Published in PLoS One on December 20, 2012
G-protein-coupled estrogen receptor agonist suppresses airway inflammation in a mouse model of asthma through IL-10. PLoS One (2015) 1.42
Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol (2014) 1.23
Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis. Biochim Biophys Acta (2016) 0.92
2-methoxyestradiol binding of GPR30 down-regulates angiotensin AT(1) receptor. Eur J Pharmacol (2013) 0.92
Role of estrogen in angiogenesis in cardiovascular diseases. J Geriatr Cardiol (2013) 0.89
cAMP response element-binding protein (CREB) and nuclear factor κB mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes. J Biol Chem (2013) 0.88
G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth. Obstet Gynecol Int (2013) 0.88
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Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors. Arterioscler Thromb Vasc Biol (2014) 0.85
Emerging roles of GPER in diabetes and atherosclerosis. Trends Endocrinol Metab (2015) 0.84
G protein-coupled estrogen receptor-1 is involved in the protective effect of protocatechuic aldehyde against endothelial dysfunction. PLoS One (2014) 0.80
GPR30 regulates diet-induced adiposity in female mice and adipogenesis in vitro. Sci Rep (2016) 0.79
GPER-novel membrane oestrogen receptor. Clin Sci (Lond) (2016) 0.78
The effects of (-)-epicatechin on endothelial cells involve the G protein-coupled estrogen receptor (GPER). Pharmacol Res (2015) 0.78
Testosterone-derived estradiol production by male endothelium is robust and dependent on p450 aromatase via estrogen receptor alpha. Springerplus (2013) 0.77
Differences in GPR30 Regulation by Chlorotriazine Herbicides in Human Breast Cells. Biochem Res Int (2016) 0.77
Schizophrenia gene expression profile reverted to normal levels by antipsychotics. Int J Neuropsychopharmacol (2014) 0.76
G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity. J Endocrinol (2015) 0.76
Endothelial Cell Activation Is Regulated by Epidermal Growth Factor-like Domain 7 (Egfl7) during Inflammation. J Biol Chem (2016) 0.75
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Reprogramming of HUVECs into induced pluripotent stem cells (HiPSCs), generation and characterization of HiPSC-derived neurons and astrocytes. PLoS One (2015) 0.75
G-protein-coupled receptor 30 mediates the effects of estrogen on endothelial cell tube formation in vitro. Int J Mol Med (2017) 0.75
Sex Differences in Vascular Physiology and Pathophysiology: Estrogen and Androgen Signaling in Health and Disease. Am J Physiol Heart Circ Physiol (2017) 0.75
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Age moderates the short-term effects of transdermal 17beta-estradiol on endothelium-dependent vascular function in postmenopausal women. Arterioscler Thromb Vasc Biol (2007) 2.08
Ovariectomy augments hypertension in aging female Dahl salt-sensitive rats. Hypertension (2004) 2.05
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Estrogen causes dynamic alterations in endothelial estrogen receptor expression. Circ Res (2002) 1.74
Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta. Circulation (2001) 1.50
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Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology. Endocrinology (2012) 1.43
Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov (2006) 1.36
Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol (2009) 1.32
Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation. Int J Cardiol (2008) 1.31
Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts. Cancer Res (2010) 1.30
Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol (2010) 1.29
Estradiol and G1 reduce infarct size and improve immunosuppression after experimental stroke. J Immunol (2010) 1.25
Angiotensin II-induced MMP-2 release from endothelial cells is mediated by TNF-alpha. Am J Physiol Cell Physiol (2003) 1.23
Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration. Antioxid Redox Signal (2009) 1.17
17beta-estradiol downregulates tissue angiotensin-converting enzyme and ANG II type 1 receptor in female rats. Am J Physiol Regul Integr Comp Physiol (2004) 1.14
Influence of anti-TNF-alpha infliximab therapy on adhesion molecules associated with atherogenesis in patients with rheumatoid arthritis. Clin Exp Rheumatol (2006) 1.13
GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERα) phosphorylation signals. Endocrinology (2011) 1.11
Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury. Surgery (2010) 1.05
Sex steroids and vascular responses in hypertension and aging. Gend Med (2008) 1.04
Matrix metalloproteinase-2 is elevated in the plasma of women with preeclampsia. Hypertens Pregnancy (2001) 1.03
Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice. Mol Cell Endocrinol (2010) 1.02
The GPER1 agonist G-1 attenuates endothelial cell proliferation by inhibiting DNA synthesis and accumulating cells in the S and G2 phases of the cell cycle. J Vasc Res (2011) 1.02
Aged rats lose vasoprotective and anti-inflammatory actions of estrogen in injured arteries. Menopause (2007) 1.01
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Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30. Hypertension (2011) 0.97
Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30. Am J Physiol Cell Physiol (2009) 0.96
Position paper: The membrane estrogen receptor GPER--Clues and questions. Steroids (2012) 0.95
GPR30, but not estrogen receptor-alpha, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol. BMC Immunol (2010) 0.95
High glucose-induced oxidative stress alters estrogen effects on ERalpha and ERbeta in human endothelial cells: reversal by AMPK activator. J Steroid Biochem Mol Biol (2009) 0.93
The effects of preeclampsia and oxygen environment on endothelial release of matrix metalloproteinase-2. Hypertens Pregnancy (2004) 0.93
G protein-coupled oestrogen receptor 1 (GPER1)/GPR30: a new player in cardiovascular and metabolic oestrogenic signalling. Br J Pharmacol (2011) 0.92
Neuronal nitric oxide synthase regulates endothelial inflammation. J Leukoc Biol (2012) 0.91
Estrogens in vascular biology and disease: where do we stand today? Curr Opin Lipidol (2007) 0.90
Estrogen, inflammation and cardiovascular risk in women: a critical appraisal. Trends Endocrinol Metab (2004) 0.90
17beta-Estradiol induces protein S-nitrosylation in the endothelium. Cardiovasc Res (2009) 0.88
Modulation of endothelial cell expression of ICAM-1, E-selectin, and VCAM-1 by beta-estradiol, progesterone, and dexamethasone. Cell Immunol (1996) 0.88
Improvement of vascular function by acute and chronic treatment with the GPR30 agonist G1 in experimental diabetes mellitus. PLoS One (2012) 0.87
Suppression by 17beta-estradiol of monocyte adhesion to vascular endothelial cells is mediated by estrogen receptors. Life Sci (2004) 0.86
Differential effect of estrogen receptor alpha and beta agonists on the receptor for advanced glycation end product expression in human microvascular endothelial cells. Biochim Biophys Acta (2005) 0.84
Increased lectin-like oxidized low-density lipoprotein receptor-1 expression in the maternal vasculature of women with preeclampsia: role for peroxynitrite. Hypertension (2008) 0.84
Effects of testosterone and 17-beta-estradiol on TNF-alpha-induced E-selectin and VCAM-1 expression in endothelial cells. Analysis of the underlying receptor pathways. Life Sci (2002) 0.83
Estrogen decreases TNF-alpha and oxidized LDL induced apoptosis in endothelial cells. Steroids (2007) 0.83
Lack of oestrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination. Brain (2005) 0.82
Inhibition of TNF-alpha reduces transplant arteriosclerosis in a murine aortic transplant model. Transpl Int (2008) 0.82
Testosterone and estradiol modulate TNF-alpha-induced expression of adhesion molecules in endothelial cells. Methods Find Exp Clin Pharmacol (2002) 0.82
Role of estrogen receptor subtypes in estrogen-induced organ-specific vasorelaxation after trauma-hemorrhage. Am J Physiol Heart Circ Physiol (2008) 0.81
Estrogen receptor-{alpha} promotes endothelial cell motility through focal adhesion kinase. Mol Hum Reprod (2010) 0.80
High glucose blocks the effects of estradiol on human vascular cell growth: differential interaction with estradiol and raloxifene. J Steroid Biochem Mol Biol (2004) 0.79
17β-Estradiol induces vasorelaxation in a G-protein-coupled receptor 30-independent manner. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.79
Sex hormone regulation of systemic endothelial and renal microvascular reactivity in type-2 diabetes: studies in gonadectomized and sham-operated Zucker diabetic rats. Eur J Clin Invest (2004) 0.78
