Published in J Biol Inorg Chem on February 10, 2015
Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63
Interleukin-17 family members and inflammation. Immunity (2004) 16.16
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 12.68
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity (1996) 8.16
Plasticity of CD4+ T cell lineage differentiation. Immunity (2009) 8.08
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol (2007) 4.29
Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat Rev Immunol (2011) 4.29
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 3.52
Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol (2004) 3.51
Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology (2010) 3.51
Anti-inflammatory Agents: Present and Future. Cell (2010) 3.13
Regulation of the T cell response. Clin Exp Allergy (2006) 2.16
Interferon-gamma: a historical perspective. Cytokine Growth Factor Rev (2009) 2.03
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol (2007) 1.87
Th17 cells: from precursors to players in inflammation and infection. Int Immunol (2009) 1.77
An overview of the immune system. Lancet (2001) 1.73
Reprogramming the signalling requirement for AP-1 (activator protein-1) activation during differentiation of precursor CD4+ T-cells into effector Th1 and Th2 cells. Genes Funct (1997) 1.52
Complexes of metals other than platinum as antitumour agents. Eur J Clin Pharmacol (1994) 1.29
Ruthenium-based chemotherapeutics: are they ready for prime time? Cancer Chemother Pharmacol (2010) 1.29
DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity. Drug Resist Updat (2006) 1.25
Highly active neutral ruthenium(II) arene complexes: synthesis, characterization, and investigation of their anticancer properties. J Inorg Biochem (2012) 1.10
Helper T-cell identity and evolution of differential transcriptomes and epigenomes. Immunol Rev (2013) 1.05
Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3. J Exp Med (2014) 1.03
The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells. Cancer Lett (2005) 1.01
Cellular and population plasticity of helper CD4(+) T cell responses. Front Physiol (2013) 0.96
Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis. Immunol Cell Biol (2011) 0.93
Competitive reactions of a ruthenium arene anticancer complex with histidine, cytochrome c and an oligonucleotide. J Biol Inorg Chem (2005) 0.92
A complex issue on CD4(+) T-cell subsets. Immunol Rev (2013) 0.90
Drug control of solid tumour metastases: a critical view. Anticancer Res (1999) 0.88
Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds. Inorg Chem (2012) 0.85
Metal-drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells. J Biol Inorg Chem (2013) 0.85
Synergistic antitumor interactions between newly synthesized ruthenium complexes and cytokines in human colon carcinoma cell lines. Semin Oncol (1992) 0.85
Down-regulation of tumour gelatinase/inhibitor balance and preservation of tumour endothelium by an anti-metastatic ruthenium complex. Int J Cancer (1996) 0.84
Ruthenium(II) arene complexes with chelating chloroquine analogue ligands: synthesis, characterization and in vitro antimalarial activity. Dalton Trans (2012) 0.84
Chlorido-containing ruthenium(II) and iridium(III) complexes as antimicrobial agents. Dalton Trans (2013) 0.78
Intratumoral NAMI-A treatment triggers metastasis reduction, which correlates to CD44 regulation and tumor infiltrating lymphocyte recruitment. J Pharmacol Exp Ther (2004) 0.77
Synthesis, characterization, DNA interaction, antioxidant and anticancer activity of new ruthenium(II) complexes of thiosemicarbazone/semicarbazone bearing 9,10-phenanthrenequinone. J Photochem Photobiol B (2013) 0.77
The ruthenium complex cis-(Dichloro)Tetraammineruthenium(III) chloride presents immune stimulatory activity on human peripheral blood mononuclear cells. Biol Trace Elem Res (2009) 0.77
Cocultures of metastatic and host immune cells: selective effects of NAMI-A for tumor cells. Cancer Immunol Immunother (2004) 0.77
Ruthenium Red potently inhibits immune responses both in vitro and in vivo. Int J Immunopharmacol (1995) 0.77
In vitro immunomodulatory activity of ruthenium complexes. Inflamm Res (2003) 0.76
Cationic arene ruthenium(II) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents. Dalton Trans (2013) 0.76
Synthesis and immunosuppressive activity of ruthenium complexes. Bioorg Med Chem Lett (1998) 0.76
Synthesis, characterization, DNA interaction, antioxidant and anticancer activity studies of ruthenium(II) polypyridyl complexes. J Photochem Photobiol B (2013) 0.76
In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells. Cell Cycle (2011) 1.46
Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Endocrinology (2005) 1.36
Highly active neutral ruthenium(II) arene complexes: synthesis, characterization, and investigation of their anticancer properties. J Inorg Biochem (2012) 1.10
