Published in J Cell Sci on June 03, 2015
Mapping growth-factor-modulated Akt signaling dynamics. J Cell Sci (2016) 0.78
Unraveling Growth Factor Signaling and Cell Cycle Progression in Individual Fibroblasts. J Biol Chem (2016) 0.75
Quantification of Growth Factor Signaling and Pathway Crosstalk by Live-Cell Imaging. Am J Physiol Cell Physiol (2017) 0.75
Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev (2016) 0.75
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 32.32
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
Global quantification of mammalian gene expression control. Nature (2011) 22.36
Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature (1978) 11.49
Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science (2004) 8.44
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell (2006) 6.15
Production and purification of lentiviral vectors. Nat Protoc (2006) 6.01
Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem (1999) 5.66
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol (1997) 5.49
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell (2006) 5.36
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem (1999) 4.83
Methods for cell and particle tracking. Methods Enzymol (2012) 4.80
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J (2004) 3.92
Improving FRET dynamic range with bright green and red fluorescent proteins. Nat Methods (2012) 3.54
p53 dynamics control cell fate. Science (2012) 3.30
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin Ther Targets (2012) 2.55
The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell (2013) 2.37
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. Biochem J (2001) 2.36
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J Biol Chem (2002) 2.33
Development of an optimized backbone of FRET biosensors for kinases and GTPases. Mol Biol Cell (2011) 2.28
Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell (2013) 2.22
Tunable signal processing through modular control of transcription factor translocation. Science (2013) 2.11
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell (2012) 2.11
Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem (2004) 1.96
Insulin-like growth factor receptor inhibitors: baby or the bathwater? J Natl Cancer Inst (2012) 1.86
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO J (2002) 1.83
High-sensitivity measurements of multiple kinase activities in live single cells. Cell (2014) 1.76
IGF binding proteins in cancer: mechanistic and clinical insights. Nat Rev Cancer (2014) 1.75
Molecular imaging of Akt kinase activity. Nat Med (2007) 1.68
Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains. Mol Biol Cell (2008) 1.57
Interplay between FOXO, TOR, and Akt. Biochim Biophys Acta (2011) 1.47
Dynamic response diversity of NFAT isoforms in individual living cells. Mol Cell (2012) 1.28
Bone Morphogenetic Protein (BMP) signaling in development and human diseases. Genes Dis (2014) 1.27
Proteome-wide measurement of protein half-lives and translation rates in vasopressin-sensitive collecting duct cells. J Am Soc Nephrol (2013) 1.22
IGF-binding proteins--the pieces are falling into place. Trends Endocrinol Metab (2005) 1.22
Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation. Mol Biol Cell (2006) 1.15
Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation. Mol Cell Biol (2009) 1.12
Cellular dimensions affecting the nucleocytoplasmic volume ratio. J Cell Biol (1991) 1.04
Single-cell analysis of G-protein signal transduction. J Biol Chem (2015) 1.04
Insulin-like growth factor-binding protein-5 inhibits osteoblast differentiation and skeletal growth by blocking insulin-like growth factor actions. Mol Endocrinol (2008) 1.01
Achieving specificity in Akt signaling in cancer. Adv Biol Regul (2012) 0.97
The decline and fall of the IGF-I receptor. J Cell Physiol (2013) 0.95
The unique activity of bone morphogenetic proteins in bone: a critical role of the Smad signaling pathway. Biol Chem (2013) 0.90
Dynamic Visualization of mTORC1 Activity in Living Cells. Cell Rep (2015) 0.88
Signal transduction in cancer. Cold Spring Harb Perspect Med (2015) 0.88
Development of a FRET biosensor with high specificity for Akt. Cell Struct Funct (2013) 0.83
Mapping growth-factor-modulated Akt signaling dynamics. J Cell Sci (2016) 0.78