Published in Science on September 12, 2003
A role for IgG immune complexes during infection with the intracellular pathogen Leishmania. J Exp Med (2005) 2.50
Negative signaling by inhibitory receptors: the NK cell paradigm. Immunol Rev (2008) 2.40
NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages. J Biol Chem (2006) 2.29
Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class I in Northeast Asians. Am J Hum Genet (2008) 1.60
Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe (2009) 1.55
Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest (2008) 1.54
Regulation of T-cell immunity by leucocyte immunoglobulin-like receptors: innate immune receptors for self on antigen-presenting cells. Immunology (2009) 1.23
Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for Th1/Th2 polarization. BMC Immunol (2009) 1.21
NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nat Med (2012) 1.14
The innate immune response in leprosy. Curr Opin Immunol (2010) 1.12
Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev (2010) 1.02
LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J Immunol (2007) 1.01
Integrated pathways for neutrophil recruitment and inflammation in leprosy. J Infect Dis (2010) 1.00
Differential cytokine gene expression profiles in the three pathological forms of sheep paratuberculosis. BMC Vet Res (2007) 1.00
Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines. Hum Immunol (2009) 1.00
Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations. J Hum Genet (2015) 0.98
Gene expression profiles of bronchoalveolar cells in pulmonary TB. Tuberculosis (Edinb) (2007) 0.98
Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis. PLoS Negl Trop Dis (2011) 0.96
Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth. BMC Med Genomics (2009) 0.95
Mycobacterium leprae actively modulates the cytokine response in naive human monocytes. Infect Immun (2009) 0.95
Mannan-binding lectin plasma levels in leprosy: deficiency confers protection against the lepromatous but not the tuberculoid forms. Clin Exp Immunol (2006) 0.93
The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection. BMC Immunol (2009) 0.93
The impact of the myeloid response to radiation therapy. Clin Dev Immunol (2013) 0.92
Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers. Infect Immun (2007) 0.92
LILRA2 selectively modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytes. PLoS One (2012) 0.90
Transcriptome patterns from primary cutaneous Leishmania braziliensis infections associate with eventual development of mucosal disease in humans. PLoS Negl Trop Dis (2012) 0.88
Dynamic changes in the subgingival microbiome and their potential for diagnosis and prognosis of periodontitis. MBio (2015) 0.88
Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori. J Immunol (2014) 0.87
Decreased Th1-type inflammatory cytokine expression in the skin is associated with persisting symptoms after treatment of erythema migrans. PLoS One (2011) 0.86
Polymorphism of the 5' flanking region of the IL-12 receptor beta2 gene partially determines the clinical types of leprosy through impaired transcriptional activity. J Clin Pathol (2005) 0.85
Matrix factorisation methods applied in microarray data analysis. Int J Data Min Bioinform (2010) 0.85
Modulation of Toll-like receptor activity by leukocyte Ig-like receptors and their effects during bacterial infection. Mediators Inflamm (2010) 0.84
Elevated IP-10 and IL-6 from bronchoalveolar lavage cells are biomarkers of non-cavitary tuberculosis. Int J Tuberc Lung Dis (2013) 0.84
Lymphotoxin-alpha and TNF have essential but independent roles in the evolution of the granulomatous response in experimental leprosy. Am J Pathol (2009) 0.82
Differential dermal expression of CCL17 and CCL18 in tuberculoid and lepromatous leprosy. PLoS Negl Trop Dis (2014) 0.81
Genome-Wide Screening of mRNA Expression in Leprosy Patients. Front Genet (2015) 0.80
Characterisation of bovine leukocyte Ig-like receptors. PLoS One (2012) 0.80
RNA-sequence analysis of primary alveolar macrophages after in vitro infection with porcine reproductive and respiratory syndrome virus strains of differing virulence. PLoS One (2014) 0.80
Transcriptional changes that characterize the immune reactions of leprosy. J Infect Dis (2014) 0.79
Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese. Genes Immun (2014) 0.79
Leukocyte Ig-Like Receptors - A Model for MHC Class I Disease Associations. Front Immunol (2016) 0.79
Association of cytokine gene polymorphism with susceptibility and clinical types of leprosy. Int J Health Sci (Qassim) (2007) 0.78
Geographical heterogeneity in the analysis of factors associated with leprosy in an endemic area of Brazil: are we eliminating the disease? BMC Infect Dis (2015) 0.78
Effect of apoptotic cell recognition on macrophage polarization and mycobacterial persistence. Infect Immun (2014) 0.78
SARS-CoV regulates immune function-related gene expression in human monocytic cells. Viral Immunol (2012) 0.77
CARD15 status and familial predisposition for Crohn's disease and colonic gene expression. Dig Dis Sci (2007) 0.77
The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy. Infect Dis Poverty (2017) 0.76
Galectin-3 regulates the innate immune response of human monocytes. J Infect Dis (2012) 0.76
A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy. Immunology (2010) 0.76
Human Genetic Ancestral Composition Correlates with the Origin of Mycobacterium leprae Strains in a Leprosy Endemic Population. PLoS Negl Trop Dis (2015) 0.76
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy. JCI Insight (2016) 0.75
Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure. Sci Rep (2016) 0.75
The balance of metagenomic elements shapes the skin microbiome in acne and health. Sci Rep (2016) 0.75
In-silico modeling of granulomatous diseases. Curr Opin Pulm Med (2016) 0.75
Dysregulation of serum gamma interferon levels in vascular chronic Q Fever patients provides insights into disease pathogenesis. Clin Vaccine Immunol (2015) 0.75
Leukocyte immunoglobulin-like receptors in human diseases: an overview of their distribution, function, and potential application for immunotherapies. J Leukoc Biol (2017) 0.75