Estradiol modulates tumor necrosis factor-induced endothelial inflammation: role of tumor necrosis factor receptor 2. J Vasc Res (2012) 0.76
Chronic tumor necrosis factor-alpha inhibition enhances NO modulation of vascular function in estrogen-deficient rats. Hypertension (2005) 1.75
Estrogen improves cardiac recovery after ischemia/reperfusion by decreasing tumor necrosis factor-alpha. Cardiovasc Res (2006) 1.68
Tumor necrosis factor-alpha and vascular angiotensin II in estrogen-deficient rats. Hypertension (2006) 1.57
Prenatal hypoxia causes long-term alterations in vascular endothelin-1 function in aged male, but not female, offspring. Hypertension (2013) 1.53
Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring. FASEB J (2006) 1.37
Effects of hypoxia-induced intrauterine growth restriction on cardiopulmonary structure and function during adulthood. Cardiovasc Res (2008) 1.31
Differential effects of maternal hypoxia or nutrient restriction on carotid and femoral vascular function in neonatal rats. Am J Physiol Regul Integr Comp Physiol (2004) 1.23
Angiotensin II-induced MMP-2 release from endothelial cells is mediated by TNF-alpha. Am J Physiol Cell Physiol (2003) 1.23
Endothelial-dependent vasodilation is reduced in mesenteric arteries from superoxide dismutase knockout mice. Cardiovasc Res (2003) 1.20
Effects of maternal hypoxia or nutrient restriction during pregnancy on endothelial function in adult male rat offspring. J Physiol (2005) 1.20
Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model. Hypertension (2012) 1.12
Calorie restriction prevents hypertension and cardiac hypertrophy in the spontaneously hypertensive rat. Hypertension (2010) 1.11
Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome. Diabetes (2011) 1.11
TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol 3-kinase/Akt through the short form of cellular FLIP and Bcl-2. J Vasc Res (2005) 1.10
Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice. Biochim Biophys Acta (2013) 1.09
MMP-2 levels are elevated in the plasma of women who subsequently develop preeclampsia. Hypertens Pregnancy (2005) 1.08
Estrogen modulation of left ventricular remodeling in the aged heart. Cardiovasc Res (2003) 1.08
The early origins of cardiovascular health and disease: who, when, and how. Semin Reprod Med (2011) 1.07
Vascular adaptations to pregnancy in mice: effects on myogenic tone. Am J Physiol Heart Circ Physiol (2002) 1.04
The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives. Am J Physiol Regul Integr Comp Physiol (2011) 1.04
Preeclampsia: current understanding of the molecular basis of vascular dysfunction. Expert Rev Mol Med (2006) 1.03
Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. Am J Physiol Cell Physiol (2009) 1.03
Age-associated impairment in vasorelaxation to fluid shear stress in the female vasculature is improved by TNF-alpha antagonism. Am J Physiol Heart Circ Physiol (2005) 1.01
Long-term effects of intrauterine growth restriction on cardiac metabolism and susceptibility to ischaemia/reperfusion. Cardiovasc Res (2010) 1.00
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia. Cardiovasc Res (2010) 1.00
Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells. Am J Physiol Cell Physiol (2002) 1.00
Pregnancy-induced alterations of vascular function in mouse mesenteric and uterine arteries. Biol Reprod (2003) 0.98
Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted. Diabetes (2011) 0.98
TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension. Cardiovasc Res (2013) 0.97
Estrogen is a modulator of vascular inflammation. IUBMB Life (2008) 0.97
Estrogen reduces angiotensin II-induced nitric oxide synthase and NAD(P)H oxidase expression in endothelial cells. Arterioscler Thromb Vasc Biol (2003) 0.97
Bioactive natural constituents from food sources-potential use in hypertension prevention and treatment. Crit Rev Food Sci Nutr (2013) 0.95
The role of matrix metalloproteinases in vascular function: implications for normal pregnancy and pre-eclampsia. BJOG (2004) 0.95
Inhibition of trophoblast-induced spiral artery remodeling reduces placental perfusion in rat pregnancy. Hypertension (2010) 0.95
Gender differences in myogenic tone in superoxide dismutase knockout mouse: animal model of oxidative stress. Am J Physiol Heart Circ Physiol (2004) 0.94
