A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis.

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Published in Dis Model Mech on May 28, 2015

Authors

Xiaohua Xu1, Aleksandar Denic1, Luke R Jordan2, Nathan J Wittenberg3, Arthur E Warrington1, Bharath Wootla1, Louisa M Papke1, Laurie J Zoecklein1, Daehan Yoo3, Jonah Shaver3, Sang-Hyun Oh4, Larry R Pease5, Moses Rodriguez6

Author Affiliations

1: Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
2: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
3: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
4: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA sang@umn.edu rodriguez.moses@mayo.edu.
5: Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
6: Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA sang@umn.edu rodriguez.moses@mayo.edu.

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