Early goal-directed therapy in the treatment of severe sepsis and septic shock.

PubWeight™: 51.99‹?› | Rank: Top 0.01% | All-Time Top 1000

🔗 View Article (PMID 11794169)

Published in N Engl J Med on November 08, 2001

Authors

E Rivers1, B Nguyen, S Havstad, J Ressler, A Muzzin, B Knoblich, E Peterson, M Tomlanovich, Early Goal-Directed Therapy Collaborative Group

Author Affiliations

1: Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA. erivers1@hfhs.org

Associated clinical trials:

Protocolized Care for Early Septic Shock (ProCESS) | NCT00510835

Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests | NCT00258869

BaSES Trial: Basel Starch Evaluation in Sepsis (BaSES) | NCT00273728

Early Lactate-Directed Therapy in the Intensive Care Unit (ICU) | NCT00270673

Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis | NCT00608322

Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study (StePS) | NCT00732277

Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by Ivabradine (MODIfY) | NCT01186783

Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock (MiCHO) | NCT00535821

Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock | NCT02473718

Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate in the Intensive Care Unit | NCT01624519

Critical Care Excellence in Sepsis and Trauma (CREST) | NCT01426711

Emergency Department (ED) Flow-directed Fluid Optimization Resuscitation Trial (EFFORT) (EFFORT) | NCT01128413

Hemodynamics and Extravascular Lung Water in Acute Lung Injury (HEAL) | NCT00624650

Restricted Fluid Regimen in Open Abdominal Bowel Surgery | NCT00456703

Restrictive Intravenous Fluids Trial in Sepsis (RIFTS) | NCT03137446

Management of Cardiogenic Pulmonary Edema (RENAU-OAP) (RENAU-OAP) | NCT03148847

Extension of the RUSH Protocol for Volume Responsiveness | NCT03285269

Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock (GOAL) | NCT03461900

Hemodynamic Optimization Through Pleth Variability Index for OHCA (HemOpt-PVI) | NCT03841708

EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock | NCT04134624

Volume Responsiveness By Ultrasound Of Carotid Blood Flow In Patients With Cardiogenic Shock | NCT05271227

Carotid VTI as a Measure of Intravascular Volume Status During Lower Body Negative Pressure Simulation | NCT02907931

Description of Fluid Balance in Patients With Acute Respiratory Failure | NCT02523872

Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock (SSS) | NCT02473263

PPV to Guide Fluid Management in the PICU (PPV) | NCT02308371

Oxygen Consumption in Critical Illness | NCT02163109

Comparing USCOM and Echocardiographic Hemodynamic Measurements in Children (CUE Study) | NCT02083172

Statistical Analysis Plan for an Individual Patient Data Meta-analysis of Three, International Trials Comparing Protocolised With Usual Resuscitation in Patients Presenting to the Emergency Department With Severe Sepsis and Septic Shock | NCT02030158

Lactate Clearance According to the Presence of Hepatic Dysfunction | NCT01709565

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