Published in Metallomics on July 01, 2015
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol (2014) 2.73
Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci (2008) 2.49
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet (2003) 2.41
In situ imaging of metals in cells and tissues. Chem Rev (2009) 2.03
Cellular responses to Cisplatin-induced DNA damage. J Nucleic Acids (2010) 1.82
Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity. Neurobiol Dis (2003) 1.69
Immunohistochemistry. WormBook (2006) 1.48
A novel mode of ecdysozoan growth in Caenorhabditis elegans. Evol Dev (2002) 1.35
C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency. Genome Res (2014) 1.21
Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Mass Spectrom Rev (2009) 1.13
Neurotoxicity caused by the treatment with platinum analogues. Chemother Res Pract (2011) 1.12
Cisplatin resistance associated with PARP hyperactivation. Cancer Res (2013) 1.11
PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells. Carcinogenesis (2012) 1.11
The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy. Ther Adv Med Oncol (2011) 1.06
Regulation of chromatin structure by poly(ADP-ribosyl)ation. Front Genet (2012) 1.03
Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells. Biochem Pharmacol (2001) 1.00
Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies. Electrolyte Blood Press (2014) 0.97
Cerebral bioimaging of Cu, Fe, Zn, and Mn in the MPTP mouse model of Parkinson's disease using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). J Am Soc Mass Spectrom (2009) 0.96
A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. PLoS Genet (2012) 0.93
Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese. PLoS One (2012) 0.93
Molecular mass spectrometry imaging in biomedical and life science research. Histochem Cell Biol (2010) 0.91
Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Nucleic Acids Res (2011) 0.90
Metal-induced neurodegeneration in C. elegans. Front Aging Neurosci (2013) 0.89
The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. Biochem J (2002) 0.88
Nucleotide Excision Repair in Caenorhabditis elegans. Mol Biol Int (2011) 0.87
Elemental bioimaging in kidney by LA-ICP-MS as a tool to study nephrotoxicity and renal protective strategies in cisplatin therapies. Anal Chem (2011) 0.87
Dopaminergic neurotoxicity of S-ethyl N,N-dipropylthiocarbamate (EPTC), molinate, and S-methyl-N,N-diethylthiocarbamate (MeDETC) in Caenorhabditis elegans. J Neurochem (2013) 0.86
Imaging of metals in biological tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS): state of the art and future developments. J Mass Spectrom (2013) 0.85
Extravasation of Pt-based chemotherapeutics - bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). Metallomics (2015) 0.85
Quantitative bioimaging of platinum in polymer embedded mouse organs using laser ablation ICP-MS. Metallomics (2013) 0.85
ASNA-1 activity modulates sensitivity to cisplatin. Cancer Res (2010) 0.84
Elemental imaging of MRI contrast agents: benchmarking of LA-ICP-MS to MRI. Anal Bioanal Chem (2012) 0.83
Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease. Neurochem Int (2007) 0.83
Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice. Metallomics (2014) 0.80
Laser ablation ICP-MS for quantitative biomedical applications. Anal Bioanal Chem (2012) 0.80
Complementarity of MALDI and LA ICP mass spectrometry for platinum anticancer imaging in human tumor. Metallomics (2014) 0.79
The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies. Expert Opin Drug Metab Toxicol (2008) 0.79
Elemental bioimaging of manganese uptake in C. elegans. Metallomics (2014) 0.78
Depletion of the ER chaperone ENPL-1 sensitizes C. elegans to the anticancer drug cisplatin. Worm (2013) 0.78
Laser ablation based bioimaging with simultaneous elemental and molecular mass spectrometry: towards spatially resolved speciation analysis. Rapid Commun Mass Spectrom (2013) 0.78
Ionizing radiations in Caenorhabditis elegans induce poly(ADP-ribosyl)ation, a conserved DNA-damage response essential for survival. DNA Repair (Amst) (2005) 0.78
Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response. Mol Nutr Food Res (2013) 0.77
Total reflection X-ray fluorescence spectrometry as a tool for the quantification of gold and platinum metallodrugs: determination of recovery rates and precision in the ppb concentration range. J Pharm Biomed Anal (2012) 0.76
Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications. Anal Bioanal Chem (2012) 0.76
Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci (2008) 2.49
