Published in Cell on February 28, 2013
Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell (2013) 2.22
Functional roles of pulsing in genetic circuits. Science (2013) 1.84
Secreting and sensing the same molecule allows cells to achieve versatile social behaviors. Science (2014) 1.80
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol (2013) 1.73
Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network. Science (2015) 1.58
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. Cell (2016) 1.55
Combinatorial gene regulation by modulation of relative pulse timing. Nature (2015) 1.51
Illuminating cell signalling with optogenetic tools. Nat Rev Mol Cell Biol (2014) 1.46
The dynamics of signaling as a pharmacological target. Cell (2013) 1.45
Optical control of cell signaling by single-chain photoswitchable kinases. Science (2017) 1.41
Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. Genes Dev (2017) 1.38
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Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expression. Mol Syst Biol (2013) 1.31
T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo. Immunity (2014) 1.28
Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair. Immunity (2015) 1.26
Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics. Science (2014) 1.21
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Frequency modulation of ERK activation dynamics rewires cell fate. Mol Syst Biol (2015) 1.11
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Reciprocal encoding of signal intensity and duration in a glucose-sensing circuit. Cell (2014) 1.01
Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes. Sci Signal (2014) 0.99
Tunable signal processing through a kinase control cycle: the IKK signaling node. Biophys J (2013) 0.94
Limits on information transduction through amplitude and frequency regulation of transcription factor activity. Elife (2015) 0.93
Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions. Development (2014) 0.92
Regulation of transcriptional bursting by a naturally oscillating signal. Curr Biol (2014) 0.90
Network dynamics determine the autocrine and paracrine signaling functions of TNF. Genes Dev (2014) 0.90
Applications of targeted proteomics in systems biology and translational medicine. Proteomics (2015) 0.90
High-throughput microfluidics to control and measure signaling dynamics in single yeast cells. Nat Protoc (2015) 0.88
Exclusive photorelease of signalling lipids at the plasma membrane. Nat Commun (2015) 0.88
Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity. Protein Cell (2014) 0.88
Cell-to-cell variability in cell death: can systems biology help us make sense of it all? Cell Death Dis (2014) 0.87
High-throughput analysis of NF-κB dynamics in single cells reveals basal nuclear localization of NF-κB and spontaneous activation of oscillations. PLoS One (2014) 0.87
Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts. Nat Protoc (2013) 0.87
Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses. J Biol Chem (2015) 0.86
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Translatome analyses capture of opposing tissue-specific brassinosteroid signals orchestrating root meristem differentiation. Proc Natl Acad Sci U S A (2015) 0.85
Optogenetic Control of Calcium Oscillation Waveform Defines NFAT as an Integrator of Calcium Load. Cell Syst (2016) 0.84
Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis. Genes Dev (2016) 0.84
Disentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes. Adv Biol Regul (2013) 0.84
Cellular noise suppression by the regulator of G protein signaling Sst2. Mol Cell (2014) 0.84
Sources of dynamic variability in NF-κB signal transduction: a mechanistic model. Bioessays (2015) 0.83
Elements of the cellular metabolic structure. Front Mol Biosci (2015) 0.83
Auxin-induced degradation dynamics set the pace for lateral root development. Development (2015) 0.83
Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. Nat Commun (2014) 0.83
Deciphering deterioration mechanisms of complex diseases based on the construction of dynamic networks and systems analysis. Sci Rep (2015) 0.83
Spatial and temporal organization of signaling pathways. Trends Biochem Sci (2014) 0.83
DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Nat Commun (2017) 0.83
Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses. Sci Signal (2016) 0.82
MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast. Sci Signal (2015) 0.82
NF-κB oscillations translate into functionally related patterns of gene expression. Elife (2016) 0.82
Akt signaling dynamics in individual cells. J Cell Sci (2015) 0.81
The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium. Nat Commun (2015) 0.81
Ubiquitin-Dependent Regulation of Stem Cell Biology. Trends Cell Biol (2017) 0.81
