrogens in the adaptation of islets to insulin resistance. J Physiol (2009) 1.37
Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. ACS Chem Biol (2007) 1.37
Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice. Endocrinology (2008) 1.35
Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol (2009) 1.32
Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. Proc Natl Acad Sci U S A (2010) 1.28
A critical review of fundamental controversies in the field of GPR30 research. Steroids (2009) 1.27
GPR30/GPER1: searching for a role in estrogen physiology. Trends Endocrinol Metab (2009) 1.24
Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues. Biochem Biophys Res Commun (1996) 1.23
Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol (2014) 1.23
Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation. Neurosci Lett (2008) 1.19
The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function. Vascul Pharmacol (2011) 1.18
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity. J Clin Invest (2012) 1.17
Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nuclei. Endocrinology (2007) 1.17
Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30. J Med Chem (2010) 1.16
Retracted G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells. Environ Health Perspect (2008) 1.13
Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells. Endocrinology (2011) 1.12
Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis. Pflugers Arch (2010) 1.04
G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation. PLoS One (2012) 1.03
Perivascular visceral adipose tissue induces atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis (2011) 1.03
GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinology (2013) 1.03
Cholesterol and atherosclerosis: modulation by oestrogen. Curr Opin Lipidol (2013) 1.02
Insulin-like growth factor-I regulates GPER expression and function in cancer cells. Oncogene (2012) 1.00
MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells. Breast Cancer Res (2012) 1.00
GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast. Horm Cancer (2014) 0.99
GPER mediates activation of HIF1α/VEGF signaling by estrogens. Cancer Res (2014) 0.98
Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction. Hypertension (2011) 0.97
GPR30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice. J Bone Miner Res (2011) 0.95
Position paper: The membrane estrogen receptor GPER--Clues and questions. Steroids (2012) 0.95
GPR30, but not estrogen receptor-alpha, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol. BMC Immunol (2010) 0.95
The role of hypothalamic estrogen receptors in metabolic regulation. Front Neuroendocrinol (2014) 0.93
The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs). Mol Cell Endocrinol (2013) 0.92
G protein-coupled estrogen receptor agonist improves cerebral microvascular function after hypoxia/reoxygenation injury in male and female rats. Stroke (2013) 0.92
Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1. Immunology (2011) 0.92
2-methoxyestradiol binding of GPR30 down-regulates angiotensin AT(1) receptor. Eur J Pharmacol (2013) 0.92
Mechanisms of G protein-coupled estrogen receptor-mediated spinal nociception. J Pain (2012) 0.91
Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis. Horm Behav (2014) 0.91
Impaired left-ventricular cardiac function in male GPR30-deficient mice. Mol Med Rep (2010) 0.91
Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes. Diabetologia (2012) 0.90
GPR30/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages. Mol Cell Endocrinol (2010) 0.89
Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke. Stroke (2014) 0.88
G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth. Obstet Gynecol Int (2013) 0.88
Regulation of vascular smooth muscle tone by adipose-derived contracting factor. PLoS One (2013) 0.88
Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation. PLoS One (2013) 0.87
GPER regulates endothelin-dependent vascular tone and intracellular calcium. Life Sci (2012) 0.87
Niacin activates the G protein estrogen receptor (GPER)-mediated signalling. Cell Signal (2014) 0.87
International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators. Pharmacol Rev (2015) 0.87
G protein-coupled estrogen receptor protects from atherosclerosis. Sci Rep (2014) 0.86
ERalpha, ERbeta, and gpER: novel aspects of oestrogen receptor signalling in atherosclerosis. Cardiovasc Res (2009) 0.86
Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors. Arterioscler Thromb Vasc Biol (2014) 0.85
Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling. Steroids (2013) 0.85
The cardiovascular effects of selective estrogen receptor modulators. Ann N Y Acad Sci (2006) 0.85
Estrogenic endocrine-disrupting chemicals: molecular mechanisms of actions on putative human diseases. J Toxicol Environ Health B Crit Rev (2014) 0.85
17beta-estradiol prevents early-stage atherosclerosis in estrogen receptor-alpha deficient female mice. J Cardiovasc Transl Res (2009) 0.85
Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone. Mol Cell Endocrinol (2013) 0.85
G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis. Mol Cancer Res (2014) 0.85
Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils. Immunol Lett (2014) 0.84
GPR30 mediates estrogen rapid signaling and neuroprotection. Mol Cell Endocrinol (2014) 0.84
Stroke increases g protein-coupled estrogen receptor expression in the brain of male but not female mice. Neurosignals (2012) 0.83
GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts. Endocr Relat Cancer (2014) 0.83
Recent advances in the rationale design of GPER ligands. Curr Med Chem (2012) 0.83
The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions. J Immunother (2013) 0.82
Resveratrol inhibits K(v)2.2 currents through the estrogen receptor GPR30-mediated PKC pathway. Am J Physiol Cell Physiol (2013) 0.82
Functional selectivity in GPCR signaling: understanding the full spectrum of receptor conformations. Mini Rev Med Chem (2012) 0.81
Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30. PLoS One (2012) 0.81
Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents. ACS Chem Biol (2010) 0.81
Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol (2014) 1.23
Nicolaus Copernicus and the rapid vascular responses to aldosterone. Trends Endocrinol Metab (2015) 0.77