Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice.

PubWeight™: 0.84‹?›

🔗 View Article (PMC 4387281)

Published in J Exp Med on March 16, 2015

Authors

Liang Gao1, David Brenner1, Enric Llorens-Bobadilla1, Gonzalo Saiz-Castro1, Tobias Frank2, Peter Wieghofer3, Oliver Hill4, Meinolf Thiemann4, Saoussen Karray5, Marco Prinz3, Jochen H Weishaupt6, Ana Martin-Villalba7

Author Affiliations

1: Division of Molecular Neurobiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
2: Department of Neurology, University Medical Center, Georg-August-University, 37075 Göttingen, Germany.
3: Institute of Neuropathology, Faculty of Biology, and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79098 Freiburg, Germany Institute of Neuropathology, Faculty of Biology, and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79098 Freiburg, Germany.
4: Apogenix GmbH, 69120 Heidelberg, Germany.
5: Institut National de la Santé et de la Recherche Médicale (INSERM), U1160, Université Paris Diderot, 75010 Paris, France.
6: Department of Neurology, University of Ulm, 89081 Ulm, Germany.
7: Division of Molecular Neurobiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany a.martin-villalba@dkfz.de.

Articles cited by this

Parkinson's disease: mechanisms and models. Neuron (2003) 14.84

Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science (2010) 12.15

A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science (2012) 8.42

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci (2007) 6.23

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity (2012) 6.18

Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity (2010) 5.43

The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci (2006) 4.93

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med (1999) 4.88

Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci (2002) 4.38

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci (2011) 4.21

Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol (2011) 3.95

Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci (2013) 3.94

The myeloid cells of the central nervous system parenchyma. Nature (2010) 3.80

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat Med (2001) 3.32

The CD95 receptor: apoptosis revisited. Cell (2007) 3.13

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci (2013) 3.11

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest (2008) 2.91

Use of ibuprofen and risk of Parkinson disease. Neurology (2011) 2.70

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest (2012) 2.67

Fas engagement induces neurite growth through ERK activation and p35 upregulation. Nat Cell Biol (2003) 2.64

Glial reactions in Parkinson's disease. Mov Disord (2008) 2.62

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain (2009) 2.59

Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease. J Neurosci (2011) 2.31

Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell (2008) 2.21

The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell (2009) 2.11

A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. J Exp Med (1984) 2.06

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat Neurosci (2013) 2.03

Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury. Nat Med (2004) 1.95

Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology. Brain (2008) 1.92

CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site. Immunity (2010) 1.91

Microglia in the CNS: immigrants from another world. Glia (2011) 1.90

Monocytes: subsets, origins, fates and functions. Curr Opin Hematol (2010) 1.77

Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain (2008) 1.65

Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc Natl Acad Sci U S A (1996) 1.40

Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand. J Neurosci (2005) 1.32

Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson's disease mice model. Neurodegeneration (1996) 1.30

Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele. J Immunol (2004) 1.24

Control of neuronal branching by the death receptor CD95 (Fas/Apo-1). Cell Death Differ (2006) 1.19

Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. J Neurosci (2004) 1.13

Bone marrow-derived microglia contribute to the neuroinflammatory response and express iNOS in the MPTP mouse model of Parkinson's disease. Neurobiol Dis (2005) 1.12

Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias. PLoS One (2013) 1.12

Association between Parkinson's disease and the HLA-DRB1 locus. Mov Disord (2012) 1.09

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism. Proc Natl Acad Sci U S A (2011) 1.07

Programmed cell death in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.04

Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson's disease. Neurobiol Dis (2007) 1.01

Blood-brain barrier permeability after gamma whole-body irradiation: an in vivo microdialysis study. Can J Physiol Pharmacol (2002) 1.00

Inflammatory dysregulation of blood monocytes in Parkinson's disease patients. Acta Neuropathol (2014) 1.00

Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease. J Exp Med (2005) 0.93

CD95 in cancer: tool or target? Trends Mol Med (2013) 0.92

Peripheral LPS administrations up-regulate Fas and FasL on brain microglial cells: a brain protective or pathogenic event? J Neuroimmunol (2002) 0.91

Fas and Fas-L expression in Huntington's disease and Parkinson's disease. Neuropathol Appl Neurobiol (2000) 0.91

The soluble form of Fas molecule is elevated in parkinsonian brain tissues. Neurosci Lett (1996) 0.90

Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease. Mov Disord (2013) 0.89

Optimal protocol for total body irradiation for allogeneic bone marrow transplantation in mice. Bone Marrow Transplant (2002) 0.89

Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson's disease. Brain (2012) 0.88