How to train your microbe: methods for dynamically characterizing gene networks. Curr Opin Microbiol (2015) 0.81
Noise and low-level dynamics can coordinate multicomponent bet hedging mechanisms. Biophys J (2015) 0.80
Digital microfluidic immunocytochemistry in single cells. Nat Commun (2015) 0.80
Visualizing and manipulating temporal signaling dynamics with fluorescence-based tools. Sci Signal (2014) 0.80
Cellular Levels of Signaling Factors Are Sensed by β-actin Alleles to Modulate Transcriptional Pulse Intensity. Cell Rep (2015) 0.80
Diffusion Tensor Analysis by Two-Dimensional Pair Correlation of Fluorescence Fluctuations in Cells. Biophys J (2016) 0.80
Dynamic information routing in complex networks. Nat Commun (2016) 0.80
Interlocked positive and negative feedback network motifs regulate β-catenin activity in the adherens junction pathway. Mol Biol Cell (2015) 0.80
Single-cell analysis of circadian dynamics in tissue explants. Mol Biol Cell (2015) 0.79
Pulsatile hormonal signaling to extracellular signal-regulated kinase: exploring system sensitivity to gonadotropin-releasing hormone pulse frequency and width. J Biol Chem (2014) 0.79
Mimicking subsecond neurotransmitter dynamics with femtosecond laser stimulated nanosystems. Sci Rep (2014) 0.79
Negative interactions and feedback regulations are required for transient cellular response. Sci Rep (2014) 0.78
Deceivingly dynamic: Learning-dependent changes in stathmin and microtubules. Neurobiol Learn Mem (2015) 0.78
Computational analysis of signaling patterns in single cells. Semin Cell Dev Biol (2014) 0.78
Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma. Cell Commun Signal (2015) 0.78
Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells. Stem Cells Int (2015) 0.78
Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways. Sci Signal (2016) 0.78
Identifying causal networks linking cancer processes and anti-tumor immunity using Bayesian network inference and metagene constructs. Biotechnol Prog (2016) 0.78
Quantitative analysis of receptor tyrosine kinase-effector coupling at functionally relevant stimulus levels. J Biol Chem (2015) 0.77
Eavesdropping on altered cell-to-cell signaling in cancer by secretome profiling. Mol Cell Oncol (2015) 0.77
Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study. J Immunother Cancer (2015) 0.77
Communication shapes sensory response in multicellular networks. Proc Natl Acad Sci U S A (2016) 0.77
SUMO as a nuclear hormone receptor effector: New insights into combinatorial transcriptional regulation. Worm (2014) 0.77
Spatial and temporal signal processing and decision making by MAPK pathways. J Cell Biol (2017) 0.76
Towards programming immune tolerance through geometric manipulation of phosphatidylserine. Biomaterials (2015) 0.76
Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation. Integr Biol (Camb) (2015) 0.76
Tracing anti-cancer and cancer-promoting actions of all-trans retinoic acid in breast cancer to a RARα epigenetic mechanism of mammary epithelial cell fate. Oncotarget (2016) 0.76
Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling. PLoS Comput Biol (2016) 0.76
Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking. Nat Struct Mol Biol (2016) 0.76
Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. Sci Rep (2015) 0.76
Hierarchical feedback modules and reaction hubs in cell signaling networks. PLoS One (2015) 0.76
Single-Cell and Single-Molecule Analysis of Gene Expression Regulation. Annu Rev Genet (2016) 0.76
Processing Oscillatory Signals by Incoherent Feedforward Loops. PLoS Comput Biol (2016) 0.76
Extracellular matrix stiffness modulates VEGF calcium signaling in endothelial cells: individual cell and population analysis. Integr Biol (Camb) (2015) 0.76
The dynamic mechanism of noisy signal decoding in gene regulation. Sci Rep (2017) 0.75
A Regulated Double-Negative Feedback Decodes the Temporal Gradient of Input Stimulation in a Cell Signaling Network. PLoS One (2016) 0.75
Evolving modular genetic regulatory networks with a recursive, top-down approach. Syst Synth Biol (2015) 0.75
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Laguerre Filter Analysis with Partial Least Square Regression Reveals a Priming Effect of ERK and CREB on c-FOS Induction. PLoS One (2016) 0.75
Single Cell Proteolytic Assays to Investigate Cancer Clonal Heterogeneity and Cell Dynamics Using an Efficient Cell Loading Scheme. Sci Rep (2016) 0.75
High-throughput single-cell analysis for the proteomic dynamics study of the yeast osmotic stress response. Sci Rep (2017) 0.75
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Interpreting frequency responses to dose-conserved pulsatile input signals in simple cell signaling motifs. PLoS One (2014) 0.75
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