Genome-wide single-nucleotide polymorphism analysis revealed SUFU suppression of acute graft-versus-host disease through downregulation of HLA-DR expression in recipient dendritic cells.

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Published in Sci Rep on June 11, 2015

Authors

Rafijul Bari1, Christine Hartford1, Wing Keung Chan1, Queenie Vong1, Ying Li1, Kwan Gan1, Yinmei Zhou2, Cheng Cheng2, Guolian Kang2, Sheila Shurtleff3, Victoria Turner3, Ching-Hon Pui4, James R Downing3, Wing Leung5

Author Affiliations

1: Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.
2: Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.
3: Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.
4: 1] Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN [2] Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN [3] Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
5: 1] Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN [2] Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Associated clinical trials:

Therapy for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia | NCT00137111

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