Published in Science on June 15, 2012
The role of senescent cells in ageing. Nature (2014) 3.03
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature (2014) 2.79
Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell (2013) 2.22
Tunable signal processing through modular control of transcription factor translocation. Science (2013) 2.11
Functional roles of pulsing in genetic circuits. Science (2013) 1.84
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science (2015) 1.83
LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Mol Cell (2014) 1.79
High-sensitivity measurements of multiple kinase activities in live single cells. Cell (2014) 1.76
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol (2013) 1.73
Coordination of bacterial proteome with metabolism by cyclic AMP signalling. Nature (2013) 1.70
Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science (2014) 1.64
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. Cell (2016) 1.55
Illuminating cell signalling with optogenetic tools. Nat Rev Mol Cell Biol (2014) 1.46
The dynamics of signaling as a pharmacological target. Cell (2013) 1.45
Another fork in the road--life or death decisions by the tumour suppressor p53. EMBO Rep (2013) 1.43
A novel mathematical model of ATM/p53/NF- κB pathways points to the importance of the DDR switch-off mechanisms. BMC Syst Biol (2016) 1.41
p53 is renoprotective after ischemic kidney injury by reducing inflammation. J Am Soc Nephrol (2012) 1.37
Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expression. Mol Syst Biol (2013) 1.31
Push back to respond better: regulatory inhibition of the DNA double-strand break response. Nat Rev Mol Cell Biol (2013) 1.29
Rate of environmental change determines stress response specificity. Proc Natl Acad Sci U S A (2013) 1.21
Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep (2014) 1.21
p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage. Cell Res (2015) 1.11
Stem cells: balancing resistance and sensitivity to DNA damage. Trends Cell Biol (2014) 1.09
The dynamic control of signal transduction networks in cancer cells. Nat Rev Cancer (2015) 1.09
Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells. Nat Commun (2014) 1.07
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control. BMC Biol (2013) 1.06
Ionizing radiation-induced responses in human cells with differing TP53 status. Int J Mol Sci (2013) 1.04
Direct observation of frequency modulated transcription in single cells using light activation. Elife (2013) 1.03
LOC401317, a p53-regulated long non-coding RNA, inhibits cell proliferation and induces apoptosis in the nasopharyngeal carcinoma cell line HNE2. PLoS One (2014) 1.02
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol (2013) 1.02
Start and the restriction point. Curr Opin Cell Biol (2013) 1.01
The regulation of MDM2 oncogene and its impact on human cancers. Acta Biochim Biophys Sin (Shanghai) (2014) 0.97
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis. Transl Cancer Res (2013) 0.96
Tumor suppressor p53 plays a key role in induction of both tristetraprolin and let-7 in human cancer cells. Nucleic Acids Res (2013) 0.95
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle (2015) 0.95
Beyond generalized hair cells: molecular cues for hair cell types. Hear Res (2012) 0.94
The yeast environmental stress response regulates mutagenesis induced by proteotoxic stress. PLoS Genet (2013) 0.94
The Growing Complexity of Cancer Cell Response to DNA-Damaging Agents: Caspase 3 Mediates Cell Death or Survival? Int J Mol Sci (2016) 0.94
Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions. Development (2014) 0.92
Mechanisms that enhance sustainability of p53 pulses. PLoS One (2013) 0.91
Surviving apoptosis: life-death signaling in single cells. Trends Cell Biol (2015) 0.90
Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM-induced autophagy or BAX. Liver Int (2013) 0.90
Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells. J Bone Miner Metab (2014) 0.89
The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development. Biomaterials (2014) 0.89
Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity. Protein Cell (2014) 0.88
Cell-to-cell variability in cell death: can systems biology help us make sense of it all? Cell Death Dis (2014) 0.87
Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit. Cell Rep (2016) 0.87
TIGAR regulates glycolysis in ischemic kidney proximal tubules. Am J Physiol Renal Physiol (2014) 0.86
Recent discoveries in the cycling, growing and aging of the p53 field. Aging (Albany NY) (2012) 0.85
Schedule-dependent interaction between anticancer treatments. Science (2016) 0.85
Pulsatile dynamics in the yeast proteome. Curr Biol (2014) 0.85
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity. Mol Biol Cell (2012) 0.85
Modeling the epigenetic attractors landscape: toward a post-genomic mechanistic understanding of development. Front Genet (2015) 0.84
Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun (2015) 0.84
A General Network Pharmacodynamic Model-Based Design Pipeline for Customized Cancer Therapy Applied to the VEGFR Pathway. CPT Pharmacometrics Syst Pharmacol (2014) 0.84
Single-cell variation leads to population invariance in NF-κB signaling dynamics. Mol Biol Cell (2014) 0.84
Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. Oncotarget (2014) 0.84
Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development. Biol Open (2015) 0.83
DDX3, a potential target for cancer treatment. Mol Cancer (2015) 0.83
Sources of dynamic variability in NF-κB signal transduction: a mechanistic model. Bioessays (2015) 0.83
Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. Nat Commun (2014) 0.83
Modelling the onset of senescence at the G1/S cell cycle checkpoint. BMC Genomics (2014) 0.83
Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage. Toxicol Sci (2014) 0.83
DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Nat Commun (2017) 0.83
Regulation of DNA damage responses and cell cycle progression by hMOB2. Cell Signal (2014) 0.82
Nested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks. J R Soc Interface (2013) 0.82
Network biology concepts in complex disease comorbidities. Nat Rev Genet (2016) 0.82
Optogenetic control of nuclear protein export. Nat Commun (2016) 0.82
How to understand and outwit adaptation. Dev Cell (2014) 0.82
MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast. Sci Signal (2015) 0.82
NF-κB oscillations translate into functionally related patterns of gene expression. Elife (2016) 0.82
Digital signaling decouples activation probability and population heterogeneity. Elife (2015) 0.82
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget (2012) 0.82
A novel ATM/TP53/p21-mediated checkpoint only activated by chronic γ-irradiation. PLoS One (2014) 0.82
p53 Pulses Diversify Target Gene Expression Dynamics in an mRNA Half-Life-Dependent Manner and Delineate Co-regulated Target Gene Subnetworks. Cell Syst (2016) 0.82
