Published in Mol Biol Cell on July 01, 2015
Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks. Neoplasia (2015) 0.79
Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases. J Biol Chem (2016) 0.78
Recent advances in understanding nuclear size and shape. Nucleus (2016) 0.76
Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence. BMC Genomics (2016) 0.75
Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells. Immune Netw (2016) 0.75
Suberoylanilide hydroxamic acid represses glioma stem-like cells. J Biomed Sci (2016) 0.75
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007) 16.95
The selectivity of protein kinase inhibitors: a further update. Biochem J (2007) 15.73
The hallmarks of aging. Cell (2013) 14.29
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
Senescence of activated stellate cells limits liver fibrosis. Cell (2008) 8.98
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol (2003) 8.32
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell (2008) 7.65
The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature (2005) 6.86
Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell (2002) 6.76
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature (2011) 6.14
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63
Aging, cellular senescence, and cancer. Annu Rev Physiol (2012) 5.08
Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer (2009) 5.02
Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev (2007) 4.96
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83
Replicative senescence: the human fibroblast comes of age. Science (1990) 4.77
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell (2006) 4.74
Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74
Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol Biol Cell (2001) 3.59
Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol (2011) 3.40
PML is induced by oncogenic ras and promotes premature senescence. Genes Dev (2000) 3.35
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol (2010) 3.29
DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res (2002) 3.22
Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer (2004) 3.19
Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell (2014) 3.15
Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis (2004) 3.07
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol (2012) 2.99
Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol (2003) 2.96
Aurora kinases as anticancer drug targets. Clin Cancer Res (2008) 2.92
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. Nat Genet (2000) 2.87
Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene (2004) 2.81
Programmed cell senescence during mammalian embryonic development. Cell (2013) 2.78
The causes and consequences of polyploidy in normal development and cancer. Annu Rev Cell Dev Biol (2011) 2.54
Therapy-induced senescence in cancer. J Natl Cancer Inst (2010) 2.45
Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell (2010) 2.45
The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev (2011) 2.38
How do anti-mitotic drugs kill cancer cells? J Cell Sci (2009) 2.38
Cellular senescence and its effector programs. Genes Dev (2014) 2.37
Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a "tetraploidy checkpoint". J Cell Biol (2004) 2.34
Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell (2013) 2.33
The consequences of tetraploidy and aneuploidy. J Cell Sci (2008) 2.31
Validating Aurora B as an anti-cancer drug target. J Cell Sci (2006) 2.30
AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res (2007) 2.16
p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell (2012) 2.04
Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell (2012) 2.03
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell (2012) 2.02
G1 tetraploidy checkpoint and the suppression of tumorigenesis. J Cell Biochem (2003) 2.01
Inside and out: the activities of senescence in cancer. Nat Rev Cancer (2014) 1.96
Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc Natl Acad Sci U S A (2001) 1.96
Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol (2008) 1.89
Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view. Curr Opin Cell Biol (2009) 1.83
p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene (2000) 1.82
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev (2013) 1.78
Cell fusion induced by ERVWE1 or measles virus causes cellular senescence. Genes Dev (2013) 1.77
Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure. BMC Cell Biol (2005) 1.75
Replicative senescence of human fibroblast-like cells in culture. Physiol Rev (1993) 1.71
Loss of linker histone H1 in cellular senescence. J Cell Biol (2006) 1.71
The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function. Cancer Res (2006) 1.69
Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A (2012) 1.66
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature (2013) 1.66
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling. Genes Dev (2002) 1.65
Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation. EMBO J (2012) 1.60
Deconstructing PML-induced premature senescence. EMBO J (2002) 1.56
Necessary and sufficient role for a mitosis skip in senescence induction. Mol Cell (2014) 1.31
Lamin B1 fluctuations have differential effects on cellular proliferation and senescence. J Cell Biol (2013) 1.28
GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models. Mol Cancer Ther (2009) 1.27
Binding of latent and high Mr active forms of stromelysin to collagen is mediated by the C-terminal domain. J Cell Sci (1991) 1.26
Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins. J Cell Sci (2006) 1.25
Senescence: a new weapon for cancer therapy. Trends Cell Biol (2012) 1.25
Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev (2013) 1.23
The aurora kinases in cell cycle and leukemia. Oncogene (2014) 1.20
Update on Aurora Kinase Targeted Therapeutics in Oncology. Expert Opin Drug Discov (2011) 1.19
Increased nuclear sizes in senescent human diploid fibroblast cultures. Exp Cell Res (1976) 1.17
Mitotic drivers--inhibitors of the Aurora B Kinase. Cancer Metastasis Rev (2009) 1.14
MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo. Mol Cancer Res (2010) 1.11
Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence. EMBO Mol Med (2012) 1.10
Human papillomavirus oncoprotein E7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the Rb and p53 tumor suppressor pathways. Mol Cell Biol (2005) 1.08
Determinants for the efficiency of anticancer drugs targeting either Aurora-A or Aurora-B kinases in human colon carcinoma cells. Mol Cancer Ther (2009) 1.06
Senescent human diploid cells in culture: survival, DNA synthesis and morphology. J Gerontol (1979) 1.05
DNA damage associated with mitosis and cytokinesis failure. Oncogene (2013) 1.04
Transient activation of p53 in G2 phase is sufficient to induce senescence. Mol Cell (2014) 1.04
Cellular senescence bypass screen identifies new putative tumor suppressor genes. Oncogene (2007) 1.03
Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy. Int J Cancer (2002) 0.99
Hepatocytes polyploidization and cell cycle control in liver physiopathology. Int J Hepatol (2012) 0.91
A high-throughput method to identify novel senescence-inducing compounds. J Biomol Screen (2009) 0.90
Cancer cell senescence: a new frontier in drug development. Drug Discov Today (2012) 0.90
Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling. Mol Cancer Res (2008) 0.87
p31comet Induces cellular senescence through p21 accumulation and Mad2 disruption. Mol Cancer Res (2009) 0.87
Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? Longev Healthspan (2014) 0.87
Failure of cell cleavage induces senescence in tetraploid primary cells. Mol Biol Cell (2014) 0.86
A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle (2013) 0.85
Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway. FEBS Lett (2011) 0.85
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell (2006) 4.74
PML is a direct p53 target that modulates p53 effector functions. Mol Cell (2004) 2.40
Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell (2012) 2.02
The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. Genes Dev (2005) 1.70
Role of the chromobox protein CBX7 in lymphomagenesis. Proc Natl Acad Sci U S A (2007) 1.65
Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev (2013) 1.23
p400 is required for E1A to promote apoptosis. J Biol Chem (2005) 1.19
Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc. Proc Natl Acad Sci U S A (2008) 0.99
Spatio-temporal association between mTOR and autophagy during cellular senescence. Autophagy (2011) 0.86
The tumor suppressor ING1 contributes to epigenetic control of cellular senescence. Aging Cell (2010) 0.86
Cell senescence as both a dynamic and a static phenotype. Methods Mol Biol (2013) 0.82
Cultivated grapevines represent a symptomless reservoir for the transmission of hop stunt viroid to hop crops: 15 years of evolutionary analysis. PLoS One (2009) 0.80
Carotid atherosclerosis as a risk factor for complex aortic lesions in patients with ischemic cerebrovascular disease. Circ J (2003) 0.78