Published in Chin Med J (Engl) on May 20, 2015
Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med (2001) 51.99
Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med (1985) 11.68
Lactate and venoarterial carbon dioxide difference/arterial-venous oxygen difference ratio, but not central venous oxygen saturation, predict increase in oxygen consumption in fluid responders. Crit Care Med (2013) 3.72
Anion gap and hypoalbuminemia. Crit Care Med (1998) 3.67
Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study. Lancet (2005) 2.35
Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet (1999) 2.14
Venoarterial CO(2) difference during regional ischemic or hypoxic hypoxia. J Appl Physiol (1985) (2000) 1.84
A prospective study of the use of a dobutamine stress test to identify outcome in patients with sepsis, severe sepsis, or septic shock. Crit Care Med (1999) 1.70
The strong ion gap predicts mortality in children following cardiopulmonary bypass surgery. Pediatr Crit Care Med (2005) 1.68
Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med (2009) 1.62
Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clin (2001) 1.58
Early acid-base and blood pressure effects of continuous renal replacement therapy intensity in patients with metabolic acidosis. Intensive Care Med (2013) 1.46
Early markers of major adverse events in children after cardiac operations. J Thorac Cardiovasc Surg (1997) 1.43
Combination of venoarterial PCO2 difference with arteriovenous O2 content difference to detect anaerobic metabolism in patients. Intensive Care Med (2002) 1.36
Meaning of arterio-venous PCO2 difference in circulatory shock. Minerva Anestesiol (2006) 1.18
The effects of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients. N Engl J Med (1987) 1.18
Serum lactates correlate with mortality after operations for complex congenital heart disease. Ann Thorac Surg (1997) 1.12
Low and "supranormal" central venous oxygen saturation and markers of tissue hypoxia in cardiac surgery patients: a prospective observational study. Intensive Care Med (2010) 1.10
Oxygen consumption and blood flow in resting mammalian skeletal muscle. Am J Physiol (1974) 1.08
Arteriovenous differences in PCO2 and pH are good indicators of critical hypoperfusion. Am Rev Respir Dis (1993) 1.08
Postoperative lactate concentrations predict the outcome of infants aged 6 weeks or less after intracardiac surgery: a cohort follow-up to 18 months. J Thorac Cardiovasc Surg (2005) 1.05
Oxygen supply dependency can characterize septic shock. Intensive Care Med (1998) 1.03
Anaerobic CO2 production by dog kidney in vitro. Am J Physiol (1966) 0.95
'Lactate washout' following circulatory arrest. JAMA (1988) 0.94
Detection of tissue hypoxia by arteriovenous gradient for PCO2 and pH in anesthetized dogs during progressive hemorrhage. Anesth Analg (1995) 0.92
Suppression of shivering decreases oxygen consumption and improves hemodynamic stability during postoperative rewarming. Ann Thorac Surg (1987) 0.92
Temperature and ventilation after hypothermic cardiopulmonary bypass. Anesth Analg (1985) 0.87
Combining central venous-to-arterial partial pressure of carbon dioxide difference and central venous oxygen saturation to guide resuscitation in septic shock. J Crit Care (2013) 0.84
Pulmonary lactate release following cardiopulmonary bypass. Eur J Cardiothorac Surg (2007) 0.84
Blood cardioplegia provides superior protection in infant cardiac surgery. Ann Thorac Surg (2005) 0.83
Should we use central venous saturation to guide management in high-risk surgical patients? Crit Care (2006) 0.83
Unmeasured anions in children after cardiac surgery. J Thorac Cardiovasc Surg (2007) 0.80
Continuous monitoring of oxygen consumption in patients undergoing weaning from mechanical ventilation. Respiration (2004) 0.79
Renal effects of amino acid infusion in cardiac surgery. J Cardiothorac Vasc Anesth (2000) 0.79
Effects of histamine, acetylcholine, and norepinephrine on gastric vascular resistance. Am J Physiol (1963) 0.78
Transpulmonary lactate gradient after hypothermic cardiopulmonary bypass. Intensive Care Med (2004) 0.78
Effects of anesthetic agents on systemic critical O2 delivery. J Appl Physiol (1985) (1991) 0.77
Hypermetabolism after coronary artery bypass. J Thorac Cardiovasc Surg (1991) 0.76
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest (2007) 2.81
Factors associated with breast cancer clinical trials participation and enrollment at a large academic medical center. J Clin Oncol (2004) 2.55
Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature (2002) 2.40
Regression equations for calculation of z scores of cardiac structures in a large cohort of healthy infants, children, and adolescents: an echocardiographic study. J Am Soc Echocardiogr (2008) 2.38
Perspectives of microbial oils for biodiesel production. Appl Microbiol Biotechnol (2008) 2.25
Molecular classification of cancer types from microarray data using the combination of genetic algorithms and support vector machines. FEBS Lett (2003) 1.90
Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection. Cell Host Microbe (2009) 1.78
Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proc Natl Acad Sci U S A (2006) 1.77
Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake. J Biol Chem (2005) 1.75
Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position. Eur J Med Chem (2006) 1.65
