From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMID 20348957)

Published in Nat Genet on March 28, 2010

Authors

John M Lincecum1, Fernando G Vieira, Monica Z Wang, Kenneth Thompson, Gerald S De Zutter, Joshua Kidd, Andrew Moreno, Ricardo Sanchez, Isarelis J Carrion, Beth A Levine, Bashar M Al-Nakhala, Shawn M Sullivan, Alan Gill, Steven Perrin

Author Affiliations

1: ALS Therapy Development Institute, Cambridge, Massachusetts, USA.

Articles citing this

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. Nat Rev Neurol (2011) 2.73

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest (2012) 2.67

A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep (2013) 1.92

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis. Brain (2011) 1.90

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival. EMBO Mol Med (2012) 1.42

TNF superfamily in inflammatory disease: translating basic insights. Trends Immunol (2011) 1.29

SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments. Mamm Genome (2011) 1.17

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann Neurol (2014) 1.12

New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal (2014) 1.06

The Role of immune and inflammatory mechanisms in ALS. Curr Mol Med (2011) 1.05

Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice. PLoS One (2011) 0.98

Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis. PLoS One (2011) 0.96

Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway. BMC Med Genomics (2011) 0.93

Peripheral nerve inflammation in ALS mice: cause or consequence. Neurology (2012) 0.85

The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease. Hum Mol Genet (2011) 0.84

Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis. Brain (2015) 0.83

Use of peripheral blood transcriptome biomarkers for epilepsy prediction. Neurosci Lett (2011) 0.83

EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS. PLoS One (2013) 0.82

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis. Dis Model Mech (2015) 0.82

NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress. Antioxid Redox Signal (2014) 0.81

Use of biomarkers in ALS drug development and clinical trials. Brain Res (2014) 0.79

Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis. Neurotherapeutics (2015) 0.79

Dexpramipexole is ineffective in two models of ALS related neurodegeneration. PLoS One (2014) 0.79

Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration. Hum Mol Genet (2014) 0.79

Designing phenotyping studies for genetically engineered mice. Vet Pathol (2011) 0.78

Amyotrophic lateral sclerosis: a focus on disease progression. Biomed Res Int (2014) 0.77

Interleukin-6 Deficiency Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutation. PLoS One (2016) 0.76

Regulatory role of cytosolic phospholipase A2 alpha in the induction of CD40 in microglia. J Neuroinflammation (2017) 0.75

Differentiated State of Initiating Tumor Cells Is Key to Distinctive Immune Responses Seen in H-Ras(G12V)-Induced Squamous Tumors. Cancer Immunol Res (2017) 0.75

Unraveling gene expression profiles in peripheral motor nerve from amyotrophic lateral sclerosis patients: insights into pathogenesis. Sci Rep (2016) 0.75

Design of Biomedical Robots for Phenotype Prediction Problems. J Comput Biol (2016) 0.75

ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity. JCI Insight (2017) 0.75

Articles cited by this

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science (1999) 83.27

Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov (2004) 15.57

Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics (2002) 12.88

A global test for groups of genes: testing association with a clinical outcome. Bioinformatics (2004) 10.82

Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer. J Clin Oncol (2006) 7.24

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci U S A (1990) 6.19

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci U S A (1992) 4.77

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2006) 4.52

Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science (1993) 4.45

Design, power, and interpretation of studies in the standard murine model of ALS. Amyotroph Lateral Scler (2008) 4.05

Retracted Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial. Lancet Oncol (2007) 3.67

Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science (1993) 3.30

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A (1997) 3.25

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proc Natl Acad Sci U S A (2008) 2.72

The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells. J Immunol (1993) 2.53

SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest (2008) 2.42

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci U S A (1996) 2.38

Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science (1996) 2.36

Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proc Natl Acad Sci U S A (2006) 2.08

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol (1992) 2.01

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nat Neurosci (2002) 1.97

CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation. Immunol Today (1992) 1.93

Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. Nat Med (2003) 1.92

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J Immunol (1995) 1.89

Sural nerve biopsies in Guillain-Barre syndrome: axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome. Muscle Nerve (1992) 1.67

Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice. PLoS One (2008) 1.65

CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation (1996) 1.63

Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. J Immunol (2000) 1.55

Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis. Arch Neurol (1993) 1.51

CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression. J Immunol (1999) 1.50

No benefit from chronic lithium dosing in a sibling-matched, gender balanced, investigator-blinded trial using a standard mouse model of familial ALS. PLoS One (2009) 1.23

Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses. J Immunol (1996) 1.21

Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol (1990) 1.20

Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis. Clin Neuropathol (1990) 1.16

Gene expression profiling of non-small-cell lung cancer. Expert Rev Mol Diagn (2008) 1.00

Genomic and proteomic profiling for biomarkers and signature profiles of toxicity. Curr Opin Mol Ther (2004) 0.99

Macrophage differentiation antigens in acute and chronic autoimmune polyneuropathies. Brain (1998) 0.93

Mechanisms of Disease: biomarkers and molecular targets from microarray gene expression studies in prostate cancer. Nat Clin Pract Urol (2007) 0.89

Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model. J Immunol (1997) 0.86

Long-term anti-CD154 dosing in nephritic mice is required to maintain survival and inhibit mediators of renal fibrosis. Lupus (2001) 0.86

FcR interactions do not play a major role in inhibition of experimental autoimmune encephalomyelitis by anti-CD154 monoclonal antibodies. J Immunol (2004) 0.83

RNA profiling of MS brain tissues. Int MS J (2008) 0.83

Toxicogenomics in biomarker discovery. Methods Mol Biol (2008) 0.77

Articles by these authors

Design, power, and interpretation of studies in the standard murine model of ALS. Amyotroph Lateral Scler (2008) 4.05

A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol (2006) 3.68

TWEAK induces liver progenitor cell proliferation. J Clin Invest (2005) 2.68

Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Clin Infect Dis (2008) 2.00

Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function. Immunity (2005) 1.94

The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E. Neuron (2004) 1.79

N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model. Bioconjug Chem (2006) 1.33

SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol (2008) 1.26

No benefit from chronic lithium dosing in a sibling-matched, gender balanced, investigator-blinded trial using a standard mouse model of familial ALS. PLoS One (2009) 1.23

Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration. J Neurosci (2004) 1.18

Emotional disclosure through patient narrative may improve pain and well-being: results of a randomized controlled trial in patients with cancer pain. J Pain Symptom Manage (2008) 1.14

A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation (2009) 1.12

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model. J Pharm Sci (2002) 1.10

Tweak induces mammary epithelial branching morphogenesis. Oncogene (2005) 1.02

Expression, purification, and characterization of rat interferon-beta, and preparation of an N-terminally PEGylated form with improved pharmacokinetic parameters. Protein Expr Purif (2004) 0.93

Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors. PLoS One (2011) 0.91

Frequency of human papillomavirus infection, coinfection, and association with different risk factors in Colombia. Ann Epidemiol (2011) 0.90

Initial adjustments within a new river channel: Interactions between fluvial processes, colonizing vegetation, and bank profile development. Environ Manage (2006) 0.87

Persistent inflammation and hyperresponsiveness following viral rhinosinusitis. Laryngoscope (2006) 0.87

Detection by PCR of human papillomavirus in Colombia: Comparison of GP5+/6+ and MY09/11 primer sets. J Virol Methods (2011) 0.87

Nondestructive quality control for microarray production. Biotechniques (2002) 0.85

The diagnostic performance of classical molecular tests used for detecting human papillomavirus. J Virol Methods (2012) 0.84

Classical molecular tests using urine samples as a potential screening tool for human papillomavirus detection in human immunodeficiency virus-infected women. J Clin Microbiol (2013) 0.84

Accurate and precise transcriptional profiles from 50 pg of total RNA or 100 flow-sorted primary lymphocytes. Genomics (2006) 0.84

