Development of gene and stem cell therapy for ocular neurodegeneration.

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51

Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med (2008) 17.21

Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med (2008) 15.30

Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell (2009) 11.65

Phototransduction by retinal ganglion cells that set the circadian clock. Science (2002) 10.42

Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science (2002) 9.08

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell (2008) 7.79

Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet (2012) 7.70

Retinal repair by transplantation of photoreceptor precursors. Nature (2006) 6.73

Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature (2011) 6.51

Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet (2000) 4.42

Restoration of vision after transplantation of photoreceptors. Nature (2012) 3.91

Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell (2012) 3.85

Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Arch Ophthalmol (2011) 3.79

Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem Cell (2009) 3.66

Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci U S A (2006) 3.49

Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells. Cell Stem Cell (2009) 3.09

Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement. Proc Natl Acad Sci U S A (2013) 2.71

Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells. Stem Cells (2009) 2.70

Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration. Stem Cells (2009) 2.56

Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. PLoS One (2009) 2.54

Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A (2011) 2.39

Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proc Natl Acad Sci U S A (2002) 2.34

Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. Cloning Stem Cells (2004) 2.32

Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis. Mol Ther (2005) 2.27

Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats. Cloning Stem Cells (2006) 2.23

Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract. Nat Genet (2002) 2.21

Functional and structural recovery of the retina after gene therapy in the RPE65 null mutation dog. Invest Ophthalmol Vis Sci (2003) 2.18

Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. Invest Ophthalmol Vis Sci (2004) 2.10

Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Mol Cell Neurosci (2000) 2.07

Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation. Exp Neurol (2008) 2.03

Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy. Gene Ther (2008) 2.00

Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. Proc Natl Acad Sci U S A (2008) 1.89

Stepwise differentiation of pluripotent stem cells into retinal cells. Nat Protoc (2009) 1.88

Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs. Am J Hum Genet (2009) 1.73

A comprehensive review of retinal gene therapy. Mol Ther (2013) 1.70

Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res (2002) 1.56

Development of human embryonic stem cell therapies for age-related macular degeneration. Trends Neurosci (2013) 1.51

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nat Genet (2012) 1.51

Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration. Proc Natl Acad Sci U S A (2011) 1.47

Autologous transplantation of the retinal pigment epithelium and choroid in the treatment of neovascular age-related macular degeneration. Ophthalmology (2007) 1.44

Comprehensive survey of mutations in RP2 and RPGR in patients affected with distinct retinal dystrophies: genotype-phenotype correlations and impact on genetic counseling. Hum Mutat (2007) 1.44

Restoration of visual response in aged dystrophic RCS rats using AAV-mediated channelopsin-2 gene transfer. Invest Ophthalmol Vis Sci (2007) 1.41

Aflibercept treatment for patients with exudative age-related macular degeneration who were incomplete responders to multiple ranibizumab injections (TURF trial). Br J Ophthalmol (2014) 1.41

Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of leber hereditary optic neuropathy in Chinese families with the m.11778G-->a mutation. Am J Hum Genet (2008) 1.29

Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population. Mol Vis (2009) 1.28

Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium. Stem Cells Transl Med (2013) 1.27

Lentiviral gene replacement therapy of retinas in a mouse model for Usher syndrome type 1B. Gene Ther (2007) 1.23

Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys. Mol Ther (2005) 1.19

Photoreceptor differentiation and integration of retinal progenitor cells transplanted into transgenic rats. Exp Eye Res (2005) 1.14

Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes. Invest Ophthalmol Vis Sci (2011) 1.06

Generation of retinal ganglion-like cells from reprogrammed mouse fibroblasts. Invest Ophthalmol Vis Sci (2010) 1.05

Evaluation of AAV-mediated expression of Chop2-GFP in the marmoset retina. Invest Ophthalmol Vis Sci (2010) 1.05

Mechanisms of apoptosis in retinitis pigmentosa. Curr Mol Med (2009) 1.00

Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry (2008) 0.98

In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors. Biochem Biophys Res Commun (2009) 0.97

Effect of anti-VEGF antibody on retinal ganglion cells in rats. Br J Ophthalmol (2007) 0.96

Transplantation of adult rat hippocampus-derived neural stem cells into retina injured by transient ischemia. Neurosci Lett (2001) 0.92

Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates. Gene Ther (2011) 0.91

Aflibercept (VEGF Trap-Eye) for the treatment of exudative age-related macular degeneration. Expert Rev Clin Pharmacol (2013) 0.89

Transplantation of tissue-engineered retinal pigment epithelial cell sheets in a rabbit model. Biomaterials (2008) 0.86

Long-term outcomes following full macular translocation surgery in neovascular age-related macular degeneration. Br J Ophthalmol (2010) 0.83

On the role of CNTF as a potential therapy for retinal degeneration: Dr. Jekyll or Mr. Hyde? Adv Exp Med Biol (2008) 0.81

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. 1989. Biochem Biophys Res Commun (2012) 0.80

Protection of retinal ganglion cells against glaucomatous neuropathy by neurotrophin-producing, genetically modified neural progenitor cells in a rat model. Chin Med J (Engl) (2002) 0.76

[Progress in gene studies of hereditary retinal diseases]. Zhonghua Yan Ke Za Zhi (2010) 0.76