Tunnel propagation following defibrillation with ICD shocks: hidden postshock activations in the left ventricular wall underlie isoelectric window. Heart Rhythm (2010) 1.64
Sleep-deprived young drivers and the risk for crash: the DRIVE prospective cohort study. JAMA Pediatr (2013) 1.59
Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae bloodstream infection: risk factors and clinical outcome. Intensive Care Med (2002) 1.53
Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery. Dis Colon Rectum (2005) 1.50
Establishment and evaluation of a swine model of acute myocardial infarction and reperfusion-ventricular fibrillation-cardiac arrest using the interventional technique. J Chin Med Assoc (2013) 1.47
Alvimopan, for postoperative ileus following bowel resection: a pooled analysis of phase III studies. Ann Surg (2007) 1.46
Standardizing radiation dose reporting in the pediatric cardiac catheterization laboratory-a multicenter study by the CCISC (Congenital Cardiovascular Interventional Study Consortium). Catheter Cardiovasc Interv (2014) 1.44
Gastrointestinal tract recovery in patients undergoing bowel resection: results of a randomized trial of alvimopan and placebo with a standardized accelerated postoperative care pathway. Arch Surg (2008) 1.43
Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell (2010) 1.42
Left ventricular systolic dyssynchrony in pediatric and adolescent patients with congestive heart failure. J Am Soc Echocardiogr (2012) 1.40
Comparison of surgical, stent, and balloon angioplasty treatment of native coarctation of the aorta: an observational study by the CCISC (Congenital Cardiovascular Interventional Study Consortium). J Am Coll Cardiol (2011) 1.39
Trans-catheter closure of patent ductus arteriosus-What is the best device? Catheter Cardiovasc Interv (2010) 1.35
Twenty-year trends in the prevalence of disability in China. Bull World Health Organ (2011) 1.34
Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett (2010) 1.33
Procedural results and acute complications in stenting native and recurrent coarctation of the aorta in patients over 4 years of age: a multi-institutional study. Catheter Cardiovasc Interv (2007) 1.30
Acute renal failure during sepsis: potential role of cell cycle regulation. J Infect (2009) 1.26
Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice. Proc Natl Acad Sci U S A (2003) 1.25
Prevalence rates of helmet use among motorcycle riders in a developed region in China. Accid Anal Prev (2010) 1.25
Intratumoral heterogeneity determines discordant results of diagnostic tests for human epidermal growth factor receptor (HER) 2 in gastric cancer specimens. Cell Biochem Biophys (2012) 1.25
The evolution of courtship behaviors through the origination of a new gene in Drosophila. Proc Natl Acad Sci U S A (2008) 1.23
Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J (2003) 1.23
Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development (2006) 1.22
Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells. Cancer Lett (2009) 1.21
Genome-wide linkage scan identifies a novel genetic locus on chromosome 5p13 for neonatal atrial fibrillation associated with sudden death and variable cardiomyopathy. Circulation (2004) 1.21
Chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cells. Anticancer Res (2008) 1.20
Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol (2008) 1.20
Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling. Int J Oncol (2010) 1.18
Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells. Int J Oncol (2008) 1.15
Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc Natl Acad Sci U S A (2004) 1.15
Conserved RB functions in development and tumor suppression. Protein Cell (2011) 1.15
Alvimopan: an oral, peripherally acting, mu-opioid receptor antagonist for the treatment of opioid-induced bowel dysfunction--a 21-day treatment-randomized clinical trial. J Pain (2005) 1.14
Intermediate follow-up following intravascular stenting for treatment of coarctation of the aorta. Catheter Cardiovasc Interv (2007) 1.13
The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development (2002) 1.13
Highly enantioselective michael addition of cyclic 1,3-dicarbonyl compounds to alpha,beta-unsaturated ketones. Org Lett (2007) 1.10
Enantioselective 1,3-dipolar cycloaddition of cyclic enones catalyzed by multifunctional primary amines: beneficial effects of hydrogen bonding. Angew Chem Int Ed Engl (2007) 1.10
Neoadjuvant docetaxel and estramustine chemotherapy in high-risk/locallyadvanced prostate cancer. Urology (2003) 1.10
Effect of alvimopan and codeine on gastrointestinal transit: a randomized controlled study. Clin Gastroenterol Hepatol (2005) 1.08
Improving surgical outcomes: standardizing the reporting of incidence and severity of acute lymphedema after sentinel lymph node biopsy and axillary lymph node dissection. Am J Surg (2006) 1.08
Highly asymmetric Michael addition to alpha,beta-unsaturated ketones catalyzed by 9-amino-9-deoxyepiquinine. Angew Chem Int Ed Engl (2007) 1.06
A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients. J Neurol Sci (2012) 1.05
ABCB6 mutations cause ocular coloboma. Am J Hum Genet (2012) 1.04
Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells. Int J Oncol (2007) 1.04
