Published in J Clin Invest on April 20, 2015
Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury. Sci Transl Med (2016) 1.44
Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation. Alzheimers Dement (2016) 1.42
Phagocytosis of apoptotic cells in homeostasis. Nat Immunol (2015) 1.20
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). J Biol Chem (2015) 1.04
The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis. Nat Immunol (2015) 1.03
The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E. J Biol Chem (2015) 1.03
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nat Rev Neurosci (2016) 0.97
TREM2 in CNS homeostasis and neurodegenerative disease. Mol Neurodegener (2015) 0.89
Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD). J Nat Sci (2015) 0.86
Age-related myelin degradation burdens the clearance function of microglia during aging. Nat Neurosci (2016) 0.86
Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease. Trends Neurosci (2015) 0.85
Immune Surveillance of the CNS following Infection and Injury. Trends Immunol (2015) 0.81
Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease. J Neurosci (2017) 0.80
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. Elife (2016) 0.79
Central Nervous System: (Immunological) Ivory Tower or Not? Neuropsychopharmacology (2016) 0.79
Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation. Curr Opin Pharmacol (2015) 0.78
Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia. J Neuroinflammation (2016) 0.77
Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target. Mol Neurobiol (2016) 0.77
Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair. Front Cell Dev Biol (2016) 0.77
Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury. J Physiol (2016) 0.77
Regulation of microglial survival and proliferation in health and diseases. Semin Immunol (2016) 0.76
Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration. Acta Neuropathol (2016) 0.75
The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein Stability. Front Neurosci (2017) 0.75
TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis. Nat Commun (2016) 0.75
TREM2-ligand interactions in health and disease. J Mol Biol (2017) 0.75
The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. J Neuroinflammation (2017) 0.75
TREM2 promotes microglial survival by activating Wnt/β-catenin pathway. J Neurosci (2017) 0.75
A mouse model for testing remyelinating therapies. Exp Neurol (2016) 0.75
Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain. Front Mol Neurosci (2017) 0.75
TREM2 in Neurodegenerative Diseases. Mol Neurodegener (2017) 0.75
Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype. Front Neurosci (2017) 0.75
The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved? Metab Brain Dis (2017) 0.75
Lipid rafts as a membrane-organizing principle. Science (2010) 13.48
TREM2 variants in Alzheimer's disease. N Engl J Med (2012) 11.35
Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med (2012) 10.16
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci (2007) 7.42
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol (2011) 6.53
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci (2007) 6.23
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45
Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am J Hum Genet (2002) 4.06
Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci (2013) 3.94
The myeloid cells of the central nervous system parenchyma. Nature (2010) 3.80
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci (2013) 3.59
The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol (2001) 3.47
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med (2005) 3.42
A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J Exp Med (2001) 3.18
Cutting edge: TREM-2 attenuates macrophage activation. J Immunol (2006) 3.07
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci (2011) 3.06
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest (2003) 2.79
The microglial sensome revealed by direct RNA sequencing. Nat Neurosci (2013) 2.73
Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol (2006) 2.73
TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med (2007) 2.62
Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation. J Neurosci (2006) 2.44
TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol (2009) 2.44
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell (2015) 2.15
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med (2014) 2.05
Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia. J Neurochem (2002) 2.00
Interleukin-1beta promotes repair of the CNS. J Neurosci (2001) 1.92
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin. Nat Immunol (2009) 1.88
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Mol Neurodegener (2013) 1.83
Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol (2001) 1.78
DAP10- and DAP12-associated receptors in innate immunity. Immunol Rev (2009) 1.76
Pattern recognition by TREM-2: binding of anionic ligands. J Immunol (2003) 1.73
Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia. Eur J Neurosci (2004) 1.71
Age and gender effects on microglia and astrocyte numbers in brains of mice. Brain Res (2002) 1.67
TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. JAMA Neurol (2014) 1.63
Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Am J Pathol (2008) 1.54
Identification of a microglia phenotype supportive of remyelination. Glia (2011) 1.51
Age-related alterations in the dynamic behavior of microglia. Aging Cell (2010) 1.49
TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol (2009) 1.45
Specific lipid recognition is a general feature of CD300 and TREM molecules. Immunogenetics (2011) 1.30
Development and homeostasis of "resident" myeloid cells: the case of the microglia. Glia (2012) 1.30
TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis. J Immunol (2012) 1.30
Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices. Glia (2012) 1.26
NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. Proc Natl Acad Sci U S A (2004) 1.25
Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage. J Biol Chem (2013) 1.24
Nasu-Hakola syndrome: polycystic lipomembranous osteodysplasia with sclerosing leucoencephalopathy and presenile dementia. J Med Genet (1997) 1.24
Regulation of microglia development and homeostasis. Glia (2012) 1.19
Characterisation of microglia during de- and remyelination: can they create a repair promoting environment? Neurobiol Dis (2011) 1.07
Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology (2014) 1.03
Blood-brain barrier permeability to horseradish peroxidase in twitcher and cuprizone-intoxicated mice. Brain Res (1987) 1.00
Axonal selection and myelin sheath generation in the central nervous system. Curr Opin Cell Biol (2013) 0.95
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned. Front Cell Neurosci (2014) 0.93
Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity. Brain Res (2008) 0.92
Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response. Gastroenterology (2012) 0.90
Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming. PLoS One (2011) 0.89
A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages. Sci Signal (2013) 0.86
Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant. Exp Neurol (2008) 0.82
Myelin vesicles: what we know and what we do not know. J Neurosci Res (1995) 0.80
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature (2008) 8.22
Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol (2013) 7.94
A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature (2010) 5.45
Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol (2006) 4.87
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity (2004) 4.50
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med (2009) 4.27
Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity (2004) 4.11
Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity (2008) 4.07
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood (2003) 3.98
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature (2003) 3.87
Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. Immunity (2013) 3.51
Cutting edge: TREM-2 attenuates macrophage activation. J Immunol (2006) 3.07
The TREM receptor family and signal integration. Nat Immunol (2006) 3.06
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol (2011) 2.99
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med (2009) 2.92
NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol (2002) 2.92
Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice. Proc Natl Acad Sci U S A (2007) 2.81
NK cell and DC interactions. Trends Immunol (2004) 2.68
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol (2012) 2.62
The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine. Proc Natl Acad Sci U S A (2008) 2.57
Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. Immunity (2010) 2.56
Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev (2010) 2.55
Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo. J Exp Med (2002) 2.47
Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol (2004) 2.44
Influenza virus targets the mRNA export machinery and the nuclear pore complex. Proc Natl Acad Sci U S A (2007) 2.44
A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol (2003) 2.42
Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity. Proc Natl Acad Sci U S A (2010) 2.35
Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Proc Natl Acad Sci U S A (2003) 2.33
HLA alleles determine differences in human natural killer cell responsiveness and potency. Proc Natl Acad Sci U S A (2008) 2.31
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Nat Genet (2013) 2.06
Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. Dev Cell (2008) 2.00
DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J Exp Med (2008) 2.00
B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. J Immunol (2008) 1.96
Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12. Blood (2005) 1.94
Efficient colonic mucosal wound repair requires Trem2 signaling. Proc Natl Acad Sci U S A (2008) 1.93
Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas. Cancer Res (2006) 1.89
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin. Nat Immunol (2009) 1.88
Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis. Eur J Immunol (2007) 1.88
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol (2013) 1.87
Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. J Exp Med (2010) 1.86
Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3. Blood (2005) 1.83
Impaired differentiation of osteoclasts in TREM-2-deficient individuals. J Exp Med (2003) 1.80
Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells. J Exp Med (2007) 1.76
Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science (2003) 1.73
Evidence for MR1 antigen presentation to mucosal-associated invariant T cells. J Biol Chem (2005) 1.72
Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia. Eur J Neurosci (2004) 1.71
MR1-restricted V alpha 19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response. J Immunol (2006) 1.69
Activating and inhibitory functions of DAP12. Nat Rev Immunol (2007) 1.69
MDA-5 recognition of a murine norovirus. PLoS Pathog (2008) 1.68
Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells. J Exp Med (2009) 1.67
MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells. J Exp Med (2008) 1.67
A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome. J Clin Invest (2007) 1.67
Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. PLoS Pathog (2010) 1.66
Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J Clin Invest (2012) 1.66
Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways. Eur J Immunol (2005) 1.62
Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol (2005) 1.61
Hidden talents of natural killers: NK cells in innate and adaptive immunity. EMBO Rep (2009) 1.60
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology (2013) 1.57
Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection. Cell Host Microbe (2012) 1.54
Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells. J Exp Med (2003) 1.54
Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med (2010) 1.54
Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol (2005) 1.53
Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas. J Pathol (2003) 1.53
Plasmacytoid dendritic cells--virus experts of innate immunity. Semin Immunol (2005) 1.52
IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease. J Clin Invest (2015) 1.51
Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells. Blood (2005) 1.50
Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation. J Biol Chem (2012) 1.50
CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion. J Cell Biol (2006) 1.49
MerTK is required for apoptotic cell-induced T cell tolerance. J Exp Med (2008) 1.48
The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood (2005) 1.46
NK cells recognize and kill human glioblastoma cells with stem cell-like properties. J Immunol (2009) 1.46
The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance. Semin Cancer Biol (2006) 1.45
TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol (2009) 1.45
Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia. J Immunol (2004) 1.45
Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation. J Immunol (2005) 1.42
The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). Hum Mol Genet (2010) 1.42
Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44. Blood (2005) 1.41
Electroclinical findings in four patients with karyotype 47,XYY. Brain Dev (2010) 1.41
Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset. Microbes Infect (2005) 1.40
The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis. J Virol (2009) 1.39
Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo. J Exp Med (2011) 1.39