Published in Nature on October 13, 2005
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DNA breaks and chromosome pulverization from errors in mitosis. Nature (2012) 5.19
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Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One (2009) 3.36
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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature (2008) 2.95
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science (2017) 2.72
Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell (2010) 2.45
Molecular control of animal cell cytokinesis. Nat Cell Biol (2012) 2.45
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol (2010) 2.33
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. Cancer Cell (2012) 2.21
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Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol (2007) 1.77
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APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J Cell Biol (2007) 1.60
Oncogenic activities of human papillomaviruses. Virus Res (2009) 1.60
Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell (2007) 1.59
The Vif and Vpr accessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrest. Proc Natl Acad Sci U S A (2006) 1.58
Illicit survival of cancer cells during polyploidization and depolyploidization. Cell Death Differ (2010) 1.57
Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission. J Cell Biol (2010) 1.55
Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC. Nat Rev Cancer (2006) 1.53
Cell fusion as a hidden force in tumor progression. Cancer Res (2009) 1.51
Chromosomal instability and aneuploidy in cancer: from yeast to man. EMBO Rep (2012) 1.51
Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. J Exp Med (2007) 1.49
S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase. Cell (2013) 1.49
Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Nature (2012) 1.48
Linking abnormal mitosis to the acquisition of DNA damage. J Cell Biol (2012) 1.48
Cell Fusion Connects Oncogenesis with Tumor Evolution. Am J Pathol (2015) 1.44
When 2+2=5: the origins and fates of aneuploid and tetraploid cells. Biochim Biophys Acta (2008) 1.42
Ingression Progression Complexes Control Extracellular Matrix Remodelling during Cytokinesis in Budding Yeast. PLoS Genet (2016) 1.41
Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer. Proc Natl Acad Sci U S A (2008) 1.40
Plk4 is required for cytokinesis and maintenance of chromosomal stability. Proc Natl Acad Sci U S A (2010) 1.40
Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. Dev Cell (2016) 1.39
Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation. PLoS One (2015) 1.38
Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. J Clin Invest (2010) 1.38
Citron kinase controls abscission through RhoA and anillin. Mol Biol Cell (2011) 1.37
The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents. J Clin Invest (2009) 1.36
Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. J Clin Invest (2008) 1.29
Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect. Cancer Res (2008) 1.29
Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Am J Pathol (2007) 1.28
Mechanisms for concentrating Rho1 during cytokinesis. Genes Dev (2009) 1.28
Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. Mol Biol Cell (2006) 1.26
Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. Nucleic Acids Res (2006) 1.26
Causes and consequences of centrosome abnormalities in cancer. Philos Trans R Soc Lond B Biol Sci (2014) 1.26
pRB, a tumor suppressor with a stabilizing presence. Trends Cell Biol (2011) 1.25
p53: guardian of ploidy. Mol Oncol (2011) 1.25
Deregulated Aurora-B induced tetraploidy promotes tumorigenesis. FASEB J (2009) 1.23
Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway. PLoS One (2007) 1.23
RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure. Mol Cell Biol (2006) 1.23
SEPT9 occupies the terminal positions in septin octamers and mediates polymerization-dependent functions in abscission. J Cell Biol (2011) 1.22
The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis. Proc Natl Acad Sci U S A (2009) 1.22
Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention. Proc Natl Acad Sci U S A (2014) 1.22
The aurora kinases in cell cycle and leukemia. Oncogene (2014) 1.20
Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells. Cell Cycle (2012) 1.20
Transient nutlin-3a treatment promotes endoreduplication and the generation of therapy-resistant tetraploid cells. Cancer Res (2008) 1.18
Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell (2013) 1.17
Surveillance mechanism linking Bub1 loss to the p53 pathway. Proc Natl Acad Sci U S A (2007) 1.17
Furrow constriction in animal cell cytokinesis. Biophys J (2014) 1.15
Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement. Genome Res (2008) 1.15
A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells. PLoS One (2008) 1.14
TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18. Mol Cell Biol (2009) 1.14
Differential regulation of centrosome integrity by DNA damage response proteins. Cell Cycle (2008) 1.14
Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis. Mol Cell Biol (2009) 1.11
The requirement of p53 for maintaining chromosomal stability during tetraploidization. Oncotarget (2010) 1.11
Stem cells, senescence, neosis and self-renewal in cancer. Cancer Cell Int (2006) 1.11
DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. PLoS One (2010) 1.10
Enlazin, a natural fusion of two classes of canonical cytoskeletal proteins, contributes to cytokinesis dynamics. Mol Biol Cell (2006) 1.10