Matrix metalloproteinase enhances big-endothelin-1 constriction in mesenteric vessels of pregnant rats with reduced uterine blood flow. Hypertension (2013) 0.94
ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. PLoS One (2012) 0.94
Vascular dysfunction in preeclampsia. Microcirculation (2014) 0.93
High glucose-induced oxidative stress alters estrogen effects on ERalpha and ERbeta in human endothelial cells: reversal by AMPK activator. J Steroid Biochem Mol Biol (2009) 0.93
The effects of preeclampsia and oxygen environment on endothelial release of matrix metalloproteinase-2. Hypertens Pregnancy (2004) 0.93
Cardioprotection by chronic estrogen or superoxide dismutase mimetic treatment in the aged female rat. Am J Physiol Heart Circ Physiol (2004) 0.93
Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction. Biol Reprod (2012) 0.93
Epigallocatechin-3-O-gallate inhibits TNFalpha-induced monocyte chemotactic protein-1 production from vascular endothelial cells. Life Sci (2008) 0.93
Regulation of vascular tone during pregnancy: a novel role for the pregnane X receptor. Hypertension (2006) 0.92
Neuronal nitric oxide synthase regulates endothelial inflammation. J Leukoc Biol (2012) 0.91
Mechanisms of endothelial dysfunction in resistance arteries from patients with end-stage renal disease. PLoS One (2012) 0.90
Role of neuronal nitric-oxide synthase in estrogen-induced relaxation in rat resistance arteries. J Pharmacol Exp Ther (2011) 0.89
17beta-Estradiol induces protein S-nitrosylation in the endothelium. Cardiovasc Res (2009) 0.88
Effects of resveratrol in pregnancy using murine models with reduced blood supply to the uterus. PLoS One (2013) 0.87
Structure and activity study of egg protein ovotransferrin derived peptides (IRW and IQW) on endothelial inflammatory response and oxidative stress. J Agric Food Chem (2013) 0.87
Endothelial colony-forming cells derived from pregnancies complicated by intrauterine growth restriction are fewer and have reduced vasculogenic capacity. J Clin Endocrinol Metab (2013) 0.87
Metabolites of progesterone and the pregnane X receptor: a novel pathway regulating uterine contractility in pregnancy? Am J Obstet Gynecol (2005) 0.87
The receptor for advanced glycation end products (RAGE) is elevated in women with preeclampsia. Hypertens Pregnancy (2003) 0.86
Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response. J Lipid Res (2005) 0.86
Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia. Hypertension (2012) 0.85
Effect of exercise on vascular superoxide dismutase expression in high-risk pregnancy. Am J Perinatol (2011) 0.85
Increased lectin-like oxidized low-density lipoprotein receptor-1 expression in the maternal vasculature of women with preeclampsia: role for peroxynitrite. Hypertension (2008) 0.84
Uterine artery function in a mouse model of pregnancy complicated by diabetes. Vascul Pharmacol (2008) 0.84
Myogenic reactivity is enhanced in rat radial uterine arteries in a model of maternal undernutrition. Am J Obstet Gynecol (2004) 0.84
Endothelin in the female vasculature: a role in aging? Am J Physiol Regul Integr Comp Physiol (2010) 0.83
Synergistic effects of prenatal hypoxia and postnatal high-fat diet in the development of cardiovascular pathology in young rats. Am J Physiol Regul Integr Comp Physiol (2012) 0.83
Restraint stress up-regulates lectin-like oxidized low-density lipoprotein receptor-1 in aorta of apolipoprotein E-deficient mice. Stress (2010) 0.83
Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone. Biol Reprod (2005) 0.83
Uterine vasculature remodeling in human pregnancy involves functional macrochimerism by endothelial colony forming cells of fetal origin. Stem Cells (2013) 0.83
Egg-derived tri-peptide IRW exerts antihypertensive effects in spontaneously hypertensive rats. PLoS One (2013) 0.83
Effect of gestational diabetes on maternal artery function. Reprod Sci (2011) 0.82
Vascular aging and hemodynamic stability in the intraoperative period. Front Physiol (2012) 0.82
Egg-derived peptide IRW inhibits TNF-α-induced inflammatory response and oxidative stress in endothelial cells. J Agric Food Chem (2010) 0.82
Induction of matrix metalloproteinase-2 enhances systemic arterial contraction after hypoxia. Am J Physiol Heart Circ Physiol (2006) 0.82
Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets. Am J Physiol Heart Circ Physiol (2009) 0.81