Manganese neurotoxicity may underlie the association between early life iron deficiency and impaired spatial cognition in neonatal piglets. J Nutr (2013) 2.16
Nutritional aspects of manganese homeostasis. Mol Aspects Med (2005) 2.03
Manganese neurotoxicity. Ann N Y Acad Sci (2004) 1.94
Role of manganese in neurodegenerative diseases. J Trace Elem Med Biol (2011) 1.73
Mefloquine neurotoxicity is mediated by non-receptor tyrosine kinase. Neurotoxicology (2011) 1.56
Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol Appl Pharmacol (2003) 1.55
Manganese transport in eukaryotes: the role of DMT1. Neurotoxicology (2008) 1.53
Autocrine purinergic receptor signaling is essential for macrophage chemotaxis. Sci Signal (2010) 1.52
The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain. Toxicology (2011) 1.51
Speciation analysis of gadolinium chelates in hospital effluents and wastewater treatment plant sewage by a novel HILIC/ICP-MS method. Environ Sci Technol (2009) 1.44
Developmental neuropathology of environmental agents. Annu Rev Pharmacol Toxicol (2004) 1.28
Oxidative stress in MeHg-induced neurotoxicity. Toxicol Appl Pharmacol (2011) 1.28
Anticholinesterase toxicity and oxidative stress. ScientificWorldJournal (2006) 1.27
Manganese neurotoxicity: a focus on the neonate. Pharmacol Ther (2006) 1.26
Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity. Neurotoxicology (2006) 1.25
Extracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans. PLoS Genet (2010) 1.23
Oxidative damage and neurodegeneration in manganese-induced neurotoxicity. Toxicol Appl Pharmacol (2009) 1.23
Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations. Biol Trace Elem Res (2002) 1.23
Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation. J Neurochem (2009) 1.23
Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegeneration. Environ Toxicol Pharmacol (2005) 1.22
Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene. Neurotoxicology (2007) 1.22
Manganese neurotoxicity and glutamate-GABA interaction. Neurochem Int (2003) 1.20
Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes. Neurotoxicology (2006) 1.20
Manganese induces oxidative impairment in cultured rat astrocytes. Toxicol Sci (2007) 1.20
Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders. Occup Environ Med (2012) 1.17
Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci (2011) 1.16
In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese. Environ Health Perspect (2010) 1.16
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. Neurotoxicology (2008) 1.15
Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity. Exp Neurol (2007) 1.15
The chloroplast calcium sensor CAS is required for photoacclimation in Chlamydomonas reinhardtii. Plant Cell (2011) 1.15
Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications. Toxicol Lett (2002) 1.12
SyM-BBB: a microfluidic Blood Brain Barrier model. Lab Chip (2013) 1.12
Co(II) and Cd(II) substitute for Zn(II) in the zinc finger derived from the DNA repair protein XPA, demonstrating a variety of potential mechanisms of toxicity. Chem Res Toxicol (2004) 1.12
SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans. PLoS One (2009) 1.11
Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain. Toxicol Sci (2006) 1.11
Roles of glutamine in neurotransmission. Neuron Glia Biol (2011) 1.11
Manganese exposure among smelting workers: blood manganese-iron ratio as a novel tool for manganese exposure assessment. Biomarkers (2009) 1.11
Recent developments in optical detection methods for microchip separations. Anal Bioanal Chem (2006) 1.11
Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency. J Nutr Biochem (2004) 1.09
Manganese exposure and induced oxidative stress in the rat brain. Sci Total Environ (2004) 1.08
Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells. DNA Repair (Amst) (2006) 1.08
Manganese-induced cytotoxicity in dopamine-producing cells. Neurotoxicology (2004) 1.08
Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain. Toxicol Appl Pharmacol (2007) 1.07
Pathophysiology of manganese-associated neurotoxicity. Neurotoxicology (2011) 1.06
Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. J Neurochem (2009) 1.06
Role of astrocytes in brain function and disease. Toxicol Pathol (2010) 1.06
A manganese-enhanced diet alters brain metals and transporters in the developing rat. Toxicol Sci (2006) 1.05
Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells. Toxicol Sci (2010) 1.05
Biomimetic modeling of oxidative drug metabolism : Strategies, advantages and limitations. Anal Bioanal Chem (2007) 1.05
The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation. Neurochem Int (2006) 1.05
Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes. J Neurochem (2009) 1.04
Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease. Chem Rev (2009) 1.04
Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function. Neurotoxicology (2008) 1.03
Determining the oxidation states of manganese in NT2 cells and cultured astrocytes. Neurobiol Aging (2005) 1.03
Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes. Brain Res (2006) 1.03
Manganese Is Essential for Neuronal Health. Annu Rev Nutr (2015) 1.03
Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes. Brain Res Mol Brain Res (2005) 1.03
Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging. Toxicol Sci (2008) 1.02
The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter. J Neurochem (2008) 1.02
Monomethylarsonous acid destroys a tetrathiolate zinc finger much more efficiently than inorganic arsenite: mechanistic considerations and consequences for DNA repair inhibition. Chem Res Toxicol (2008) 1.02
Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants. Brain Res Mol Brain Res (2003) 1.01
Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET. Toxicol Sci (2010) 1.00
Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes. Neurotoxicology (2002) 1.00
Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure. J Neurochem (2009) 1.00
Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures. Brain Res (2008) 0.99
Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochem Int (2012) 0.99
Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology (2005) 0.99
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity. Toxicol Sci (2007) 0.99
Estrogen and tamoxifen protect against Mn-induced toxicity in rat cortical primary cultures of neurons and astrocytes. Toxicol Sci (2009) 0.98
Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist. Toxicol Appl Pharmacol (2009) 0.98
Modulation of cholinergic systems by manganese. Neurotoxicology (2007) 0.98
Manganese (Mn) and iron (Fe): interdependency of transport and regulation. Neurotox Res (2009) 0.98
Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen. Neurotoxicology (2011) 0.98
Labeling strategies for bioassays. Anal Bioanal Chem (2005) 0.97
Measurement of isoprostanes as markers of oxidative stress in neuronal tissue. Curr Protoc Toxicol (2009) 0.97
Leaching of trace elements from biological tissue by formalin fixation. Biol Trace Elem Res (2007) 0.97
Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs. Cancer Chemother Pharmacol (2010) 0.97
Monitoring enzymatic conversions by mass spectrometry: a critical review. Anal Bioanal Chem (2005) 0.97
Mefloquine induces oxidative stress and neurodegeneration in primary rat cortical neurons. Neurotoxicology (2010) 0.96
GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes. J Biol Chem (2012) 0.96
Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury. Brain Res Mol Brain Res (2004) 0.96
Recent methods for the determination of peroxide-based explosives. Anal Bioanal Chem (2006) 0.96
Retracted Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null mice. Am J Physiol Heart Circ Physiol (2007) 0.96
Dynamic peptides as biomimetic carbohydrate receptors. Angew Chem Int Ed Engl (2010) 0.96
Neonatal rat primary microglia: isolation, culturing, and selected applications. Curr Protoc Toxicol (2010) 0.95
Characterization of the effects of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol (2009) 0.94
The importance of glutamate, glycine, and gamma-aminobutyric acid transport and regulation in manganese, mercury and lead neurotoxicity. Toxicol Appl Pharmacol (2005) 0.94
A chronic iron-deficient/high-manganese diet in rodents results in increased brain oxidative stress and behavioral deficits in the morris water maze. Neurotox Res (2009) 0.93
Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity. Glia (2011) 0.93
Transforming growth factor-α mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia (2012) 0.92
Role of astrocytes in manganese mediated neurotoxicity. BMC Pharmacol Toxicol (2013) 0.92
Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism. PLoS One (2012) 0.92
trans-10,cis-12-Conjugated linoleic acid instigates inflammation in human adipocytes compared with preadipocytes. J Biol Chem (2010) 0.92
Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice. Brain Res Bull (2008) 0.92
Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes. Toxicol Sci (2008) 0.92
Hormetic effect of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol (2010) 0.92
Changes in dietary iron exacerbate regional brain manganese accumulation as determined by magnetic resonance imaging. Toxicol Sci (2010) 0.92