Tight control of hypoxia-inducible factor-α transient dynamics is essential for cell survival in hypoxia. J Biol Chem (2014) 0.81
Akt signaling dynamics in individual cells. J Cell Sci (2015) 0.81
Accurate encoding and decoding by single cells: amplitude versus frequency modulation. PLoS Comput Biol (2015) 0.81
Digital microfluidic immunocytochemistry in single cells. Nat Commun (2015) 0.80
Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells. Apoptosis (2014) 0.80
Circuit-level input integration in bacterial gene regulation. Proc Natl Acad Sci U S A (2013) 0.80
Redefining Signaling Pathways with an Expanding Single-Cell Toolbox. Trends Biotechnol (2016) 0.80
Inferring Cell-State Transition Dynamics from Lineage Trees and Endpoint Single-Cell Measurements. Cell Syst (2016) 0.80
Visualizing and manipulating temporal signaling dynamics with fluorescence-based tools. Sci Signal (2014) 0.80
Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2. Proc Natl Acad Sci U S A (2016) 0.80
The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation. PLoS One (2013) 0.79
Acting on impulse: dissecting the dynamics of the NFAT transcriptional response. Genome Biol (2013) 0.79
Constant rate of p53 tetramerization in response to DNA damage controls the p53 response. Mol Syst Biol (2014) 0.79
Nanoscale label-free bioprobes to detect intracellular proteins in single living cells. Sci Rep (2014) 0.79
A protein turnover signaling motif controls the stimulus-sensitivity of stress response pathways. PLoS Comput Biol (2013) 0.79
Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition. Cell (2015) 0.79
Dynamic single cell measurements of kinase activity by synthetic kinase activity relocation sensors. BMC Biol (2015) 0.79
MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells. PLoS Comput Biol (2015) 0.79
Bystander communication and cell cycle decisions after DNA damage. Front Genet (2015) 0.78
Computational analysis of signaling patterns in single cells. Semin Cell Dev Biol (2014) 0.78
Dynamics of posttranslational modifications of p53. Comput Math Methods Med (2014) 0.78
A checklist for successful quantitative live cell imaging in systems biology. Cells (2013) 0.78
Mapping growth-factor-modulated Akt signaling dynamics. J Cell Sci (2016) 0.78
Dynamic reprogramming of chromatin: paradigmatic palimpsests and HES factors. Front Genet (2015) 0.78
Surfing the p53 network. Nature (2000) 35.36
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42
Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Stochastic mRNA synthesis in mammalian cells. PLoS Biol (2006) 12.58
Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol (2008) 11.05
Imaging individual mRNA molecules using multiple singly labeled probes. Nat Methods (2008) 10.40
Calcium oscillations increase the efficiency and specificity of gene expression. Nature (1998) 9.19
Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science (2004) 8.44
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30
Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer (2004) 6.67
Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol (2002) 6.05
An excitable gene regulatory circuit induces transient cellular differentiation. Nature (2006) 6.03
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27
Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science (2005) 5.14
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev (2000) 5.04
The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae. Science (2008) 4.94
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol (2007) 4.75
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A (2006) 4.68
Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer (2008) 4.63
Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature (2008) 4.63
Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59
Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science (2009) 4.14
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Coping with stress: multiple ways to activate p53. Oncogene (2007) 3.57
Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell (2006) 3.32
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 2.70
PML is a direct p53 target that modulates p53 effector functions. Mol Cell (2004) 2.40
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40
Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell (2008) 2.00
A noisy paracrine signal determines the cellular NF-kappaB response to lipopolysaccharide. Sci Signal (2009) 1.91
Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles. PLoS One (2009) 1.81
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res (2007) 1.67
Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging. Cancer Res (2006) 1.34
YPEL3, a p53-regulated gene that induces cellular senescence. Cancer Res (2010) 0.96
Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54
Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat Methods (2006) 2.94
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 2.70
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40
The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13
Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95
Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol Cell (2012) 1.91
High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis. Cell Stem Cell (2013) 1.86
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell (2011) 1.53
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature (2013) 1.50
Distinct mechanisms act in concert to mediate cell cycle arrest. Proc Natl Acad Sci U S A (2009) 1.37
Fourier analysis and systems identification of the p53 feedback loop. Proc Natl Acad Sci U S A (2010) 1.19
Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J (2004) 1.18
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells. Curr Opin Genet Dev (2011) 1.18
Activation and control of p53 tetramerization in individual living cells. Proc Natl Acad Sci U S A (2013) 1.12
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol (2013) 1.02
A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A (2010) 0.92
Differential protein occupancy profiling of the mRNA transcriptome. Genome Biol (2014) 0.92
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol Cell Biol (2010) 0.83
Dynamics of the DNA damage response: insights from live-cell imaging. Brief Funct Genomics (2013) 0.82
Decoding the insulin signal. Mol Cell (2012) 0.82
Cellular conference call: external feedback affects cell-fate decisions. Cell (2006) 0.79
Signal transduction and signaling networks. Mol Biol Cell (2013) 0.77
Suppressing variation in synthetic circuits. Mol Syst Biol (2011) 0.76
Promoter decoding of transcription factor dynamics. Mol Syst Biol (2013) 0.75
Using computational modeling and experimental synthetic perturbations to probe biological circuits. Methods Mol Biol (2015) 0.75