Role of type 1 T helper cells in the resolution of acute Streptococcus pneumoniae sinusitis: a mouse model. J Infect Dis (2005) 0.83

Efficacy of two 65 % permethrin spot-on formulations against canine infestations of Ctenocephalides felis and Rhipicephalus sanguineus. Vet Ther (2002) 0.83

Identification of potent and novel alpha4beta1 antagonists using in silico screening. J Med Chem (2002) 0.82

Effect of genetic background on the response to bacterial sinusitis in mice. Arch Otolaryngol Head Neck Surg (2006) 0.82

Human papillomavirus detection from human immunodeficiency virus-infected Colombian women's paired urine and cervical samples. PLoS One (2013) 0.81

Impact of IL-1beta on flow-induced outward arterial remodeling. Surgery (2004) 0.80

Human papillomavirus detection in women with and without human immunodeficiency virus infection in Colombia. BMC Cancer (2014) 0.80

Expression of Sonic hedgehog-Fc fusion protein in Pichia pastoris. Identification and control of post-translational, chemical, and proteolytic modifications. Protein Expr Purif (2003) 0.80

Reduction of preoperative conjunctival bacterial flora with the use of mupirocin nasal ointment. Trans Am Ophthalmol Soc (2006) 0.80

Exercise self-efficacy, habitual physical activity, and fear of falling in patients with coronary heart disease. Cardiopulm Phys Ther J (2009) 0.79

Identification of FDA-approved drugs that computationally bind to MDM2. Chem Biol Drug Des (2012) 0.79

Mortality among critically ill patients with methicillin-resistant Staphylococcus aureus bacteremia: a multicenter cohort study in Colombia. Rev Panam Salud Publica (2012) 0.79

Evaluation of importance of Toll-like receptor 4 in acute Streptococcus pneumoniae sinusitis in mice. Arch Otolaryngol Head Neck Surg (2005) 0.78

Detection of lumbosacral nerve root compression with a novel composite nerve conduction measurement. Spine (Phila Pa 1976) (2002) 0.78

Antigen stimulation of TH2 cells augments acute bacterial sinusitis in mice. J Allergy Clin Immunol (2004) 0.77

Effect of montelukast on bacterial sinusitis in allergic mice. Ann Allergy Asthma Immunol (2006) 0.77

Application of functional genomic technologies in a mouse model of retinal degeneration. Genomics (2005) 0.77

The effect of treatment with moxifloxacin or azithromycin on acute bacterial rhinosinusitis in mice. Int J Infect Dis (2006) 0.76

Extraction and separation of urinary catecholamines as their diphenyl boronate complexes using C18 solid-phase extraction sorbent and high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 0.76

Norfloxacin treatment for clinically significant portal hypertension: results of a randomised double-blind placebo-controlled crossover trial. Liver Int (2008) 0.76

Pathologic quiz case: a 56-year-old woman with anterior nasal pain and intermittent epistaxis. Alternaria alternate infection of the nasal sinus. Arch Pathol Lab Med (2004) 0.75

Residue depletion study and withdrawal period for flunixin-N-methyl glucamine in bovine milk following intravenous administration. J Agric Food Chem (2003) 0.75

A non-variable L1-peptide displays high sensitivity and specificity for detecting women having human papillomavirus-associated cervical lesions. Peptides (2008) 0.75

Personal and societal benefits of providing peer support: a survey of peer support specialists. Psychiatr Serv (2014) 0.75

Effect of topical ciprofloxacin/dexamethasone or dexamethasone alone on acute Streptococcus pneumoniae rhinosinusitis in mice. Otolaryngol Head Neck Surg (2008) 0.75

Safety of novel oral anticoagulants in catheter ablation of atrial fibrillation. Dan Med J (2016) 0.75

Flunixin residues in milk after intravenous treatment of dairy cattle with (14)C-flunixin. J Agric Food Chem (2002) 0.75