Evaluation of left ventricular diastolic function in pediatric sickle cell disease patients. Am J Hematol (2007) 1.04
Oxidative stress-specific interaction between FANCD2 and FOXO3a. Blood (2009) 1.04
Patterns of gastrointestinal recovery after bowel resection and total abdominal hysterectomy: pooled results from the placebo arms of alvimopan phase III North American clinical trials. J Am Coll Surg (2007) 1.03
Effector mechanisms of the anti-cancer immune responses of macrophages in SR/CR mice. Cancer Immun (2006) 1.02
Modulations of functional connectivity in the healthy and schizophrenia groups during task and rest. Neuroimage (2012) 1.02
Postoperative ileus-related morbidity profile in patients treated with alvimopan after bowel resection. J Am Coll Surg (2007) 1.02
Detecting novel low-abundant transcripts in Drosophila. RNA (2005) 1.02
A human bone morphogenetic protein antagonist is down-regulated in renal cancer. Mol Biol Cell (2007) 1.01
The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice. Ann N Y Acad Sci (2008) 1.01
Proneural basic helix-loop-helix proteins and epidermal growth factor receptor signaling coordinately regulate cell type specification and cdk inhibitor expression during development. Mol Cell Biol (2007) 1.01
Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. Brain Res (2002) 1.01
Transition zone PSA density improves the prostate cancer detection rate both in PSA 4.0-10.0 and 10.1-20.0 ng/ml in Chinese men. Urol Oncol (2011) 1.01
Overexpression of the progestagen-associated endometrial protein gene is associated with microphthalmia-associated transcription factor in human melanoma. Ochsner J (2011) 0.99
Miconazole induces changes in actin cytoskeleton prior to reactive oxygen species induction in yeast. J Biol Chem (2007) 0.99
Clinical efficacy and safety of IV ferric carboxymaltose (FCM) treatment of RLS: a multi-centred, placebo-controlled preliminary clinical trial. Sleep Med (2011) 0.98
A double-blind, randomized, placebo-controlled phase III study of the safety of alvimopan in patients who undergo simple total abdominal hysterectomy. Am J Obstet Gynecol (2006) 0.97
Organocatalytic stereoselective mannich reaction of 3-substituted oxindoles. Org Lett (2008) 0.97
Direct control of the proneural gene atonal by retinal determination factors during Drosophila eye development. Dev Biol (2007) 0.96
The disturbance of small RNA pathways enhanced abscisic acid response and multiple stress responses in Arabidopsis. Plant Cell Environ (2008) 0.96
In vitro and in vivo anticancer effects of American ginseng berry: exploring representative compounds. Biol Pharm Bull (2009) 0.96
Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. Int J Oncol (2013) 0.96
Patterns of drug utilization in a neonatal intensive care unit. J Clin Pharmacol (2006) 0.96
Role for RhoB and PRK in the suppression of epithelial cell transformation by farnesyltransferase inhibitors. Oncogene (2003) 0.96
Traditional Chinese medicine for pressure ulcer: a meta-analysis. Int Wound J (2012) 0.95
Baicalein is neuroprotective in rat MCAO model: role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2. Pharmacol Biochem Behav (2010) 0.95
Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Brain Res (2010) 0.95
Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica (2013) 0.94
All-optical tuning of a nonlinear silicon microring assisted microwave photonic filter: theory and experiment. Opt Express (2015) 0.94
Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. Int J Mol Sci (2013) 0.94
Motorcycle protective clothing: protection from injury or just the weather? Accid Anal Prev (2011) 0.94
Vitamin D deficiency is associated with increased left ventricular mass and diastolic dysfunction in children with chronic kidney disease. Pediatr Cardiol (2012) 0.94
Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection. Vaccine (2011) 0.93
Respiratory complications after major surgery. Curr Opin Crit Care (2009) 0.93
Organocatalytic and highly enantioselective direct alpha-amination of aromatic ketones. Org Lett (2007) 0.93
PTD4-apoptin protein therapy inhibits tumor growth in vivo. Int J Cancer (2009) 0.93
A new novel mutation in FBN1 causes autosomal dominant Marfan syndrome in a Chinese family. Mol Vis (2012) 0.92
Isolation and characterization of ZZ1, a novel lytic phage that infects Acinetobacter baumannii clinical isolates. BMC Microbiol (2012) 0.92
A prospective observational multicenter study of balloon angioplasty for the treatment of native and recurrent coarctation of the aorta. Catheter Cardiovasc Interv (2013) 0.92
Zelrix: a novel transdermal formulation of sumatriptan. Headache (2009) 0.92
The peripheral perfusion index and transcutaneous oxygen challenge test are predictive of mortality in septic patients after resuscitation. Crit Care (2013) 0.92
Phase II trial of estramustine and etoposide in androgen-sensitive metastatic prostate carcinoma. Am J Clin Oncol (2004) 0.92
ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice. J Immunol (2008) 0.92
Microfluidic chip: next-generation platform for systems biology. Anal Chim Acta (2009) 0.91
Development of a porcine deep partial thickness burn model. Burns (2012) 0.91
Structural analysis of water and carbon tetrachloride adsorbed in activated carbon fibres. Phys Chem Chem Phys (2012) 0.91
Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways. Oncol Rep (2013) 0.91