Published in Acta Pharmacol Sin on May 25, 2015
Discovery of the First Environment-Sensitive Fluorescent Probe for GPR120 (FFA4) Imaging. ACS Med Chem Lett (2017) 0.75
Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40. Int J Mol Sci (2017) 0.75
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell (2010) 8.69
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci U S A (1997) 7.07
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature (2003) 6.87
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med (2004) 6.16
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem (2002) 4.11
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature (2012) 3.41
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol (2006) 2.62
Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J Clin Nutr (1975) 2.06
Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. Clin Ther (2007) 1.86
Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci (2011) 1.60
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev (2013) 1.60
Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett (2003) 1.59
The regulation of adipogenesis through GPR120. Biochem Biophys Res Commun (2007) 1.55
Free fatty acids induce cholecystokinin secretion through GPR120. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.52
Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol (2009) 1.38
Biochemistry and physiology of n-3 fatty acids. FASEB J (1992) 1.27
The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol (2013) 1.18
Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis. J Nutr (2005) 1.18
G protein-coupled receptors in human fat taste perception. Chem Senses (2011) 1.18
Discovery of a potent and selective GPR120 agonist. J Med Chem (2012) 1.16
Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs. Prog Lipid Res (2012) 1.13
Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol Pharmacol (2012) 1.13
Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists. J Med Chem (2008) 1.08
Distribution and regulation of protein expression of the free fatty acid receptor GPR120. Naunyn Schmiedebergs Arch Pharmacol (2009) 1.04
Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. Biochem Biophys Res Commun (2010) 1.02
Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma. Oncogene (2013) 0.99
An α-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-κB in rats with TNBS-induced colitis. J Nutr (2010) 0.97
Omega-3 ethylester concentrate: a review of its use in secondary prevention post-myocardial infarction and the treatment of hypertriglyceridaemia. Drugs (2009) 0.97
Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. Inflamm Bowel Dis (2008) 0.95
Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants. Comp Biochem Physiol B Biochem Mol Biol (2009) 0.95
Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells. Lipids Health Dis (2013) 0.93
Oxytocin-induced elevation of ADP-ribosyl cyclase activity, cyclic ADP-ribose or Ca(2+) concentrations is involved in autoregulation of oxytocin secretion in the hypothalamus and posterior pituitary in male mice. Neuropharmacology (2009) 0.85
Role of kidney ADP-ribosyl cyclase in diabetic nephropathy. Am J Physiol Renal Physiol (2008) 0.85
Sorafenib inhibits proliferation and invasion of human hepatocellular carcinoma cells via up-regulation of p53 and suppressing FoxM1. Acta Pharmacol Sin (2015) 0.83
Determinants of the membrane orientation of a calcium signaling enzyme CD38. Biochim Biophys Acta (2014) 0.82
Thromboxane-induced renal vasoconstriction is mediated by the ADP-ribosyl cyclase CD38 and superoxide anion. Am J Physiol Renal Physiol (2013) 0.81
Dietary α-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. Nutrition (2012) 0.81
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett (2014) 0.81
Action and Signaling of Lysophosphatidylethanolamine in MDA-MB-231 Breast Cancer Cells. Biomol Ther (Seoul) (2014) 0.80
OSU-CG5, a novel energy restriction mimetic agent, targets human colorectal cancer cells in vitro. Acta Pharmacol Sin (2014) 0.79
Dietary flaxseed intake exacerbates acute colonic mucosal injury and inflammation induced by dextran sodium sulfate. Am J Physiol Gastrointest Liver Physiol (2014) 0.79
GSK-3β suppresses the proliferation of rat hepatic oval cells through modulating Wnt/β-catenin signaling pathway. Acta Pharmacol Sin (2015) 0.78
Anti-allergic effect of α-cubebenoate isolated from Schisandra chinensis using in vivo and in vitro experiments. J Ethnopharmacol (2015) 0.81
Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity. J Ethnopharmacol (2015) 0.77
[Role of S1P in the lipoprotein-induced actions and their signaling mechanism]. Seikagaku (2009) 0.75