Published in Clin Cancer Res on May 19, 2015
3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation. Nanomedicine (2015) 0.81
A Review of Radiotherapy-Induced Late Effects Research after Advanced Technology Treatments. Front Oncol (2016) 0.75
Does radiotherapy still have a role in unresected biliary tract cancer? Cancer Med (2016) 0.75
Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials. Clin Cancer Res (2016) 0.75
Improving radiotherapy in cancer treatment: Promises and challenges. Oncotarget (2017) 0.75
The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer (2012) 24.94
Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA (2010) 10.97
Inflammatory blockade restores adult hippocampal neurogenesis. Science (2003) 10.14
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med (1999) 9.16
Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med (2012) 8.46
Colorectal cancer. Lancet (2010) 8.36
Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (2003) 7.86
Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med (1999) 7.56
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature (2015) 7.49
Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med (1992) 7.40
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature (2005) 7.18
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science (1999) 6.97
An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol (2003) 6.82
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Nat Rev Cancer (2011) 6.44
DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol (2007) 5.78
Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol (2008) 5.10
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science (2008) 4.89
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med (2006) 4.84
A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N Engl J Med (1990) 4.66
Multi-institutional phase I/II trial of stereotactic body radiation therapy for liver metastases. J Clin Oncol (2009) 4.59
Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res (2009) 4.58
Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol (2003) 4.53
Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol (2014) 4.37
Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res (2005) 4.23
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science (1992) 4.04
Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res (2003) 3.81
Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res (2004) 3.53
Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol (2000) 3.24
Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst (2013) 3.07
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol Cancer Ther (2008) 3.07
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest (2014) 3.06
Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience (2003) 2.91
New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res (2010) 2.82
Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS One (2008) 2.70
Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: preliminary results of a phase III trial in regionally advanced, unresectable non-small-cell lung cancer. J Natl Cancer Inst (1995) 2.64
Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol (2008) 2.61
Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes. Cancer Res (2004) 2.54
Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy. J Immunol (2003) 2.51
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J Cell Biol (2010) 2.43
Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology (2003) 2.40
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res (2010) 2.34
The abscopal effect associated with a systemic anti-melanoma immune response. Int J Radiat Oncol Biol Phys (2012) 2.29
The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved? Int J Radiat Oncol Biol Phys (2014) 2.28
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (2009) 2.11
Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest (1994) 2.01
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell (2010) 1.94
Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity. J Immunol (2008) 1.93
Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection. Nature (2013) 1.91
Neuropsychological effects of cranial radiation: current knowledge and future directions. Int J Radiat Oncol Biol Phys (1995) 1.81
X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience (2000) 1.80
Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol (1996) 1.70
DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture. Mol Cancer Res (2008) 1.69
Phase 1 study of stereotactic body radiotherapy and interleukin-2--tumor and immunological responses. Sci Transl Med (2012) 1.61
Dose-escalation study of single-fraction stereotactic body radiotherapy for liver malignancies. Int J Radiat Oncol Biol Phys (2010) 1.60
DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy. Clin Cancer Res (2008) 1.59
MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Clin Cancer Res (2011) 1.59
PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Sci Transl Med (2014) 1.59
Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. Mol Cancer Ther (2011) 1.57
Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response. Clin Cancer Res (2014) 1.53
Stereotactic ablative radiotherapy for pulmonary oligometastases and oligometastatic lung cancer. J Thorac Oncol (2014) 1.51
Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing. J Immunol (2013) 1.44
Abscopal effect in a patient with melanoma. N Engl J Med (2012) 1.39
Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation. Cancer Res (1999) 1.39
Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination. Oncogene (2012) 1.31
Radiotherapy and radiosurgery for metastatic spine disease: what are the options, indications, and outcomes? Spine (Phila Pa 1976) (2009) 1.31
Macrophages from irradiated tumors express higher levels of iNOS, arginase-I and COX-2, and promote tumor growth. Int J Radiat Oncol Biol Phys (2007) 1.28
Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome. Breast Cancer Res Treat (2009) 1.27
Wee1 kinase as a target for cancer therapy. Cell Cycle (2013) 1.22
Emergence of stereotactic body radiation therapy and its impact on current and future clinical practice. J Clin Oncol (2014) 1.21
Radiation as an immune modulator. Semin Radiat Oncol (2013) 1.19
The role of local therapy in the management of lung and liver oligometastases. Nat Rev Clin Oncol (2011) 1.17
Targeting Wee1 for the treatment of pediatric high-grade gliomas. Neuro Oncol (2013) 1.15
Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes. J Biol Chem (2000) 1.14
Increase of NKG2D ligands and sensitivity to NK cell-mediated cytotoxicity of tumor cells by heat shock and ionizing radiation. Exp Mol Med (2006) 1.12
Irradiation promotes an m2 macrophage phenotype in tumor hypoxia. Front Oncol (2012) 1.12
Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia. Expert Opin Ther Pat (2010) 1.11
Secondary radiation damage as the main cause for unexpected volume effects: a histopathologic study of the parotid gland. Int J Radiat Oncol Biol Phys (2005) 1.09
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys (2012) 1.08
Radical irradiation of extracranial oligometastases. J Clin Oncol (2014) 1.07
Selective vulnerability to radiation in the hippocampal dentate granule cells. Surg Neurol (2000) 1.06
Bringing the heavy: carbon ion therapy in the radiobiological and clinical context. Radiat Oncol (2014) 1.03
Neurotrophic factor GDNF promotes survival of salivary stem cells. J Clin Invest (2014) 1.01
gamma-ray irradiation induces B7.1 expression in myeloid leukaemic cells. Br J Haematol (2000) 1.00
Improving the efficacy of chemoradiation with targeted agents. Cancer Discov (2014) 0.97
Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer. Clin Cancer Res (2014) 0.96
Molecular radiobiology: the state of the art. J Clin Oncol (2014) 0.96
A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Clin Cancer Res (2011) 0.96
Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776. Clin Cancer Res (2013) 0.95
Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors. Int J Radiat Oncol Biol Phys (2011) 0.93
Stem cell therapies for the treatment of radiation-induced normal tissue side effects. Antioxid Redox Signal (2014) 0.90
Current ideas to reduce or salvage radiation damage to salivary glands. Oral Dis (2014) 0.88
Sub-lethal irradiation of human colorectal tumor cells imparts enhanced and sustained susceptibility to multiple death receptor signaling pathways. PLoS One (2012) 0.86
WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas. Mol Cancer Ther (2012) 0.86
Promise and pitfalls of heavy-particle therapy. J Clin Oncol (2014) 0.85
CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells. Lung Cancer (2013) 0.84
Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. J Biomol Screen (2014) 0.83
Fractionated external beam radiotherapy as a suitable preparative regimen for hepatocyte transplantation after partial hepatectomy. Int J Radiat Oncol Biol Phys (2011) 0.80
Neural stem cell sparing by linac based intensity modulated stereotactic radiotherapy in intracranial tumors. Radiat Oncol (2013) 0.79
A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth. Clin Cancer Res (2013) 0.79
Lumbosacral spine and marrow cavity modeling of acute hematologic toxicity in patients treated with intensity modulated radiation therapy for squamous cell carcinoma of the anal canal. Pract Radiat Oncol (2013) 0.86
Predictors of toxicity associated with stereotactic body radiation therapy to the central hepatobiliary tract. Int J Radiat Oncol Biol Phys (2015) 0.82
Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther (2016) 0.75
Rectal and bladder deformation and displacement during preoperative radiotherapy for rectal cancer: Are current margin guidelines adequate for conformal therapy? Pract Radiat Oncol (2011) 0.75
Serum Transforming Growth Factor-β1 Change After Neoadjuvant Chemoradiation Therapy Is Associated With Postoperative Pulmonary Complications in Esophageal Cancer Patients Undergoing Combined Modality Therapy. Int J Radiat Oncol Biol Phys (2015) 0.75