Published in Mol Cell on November 11, 2005
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Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Nucleic Acids Res (2014) 1.13
DNA mechanics as a tool to probe helicase and translocase activity. Nucleic Acids Res (2006) 1.13
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Inhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region. Nucleic Acids Res (2008) 1.05
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Structures of human primase reveal design of nucleotide elongation site and mode of Pol α tethering. Proc Natl Acad Sci U S A (2013) 1.01
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The strictly conserved Arg-321 residue in the active site of Escherichia coli topoisomerase I plays a critical role in DNA rejoining. J Biol Chem (2011) 0.87
Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome. J Biol Chem (2016) 0.86
Biochemical and EPR-spectroscopic investigation into heterologously expressed vinyl chloride reductive dehalogenase (VcrA) from Dehalococcoides mccartyi strain VS. J Am Chem Soc (2015) 0.84
Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis. Nucleic Acids Res (2013) 0.83
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Structure of the PolIIIα-τc-DNA complex suggests an atomic model of the replisome. Structure (2013) 0.83
Hyperthermophilic Aquifex aeolicus initiates primer synthesis on a limited set of trinucleotides comprised of cytosines and guanines. Nucleic Acids Res (2008) 0.83
The primase domain of PfPrex is a proteolytically matured, essential enzyme of the apicoplast. Mol Biochem Parasitol (2011) 0.82
Domain swapping reveals that the C- and N-terminal domains of DnaG and DnaB, respectively, are functional homologues. Mol Microbiol (2007) 0.82
The hexameric structure of the human mitochondrial replicative helicase Twinkle. Nucleic Acids Res (2015) 0.82
Class-specific restrictions define primase interactions with DNA template and replicative helicase. Nucleic Acids Res (2010) 0.81
Replication-fork dynamics. Cold Spring Harb Perspect Biol (2014) 0.81
Zinc-binding domain of the bacteriophage T7 DNA primase modulates binding to the DNA template. J Biol Chem (2012) 0.78
Insight into the Human DNA Primase Interaction with Template-Primer. J Biol Chem (2015) 0.78
Allosteric regulation of the primase (DnaG) activity by the clamp-loader (tau) in vitro. Mol Microbiol (2009) 0.77
Structure, function and evolution of the animal mitochondrial replicative DNA helicase. Crit Rev Biochem Mol Biol (2015) 0.77
Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile. Open Biol (2016) 0.76
Overexpression, crystallization and preliminary X-ray crystallographic analysis of the RNA polymerase domain of primase from Streptococcus mutans strain UA159. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75
Control of Initiation of DNA Replication in Bacillus subtilis and Escherichia coli. Genes (Basel) (2017) 0.75
Identification of DNA primase inhibitors via a combined fragment-based and virtual screening. Sci Rep (2016) 0.75
The application of thermophilic DNA primase TtDnaG2 to DNA amplification. Sci Rep (2017) 0.75
Independent and Stochastic Action of DNA Polymerases in the Replisome. Cell (2017) 0.75
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution. Q Rev Biophys (2007) 9.07
Development of an improved four-site water model for biomolecular simulations: TIP4P-Ew. J Chem Phys (2004) 6.09
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83
Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct (2006) 4.74
A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proc Natl Acad Sci U S A (2002) 4.16
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology. Q Rev Biophys (2008) 3.50
Running in reverse: the structural basis for translocation polarity in hexameric helicases. Cell (2009) 3.38
Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annu Rev Biophys Biomol Struct (2004) 3.37
Structure and flexibility within proteins as identified through small angle X-ray scattering. Gen Physiol Biophys (2009) 3.24
Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading. Cell (2003) 3.00
DNA replication initiation: mechanisms and regulation in bacteria. Nat Rev Microbiol (2007) 2.96
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93
Structural basis for gate-DNA recognition and bending by type IIA topoisomerases. Nature (2007) 2.79
Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling. Nat Struct Mol Biol (2006) 2.73
The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol (2009) 2.69
All tangled up: how cells direct, manage and exploit topoisomerase function. Nat Rev Mol Cell Biol (2011) 2.66
Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export. Nat Cell Biol (2006) 2.58
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat Struct Mol Biol (2004) 2.25
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell (2006) 2.23
Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex. Science (2007) 2.10
The structural basis for substrate specificity in DNA topoisomerase IV. J Mol Biol (2005) 2.08
Structure and function of the conserved core of histone deposition protein Asf1. Curr Biol (2003) 2.02
The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation. EMBO J (2002) 1.98
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep (2013) 1.96
The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc Natl Acad Sci U S A (2004) 1.93
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem (2009) 1.91
The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes Dev (2004) 1.90
The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. J Mol Biol (2012) 1.87
Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol (2006) 1.80
The structure and conformation of Lys63-linked tetraubiquitin. J Mol Biol (2009) 1.77
Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation. Mol Cell Biol (2002) 1.77
Suite of three protein crystallography beamlines with single superconducting bend magnet as the source. J Synchrotron Radiat (2004) 1.70
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export. Nature (2011) 1.70
Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source. J Appl Crystallogr (2013) 1.69
Identification of oligonucleotide sequences that direct the movement of the Escherichia coli FtsK translocase. Proc Natl Acad Sci U S A (2005) 1.66