Resistance to TRAIL and how to surmount it. Immunol Res (2012) 1.08
Protonated nucleobase ligands: synthesis, structure and characterization of 9-methyladeninium hexachloroplatinate and pentachloro(9-methyladeninium)platinum(IV). J Inorg Biochem (2004) 1.02
Synthesis, characterization, and structure of [[PtMe(3)(9-MeA)](3)] (9-MeAH = 9-Methyladenine): a cyclic trimeric platinum(IV) complex with a nucleobase. Inorg Chem (2002) 1.00
Astrocyte-induced regulatory T cells mitigate CNS autoimmunity. Glia (2004) 1.00
Neutralization of macrophage migration inhibitory factor-novel approach for the treatment of immunoinflammatory disorders. Int Immunopharmacol (2006) 0.97
Astrocytes stimulate interleukin-17 and interferon-gamma production in vitro. J Neurosci Res (2007) 0.96
Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis. Immunol Cell Biol (2011) 0.93
Synthesis and in vitro antitumoral activity of novel O,O'-di-2-alkyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate ligands and corresponding platinum(II/IV) complexes. J Inorg Biochem (2007) 0.91
Beta cell function: the role of macrophage migration inhibitory factor. Immunol Res (2012) 0.88
Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cells. Invest New Drugs (2009) 0.87
Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo. Mol Cancer Ther (2008) 0.87
Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. Food Chem (2012) 0.86
In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immunol (2007) 0.86
Quantitative site-specific analysis of protein glycosylation by LC-MS using different glycopeptide-enrichment strategies. Anal Biochem (2009) 0.86
Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions. Radiat Oncol (2011) 0.85
Carbaboranes as pharmacophores: similarities and differences between aspirin and asborin. Eur J Med Chem (2011) 0.84
Strain difference in susceptibility to experimental autoimmune encephalomyelitis between Albino Oxford and Dark Agouti rats correlates with disparity in production of IL-17, but not nitric oxide. J Neurosci Res (2006) 0.83
Natural and newly synthesized hydroxy-1-aryl-isochromans: a class of potential antioxidants and radical scavengers. Free Radic Res (2005) 0.82
Pharmacological application of carbon monoxide ameliorates islet-directed autoimmunity in mice via anti-inflammatory and anti-apoptotic effects. Diabetologia (2014) 0.82
On the discovery, biological effects, and use of Cisplatin and metallocenes in anticancer chemotherapy. Bioinorg Chem Appl (2012) 0.81
Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro. J Cell Physiol (2013) 0.81
Ribavirin reduces clinical signs and pathological changes of experimental autoimmune encephalomyelitis in Dark Agouti rats. J Neurosci Res (2003) 0.81
Betulinic acid regulates generation of neuroinflammatory mediators responsible for tissue destruction in multiple sclerosis in vitro. Acta Pharmacol Sin (2013) 0.80
Cytotoxic and immune-sensitizing properties of nitric oxide-modified Saquinavir in iNOS-positive human melanoma cells. J Cell Physiol (2011) 0.79
Apotransferrin inhibits interleukin-2 expression and protects mice from experimental autoimmune encephalomyelitis. J Neuroimmunol (2013) 0.78
Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production. Int Immunopharmacol (2008) 0.78
The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt. Mol Cancer Ther (2009) 0.78
A role for macrophage migration inhibitory factor in protective immunity against Aspergillus fumigatus. Immunobiology (2011) 0.78
The synthesis, spectroscopic, X-ray characterization and in vitro cytotoxic testing results of activity of five new trans-platinum(IV) complexes with functionalized pyridines. Eur J Med Chem (2012) 0.78
Novel methylene modified cyclohexyl ethylenediamine-N,N'-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. J Inorg Biochem (2012) 0.78
Synthesis, characterization, in vitro antitumoral investigations and interaction with plasmid pBR322 DNA of R2eddp-platinum(IV) complexes (R = Et, n-Pr). Dalton Trans (2009) 0.77
Unique antineoplastic profile of Saquinavir-NO, a novel NO-derivative of the protease inhibitor Saquinavir, on the in vitro and in vivo tumor formation of A375 human melanoma cells. Oncol Rep (2012) 0.77
Stereospecific ligands and their complexes. Part VII. Synthesis, characterization and in vitro antitumoral activity of platinum(II) complexes with O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid. Eur J Med Chem (2011) 0.77
Platinum(II/IV) complexes containing ethylenediamine-N,N'-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. Metallomics (2012) 0.77
Anticancer potential of (pentamethylcyclopentadienyl)chloridoiridium(III) complexes bearing κP and κP,κS-coordinated Ph2 PCH2 CH2 CH2 S(O)x Ph (x=0-2) ligands. ChemMedChem (2014) 0.77
Solid-phase synthesis of reduced selenocysteine tetrapeptides and their oxidized analogs containing selenenylsulfide eight-membered rings. Mol Divers (2013) 0.77
