Published in Nucleic Acids Res on March 30, 2015
Animal Mitochondrial DNA Replication. Enzymes (2016) 0.84
Human mitochondrial DNA replication machinery and disease. Curr Opin Genet Dev (2016) 0.82
Structural Mechanisms of Hexameric Helicase Loading, Assembly, and Unwinding. F1000Res (2016) 0.78
Structure, function and evolution of the animal mitochondrial replicative DNA helicase. Crit Rev Biochem Mol Biol (2015) 0.77
Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE. Nucleic Acids Res (2016) 0.76
Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING. J Biol Chem (2016) 0.75
Novel neuro-audiological findings and further evidence for TWNK involvement in Perrault syndrome. J Transl Med (2017) 0.75
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89
Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations. J Comput Chem (2004) 17.97
Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy. J Mol Biol (2003) 12.04
Very fast empirical prediction and rationalization of protein pKa values. Proteins (2005) 8.61
Structure and mechanism of helicases and nucleic acid translocases. Annu Rev Biochem (2007) 7.83
New developments in the ATSAS program package for small-angle scattering data analysis. J Appl Crystallogr (2012) 7.04
Structural characterization of flexible proteins using small-angle X-ray scattering. J Am Chem Soc (2007) 6.53
Flexible fitting of atomic structures into electron microscopy maps using molecular dynamics. Structure (2008) 5.97
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat Genet (2001) 5.09
Thermofluor-based high-throughput stability optimization of proteins for structural studies. Anal Biochem (2006) 5.05
Mechanism of DNA translocation in a replicative hexameric helicase. Nature (2006) 4.91
Image processing for electron microscopy single-particle analysis using XMIPP. Nat Protoc (2008) 4.90
Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides. Cell (2000) 4.27
Scalable web services for the PSIPRED Protein Analysis Workbench. Nucleic Acids Res (2013) 4.24
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. Nature (2009) 2.83
Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins. Nucleic Acids Res (1998) 2.82
GraFix: sample preparation for single-particle electron cryomicroscopy. Nat Methods (2007) 2.71
Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7. Cell (1999) 2.54
Reconstitution of a minimal mtDNA replisome in vitro. EMBO J (2004) 2.49
Structure of the RNA polymerase domain of E. coli primase. Science (2000) 2.41
The bacterial replicative helicase DnaB evolved from a RecA duplication. Genome Res (2000) 2.39
The hexameric helicase DnaB adopts a nonplanar conformation during translocation. Cell (2012) 2.37
TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein. J Biol Chem (2003) 2.24
Organization and evolution of bacterial and bacteriophage primase-helicase systems. J Mol Evol (1992) 2.19
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number. Hum Mol Genet (2004) 2.00
The crystal structure of the bifunctional primase-helicase of bacteriophage T7. Mol Cell (2003) 1.99
Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes. Nucleic Acids Res (2007) 1.69
Effect of interdomain dynamics on the structure determination of modular proteins by small-angle scattering. Eur Biophys J (2009) 1.62
Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis. Mol Cell (2003) 1.61
Mechanism and evolution of DNA primases. Biochim Biophys Acta (2009) 1.60
Crosstalk between primase subunits can act to regulate primer synthesis in trans. Mol Cell (2005) 1.57
CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation. Proc Natl Acad Sci U S A (2010) 1.49
Identification of a DNA primase template tracking site redefines the geometry of primer synthesis. Nat Struct Mol Biol (2008) 1.42
Infantile onset spinocerebellar ataxia is caused by recessive mutations in mitochondrial proteins Twinkle and Twinky. Hum Mol Genet (2005) 1.38
A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerases. J Mol Biol (2000) 1.30
A ring-opening mechanism for DNA binding in the central channel of the T7 helicase-primase protein. EMBO J (2000) 1.29
Twinkle, the mitochondrial replicative DNA helicase, is widespread in the eukaryotic radiation and may also be the mitochondrial DNA primase in most eukaryotes. J Mol Evol (2006) 1.28
SPIRE: the SPIDER reconstruction engine. J Struct Biol (2006) 1.28
Modular architecture of the hexameric human mitochondrial DNA helicase. J Mol Biol (2007) 1.21
Structure of the zinc-binding domain of Bacillus stearothermophilus DNA primase. Structure (2000) 1.21
3-D structures of macromolecules using single-particle analysis in EMAN. Methods Mol Biol (2010) 1.18
Parallel Generalized Born Implicit Solvent Calculations with NAMD. J Chem Theory Comput (2011) 1.17
Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7. Proc Natl Acad Sci U S A (2002) 1.10
The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities. Nucleic Acids Res (2007) 1.10
Recessive twinkle mutations cause severe epileptic encephalopathy. Brain (2009) 1.04
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity. J Biol Chem (2010) 1.00
Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase. J Biol Chem (2012) 0.99
The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis. Nucleic Acids Res (2011) 0.94
Dynamic effects of cofactors and DNA on the oligomeric state of human mitochondrial DNA helicase. J Biol Chem (2010) 0.93
An in trans interaction at the interface of the helicase and primase domains of the hexameric gene 4 protein of bacteriophage T7 modulates their activities. J Biol Chem (2009) 0.88
Loading strategies of ring-shaped nucleic acid translocases and helicases. Curr Opin Struct Biol (2013) 0.84
Syndromes associated with mitochondrial DNA depletion. Ital J Pediatr (2014) 0.82