A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination. J Am Chem Soc (2006) 1.65
Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. Nat Struct Mol Biol (2006) 1.64
Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases. Structure (2012) 1.64
The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore. Mol Cell (2004) 1.59
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature (2010) 1.59
Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor. Cell (2006) 1.58
DNA stretching by bacterial initiators promotes replication origin opening. Nature (2011) 1.55
Structural synergy and molecular crosstalk between bacterial helicase loaders and replication initiators. Cell (2008) 1.51
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A (2003) 1.44
The nuts and bolts of ring-translocase structure and mechanism. Curr Opin Struct Biol (2011) 1.44
Identification of a DNA primase template tracking site redefines the geometry of primer synthesis. Nat Struct Mol Biol (2008) 1.42
Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction. Proc Natl Acad Sci U S A (2010) 1.41
Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control. Genes Dev (2012) 1.37
Function and structure of a prokaryotic formylglycine-generating enzyme. J Biol Chem (2008) 1.35
Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics. BMC Struct Biol (2006) 1.34
Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis. J Mol Biol (2008) 1.32
Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D. J Biol Chem (2006) 1.31
Comprehensive macromolecular conformations mapped by quantitative SAXS analyses. Nat Methods (2013) 1.29
AAA+ ATPases in the initiation of DNA replication. Crit Rev Biochem Mol Biol (2008) 1.29
Mechanisms for initiating cellular DNA replication. Annu Rev Biochem (2013) 1.28
THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. Nat Struct Mol Biol (2009) 1.27
The MukF subunit of Escherichia coli condensin: architecture and functional relationship to kleisins. EMBO J (2005) 1.24
High-throughput SAXS for the characterization of biomolecules in solution: a practical approach. Methods Mol Biol (2014) 1.22
Barrier-to-autointegration factor (BAF) condenses DNA by looping. Proc Natl Acad Sci U S A (2009) 1.22
ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote. Proc Natl Acad Sci U S A (2012) 1.21
Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography. J Struct Biol (2006) 1.21
Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops. Proc Natl Acad Sci U S A (2011) 1.21
Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution. EMBO J (2003) 1.18
Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface. J Biol Chem (2006) 1.16
Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum. Proc Natl Acad Sci U S A (2010) 1.16
The bacterial DnaC helicase loader is a DnaB ring breaker. Cell (2013) 1.14
Small-angle scattering and the structure of ambient liquid water. Proc Natl Acad Sci U S A (2010) 1.13
Regulation of bacterial priming and daughter strand synthesis through helicase-primase interactions. Nucleic Acids Res (2006) 1.13
Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci (2007) 1.11
Origin remodeling and opening in bacteria rely on distinct assembly states of the DnaA initiator. J Biol Chem (2010) 1.10
A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function. Nucleic Acids Res (2010) 1.09
Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat Struct Mol Biol (2012) 1.09
Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding. J Biol Chem (2014) 1.08
Biochemical characterization of Cdc6/Orc1 binding to the replication origin of the euryarchaeon Methanothermobacter thermoautotrophicus. Nucleic Acids Res (2004) 1.08
Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Mol Cell (2006) 1.07
Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases. Mol Microbiol (2008) 1.07
The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks. Nucleic Acids Res (2011) 1.07
A structural framework for replication origin opening by AAA+ initiation factors. Curr Opin Struct Biol (2012) 1.06
Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI. Structure (2005) 1.06
Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J Mol Biol (2008) 1.05
Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Proc Natl Acad Sci U S A (2009) 1.05
Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. J Mol Biol (2008) 1.03
Software for the high-throughput collection of SAXS data using an enhanced Blu-Ice/DCS control system. J Synchrotron Radiat (2010) 1.03
Crystal structure of the DNA gyrase GyrA N-terminal domain from Mycobacterium tuberculosis. Proteins (2010) 1.03
Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI. Nat Struct Mol Biol (2007) 1.02
Mechanisms for defining supercoiling set point of DNA gyrase orthologs: II. The shape of the GyrA subunit C-terminal domain (CTD) is not a sole determinant for controlling supercoiling efficiency. J Biol Chem (2012) 1.01
Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72. Structure (2009) 1.00
Contributions of folding cores to the thermostabilities of two ribonucleases H. Protein Sci (2002) 0.99
How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases. J Mol Biol (2008) 0.98
Molecular determinants of origin discrimination by Orc1 initiators in archaea. Nucleic Acids Res (2011) 0.98
The role of DNA bending in type IIA topoisomerase function. Nucleic Acids Res (2013) 0.98
Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin. Structure (2005) 0.97
ATP binding controls distinct structural transitions of Escherichia coli DNA gyrase in complex with DNA. Nat Struct Mol Biol (2012) 0.97
Mechanisms for defining supercoiling set point of DNA gyrase orthologs: I. A nonconserved acidic C-terminal tail modulates Escherichia coli gyrase activity. J Biol Chem (2012) 0.97
A naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogs. Proc Natl Acad Sci U S A (2010) 0.97
The crystal structure of the hinge domain of the Escherichia coli structural maintenance of chromosomes protein MukB. J Mol Biol (2009) 0.97
Macro-to-micro structural proteomics: native source proteins for high-throughput crystallization. PLoS One (2012) 0.96
Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein. Biochemistry (2009) 0.96
Crystal structure of the unliganded retinoblastoma protein pocket domain. Proteins (2011) 0.94
SnapShot: nucleic acid helicases and translocases. Cell (2008) 0.92