Propofol increases vascular relaxation in aging rats chronically treated with the angiotensin-converting enzyme inhibitor captopril. Anesth Analg (2013) 0.81
Estrogen replacement increases matrix metalloproteinase contribution to vasoconstriction in a rat model of menopause. J Hypertens (2009) 0.81
Increased myogenic responses in uterine but not mesenteric arteries from pregnant offspring of diet-restricted rat dams. Biol Reprod (2004) 0.81
Inhibition of lectin-like oxidized low-density lipoprotein-1 receptor protects against plasma-mediated vascular dysfunction associated with pre-eclampsia. Am J Hypertens (2012) 0.81
Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase. Hypertension (2009) 0.80
Fibrocyte-like cells from intrauterine growth restriction placentas have a reduced ability to stimulate angiogenesis. Am J Pathol (2013) 0.80
Previous gestational diabetes impairs long-term endothelial function in a mouse model of complicated pregnancy. Am J Physiol Regul Integr Comp Physiol (2010) 0.79
Ovariectomy in aged versus young rats augments matrix metalloproteinase-mediated vasoconstriction in mesenteric arteries. Menopause (2010) 0.79
Estradiol attenuates high glucose-induced endothelial nitrotyrosine: role for neuronal nitric oxide synthase. Am J Physiol Cell Physiol (2011) 0.79
The effects of propofol on vascular function in mesenteric arteries of the aging rat. Am J Physiol Heart Circ Physiol (2009) 0.79
Ovariectomy, but not estrogen deficiency, increases CYP4A modulation of alpha(1)-adrenergic vasoconstriction in aging female rats. Am J Hypertens (2008) 0.78
Arterial endothelium-derived hyperpolarization: potential role in pregnancy adaptations and complications. J Cardiovasc Pharmacol (2013) 0.78
Pleiotropic actions of forskolin result in phosphatidylserine exposure in primary trophoblasts. PLoS One (2013) 0.78
The maternal environment programs postnatal weight gain and glucose tolerance of male offspring, but placental and fetal growth are determined by fetal genotype in the Leprdb/+ model of gestational diabetes. Endocrinology (2015) 0.78
Estrogen replacement reduces PGHS-2-dependent vasoconstriction in the aged rat. Am J Physiol Heart Circ Physiol (2002) 0.78
Administration of the PARP inhibitor Pj34 ameliorates the impaired vascular function associated with eNOS(-/-) mice. Reprod Sci (2012) 0.78
Oxygen and perinatal origins of adulthood diseases: is oxidative stress the unifying element? Hypertension (2008) 0.78
Airway smooth muscle changes in the nitrofen-induced congenital diaphragmatic hernia rat model. Pediatr Res (2003) 0.77
Proteasome inhibition decreases inflammation in human endothelial cells exposed to lipopolysaccharide. J Cardiovasc Pharmacol (2012) 0.77
Aging increases cytochrome P450 4A modulation of alpha1-adrenergic vasoconstriction in mesenteric arteries. J Cardiovasc Pharmacol (2008) 0.77
The neuroprotective effects of estrogen in SK-N-SH neuroblastoma cell cultures. Neurochem Int (2004) 0.77
Altered neuronal nitric oxide synthase in the aging vascular system: implications for estrogens therapy. Endocrinology (2012) 0.77
Vascular effects of aerobic exercise training in rat adult offspring exposed to hypoxia-induced intrauterine growth restriction. J Physiol (2015) 0.77
Maternal stress and development of atherosclerosis in the adult apolipoprotein E-deficient mouse offspring. Am J Physiol Regul Integr Comp Physiol (2009) 0.77
Effect of peroxynitrite scavenging on endothelial cells stimulated by plasma from women with preeclampsia: a proteomic approach. Hypertens Pregnancy (2010) 0.76
Enhanced trimethylation of histone h3 mediates impaired expression of hepatic glucose 6-phosphatase expression in offspring from rat dams exposed to hypoxia during pregnancy. Reprod Sci (2013) 0.76
Estradiol modulates tumor necrosis factor-induced endothelial inflammation: role of tumor necrosis factor receptor 2. J Vasc Res (2012) 0.76
Influence of constriction, wall tension, smooth muscle activation and cellular deformation on rat resistance artery vasodilator reactivity. Cell Physiol Biochem (2012) 0.76
Maternal nutrient restriction reduces carotid artery constriction without increasing nitric oxide synthesis in the late gestation rat fetus. Pediatr Res (2005) 0.75
Prenatal hypoxia is associated with long-term retinal dysfunction in rats. PLoS One (2013) 0.75