Clinical and genomic responses to ultra-short course chemotherapy in spinal tuberculosis. Exp Ther Med (2017) 0.75
The Database of Interacting Proteins: 2004 update. Nucleic Acids Res (2004) 23.67
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74
The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol (2004) 16.08
DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res (2002) 15.70
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99
Structure of the cross-beta spine of amyloid-like fibrils. Nature (2005) 11.56
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature (2011) 10.77
Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature (2007) 10.02
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27
The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol (2007) 8.24
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature (2008) 8.22
Protein interactions: two methods for assessment of the reliability of high throughput observations. Mol Cell Proteomics (2002) 8.11
Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions. BMC Biol (2007) 8.03
Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol (2013) 7.94
Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 7.29
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83
Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell (2003) 6.38
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A (2003) 5.83
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol (2002) 5.48
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science (2013) 5.10
PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods (2011) 5.01
Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol (2006) 4.87
Ipr1 gene mediates innate immunity to tuberculosis. Nature (2005) 4.53
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity (2004) 4.50
Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol (2007) 4.44
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell (2011) 4.43
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci U S A (2005) 4.43
3D domain swapping: as domains continue to swap. Protein Sci (2002) 4.35
MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity (2006) 4.28
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med (2009) 4.27
Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity (2004) 4.11
Prolinks: a database of protein functional linkages derived from coevolution. Genome Biol (2004) 4.07
Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity (2008) 4.07
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood (2003) 3.98
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest (2007) 3.82
Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science (2009) 3.78
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature (2011) 3.63
Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity (2007) 3.61
Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. Immunity (2013) 3.51
Identifying the amylome, proteins capable of forming amyloid-like fibrils. Proc Natl Acad Sci U S A (2010) 3.50
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest (2010) 3.40
The origin of protein interactions and allostery in colocalization. Nature (2007) 3.34
Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol (2013) 3.32
Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med (2011) 3.27
Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Nat Med (2003) 3.24
Atomic view of a toxic amyloid small oligomer. Science (2012) 3.13
Susceptibility to leprosy is associated with PARK2 and PACRG. Nature (2004) 3.07
Cutting edge: TREM-2 attenuates macrophage activation. J Immunol (2006) 3.07
The TREM receptor family and signal integration. Nat Immunol (2006) 3.06
Continuation and satisfaction of reversible contraception. Obstet Gynecol (2011) 3.03
Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure. Nature (2005) 2.99
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol (2011) 2.99
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med (2009) 2.92
NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol (2002) 2.92
Inference of protein function from protein structure. Structure (2005) 2.90
The 3D profile method for identifying fibril-forming segments of proteins. Proc Natl Acad Sci U S A (2006) 2.88
Computational methods of analysis of protein-protein interactions. Curr Opin Struct Biol (2003) 2.80
Describing biological protein interactions in terms of protein states and state transitions: the LiveDIP database. Mol Cell Proteomics (2002) 2.76
Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat Genet (2009) 2.76
NK cell and DC interactions. Trends Immunol (2004) 2.68
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med (2005) 2.62
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol (2012) 2.62
The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine. Proc Natl Acad Sci U S A (2008) 2.57
Toward rational protein crystallization: A Web server for the design of crystallizable protein variants. Protein Sci (2007) 2.57
Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. Immunity (2010) 2.56
Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev (2010) 2.55
Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis. Arthritis Rheum (2004) 2.52
Toll-like receptors induce a phagocytic gene program through p38. J Exp Med (2003) 2.49
Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo. J Exp Med (2002) 2.47
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature (2011) 2.46
Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. J Immunol (2009) 2.45
Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol (2004) 2.44
Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Mol Biol (2007) 2.42
A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol (2003) 2.42
Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth. Proc Natl Acad Sci U S A (2002) 2.41
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev (2011) 2.38
Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol (2010) 2.38
Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity. Proc Natl Acad Sci U S A (2010) 2.35
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science (2013) 2.34