Cytotoxicity, apoptosis and study of the DNA-binding properties of bi- and tetranuclear gallium(III) complexes with heterocyclic thiolato ligands. Invest New Drugs (2010) 0.77
The role of endogenous glucocorticoids in glucose metabolism and immune status of MIF-deficient mice. Eur J Pharmacol (2013) 0.77
Differential strain-related tissue immune response to sublethal systemic Aspergillus fumigatus infection in mice. APMIS (2012) 0.77
Cationic arene ruthenium(II) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents. Dalton Trans (2013) 0.76
Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: clinical and histopathological evaluation. J Neurol Sci (2007) 0.76
Therapeutic potential of nitric oxide-modified drugs in colon cancer cells. Mol Pharmacol (2012) 0.76
Macrophage migration inhibitory factor (MIF) enhances palmitic acid- and glucose-induced murine beta cell dysfunction and destruction in vitro. Growth Factors (2012) 0.76
Study of the anticancer properties of tin(IV) carboxylate complexes on a panel of human tumor cell lines. ChemMedChem (2011) 0.76
Organogallium(III) complexes as apoptosis promoting anticancer agents for head and neck squamous cell carcinoma (HNSCC) cell lines. J Inorg Biochem (2010) 0.76
Differential mechanisms of resistance to sublethal systemic Aspergillus fumigatus infection in immunocompetent BALB/c and C57BL/6 mice. Immunobiology (2010) 0.76
Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells. Nitric Oxide (2008) 0.76
Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis. Neurochem Int (2009) 0.76
Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO. Free Radic Biol Med (2010) 0.76
[Acute perforated eardrum - patching with hyaluronic acid or spontaneous healing?]. Laryngorhinootologie (2014) 0.75
N,N'-Bis[2-(methoxycarbonyl)ethyl]ethane-1,2-diammonium dichloride. Acta Crystallogr Sect E Struct Rep Online (2008) 0.75
Dibromidodimethyl-dipyridine-platinum(IV). Acta Crystallogr Sect E Struct Rep Online (2008) 0.75
Study of the cytotoxicity and particle action in human cancer cells of titanocene-functionalized materials with potential application against tumors. J Inorg Biochem (2011) 0.75
Saquinavir-NO-targeted S6 protein mediates sensitivity of androgen-dependent prostate cancer cells to TRAIL. Cell Cycle (2012) 0.75
Biological activity of neutral and cationic iridium(III) complexes with κP and κP,κS coordinated Ph₂PCH₂S(O)xPh (x = 0-2) ligands. Eur J Med Chem (2013) 0.75
Platinum(II) complexes with l-methionylglycine and l-methionyl-l-leucine ligands: synthesis, characterization and in vitro antitumoral activity. J Inorg Biochem (2006) 0.75
Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N'-diacetate. J Inorg Biochem (2013) 0.75
The relevance of the migration inhibitory factor (MIF) for peripheral tissue response in murine sublethal systemic Aspergillus fumigatus infection. Med Mycol (2012) 0.75
Synthesis, cytotoxic and hydrolytic studies of titanium complexes anchored by a tripodal diamine bis(phenolate) ligand. Dalton Trans (2014) 0.75
Palladium(II) complexes with R2edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R2eddip esters and palladium(II) complexes. Eur J Med Chem (2009) 0.75
Preliminary study of the anticancer applications of mesoporous materials functionalized with the natural product betulinic acid. ChemMedChem (2012) 0.75
Correction: Synthesis, cytotoxic and hydrolytic studies of titanium complexes anchored by a tripodal diamine bis(phenolate) ligand. Dalton Trans (2015) 0.75
Melanoma tumor inhibition by tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations. Metallomics (2012) 0.75
Ribavirin administration alters ectonucleotidase activities in experimental autoimmune encephalomyelitis. Gen Physiol Biophys (2009) 0.75
A multicomponent macrocyclization strategy to natural product-like cyclic lipopeptides: synthesis and anticancer evaluation of surfactin and mycosubtilin analogues. Org Biomol Chem (2017) 0.75
Formation of ortho-cyano-aminothiophenolate ligands with versatile binding modes via facile carbon-sulfur bond cleavage of 2-aminobenzothiazoles at mercury(II) centres. Dalton Trans (2015) 0.75
Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph3Sn(CH2)3OH against the A2780 ovarian carcinoma cell line. Dalton Trans (2016) 0.75
Alkylthio bridged 44 cve triangular platinum clusters: synthesis, oxidation, degradation, ligand substitution, and quantum chemical calculations. J Am Chem Soc (2007) 0.75
The novel NO-donating compound GIT-27NO inhibits in vivo growth of human prostate cancer cells and prevents murine immunoinflammatory hepatitis. Eur J Pharmacol (2009) 0.75
Organotin(IV)-loaded mesoporous silica as a biocompatible strategy in cancer treatment. Angew Chem Int Ed Engl (2014) 0.75
Splenic and lung response to nonlethal systemic Aspergillus fumigatus infection in C57BL/6 mice. Med Mycol (2010) 0.75