Making the cut: the chemical biology of cytokinesis. ACS Chem Biol (2010) 1.09
Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells. PLoS Genet (2012) 1.09
The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis. Front Cell Dev Biol (2015) 1.08
The PIDDosome activates p53 in response to supernumerary centrosomes. Genes Dev (2017) 1.07
Understanding cytokinesis failure. Adv Exp Med Biol (2010) 1.06
SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis. Oncogene (2011) 1.06
Dividing the spoils of growth and the cell cycle: The fission yeast as a model for the study of cytokinesis. Cytoskeleton (Hoboken) (2011) 1.05
p53 suppresses structural chromosome instability after mitotic arrest in human cells. Oncogene (2010) 1.05
DNA damage associated with mitosis and cytokinesis failure. Oncogene (2013) 1.04
Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell (2005) 15.06
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87
A mechanism linking extra centrosomes to chromosomal instability. Nature (2009) 9.45
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell (2004) 8.48
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell (2004) 8.16
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell (2003) 5.68
Cyclin E ablation in the mouse. Cell (2003) 5.58
Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain. Neuron (2009) 5.50
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell (2006) 5.34
DNA breaks and chromosome pulverization from errors in mitosis. Nature (2012) 5.19
Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev (2007) 4.96
Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell (2011) 4.78
From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol (2004) 4.72
Mouse development and cell proliferation in the absence of D-cyclins. Cell (2004) 4.69
An actin nucleation mechanism mediated by Bni1 and profilin. Nat Cell Biol (2002) 4.52
Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell (2010) 4.37
Causes and consequences of aneuploidy in cancer. Nat Rev Genet (2012) 4.08
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci U S A (2009) 4.02
Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol (2004) 3.99
p63 protects the female germ line during meiotic arrest. Nature (2006) 3.98
A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96
Yeast formins regulate cell polarity by controlling the assembly of actin cables. Nat Cell Biol (2002) 3.81
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev (2008) 3.79
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature (2003) 3.77
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell (2007) 3.76
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med (2004) 3.55
Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture. Cell (2004) 3.51
Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res (2004) 3.43
Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle. Nat Cell Biol (2006) 3.39
Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat Cell Biol (2002) 3.34
The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature (2002) 3.30
Suppression of lung adenocarcinoma progression by Nkx2-1. Nature (2011) 3.27
Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19
Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity (2003) 3.17
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med (2010) 3.09
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06
Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J Biol Chem (2003) 2.89
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature (2005) 2.87
Genome-wide genetic analysis of polyploidy in yeast. Nature (2006) 2.85
A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin. Mol Biol Cell (2003) 2.77
New Alström syndrome phenotypes based on the evaluation of 182 cases. Arch Intern Med (2005) 2.74
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell (2010) 2.68
Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci (2003) 2.67
Surfing on microtubule ends. Trends Cell Biol (2003) 2.61
Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation. Dev Cell (2004) 2.60
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
Determinants of S. cerevisiae dynein localization and activation: implications for the mechanism of spindle positioning. Curr Biol (2003) 2.56
Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A (2002) 2.54
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood (2007) 2.51
mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A (2008) 2.50
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell (2002) 2.48
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors. Cancer Discov (2012) 2.47
Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. Cancer Res (2007) 2.45
Development of mice expressing a single D-type cyclin. Genes Dev (2002) 2.43
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The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins. J Cell Biol (2003) 2.39
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med (2011) 2.35
Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency. Hum Mol Genet (2004) 2.32
Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet (2002) 2.30
Nuclear factor I/B is an oncogene in small cell lung cancer. Genes Dev (2011) 2.29
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol (2010) 2.26
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. Proc Natl Acad Sci U S A (2010) 2.20
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A (2007) 2.18
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proc Natl Acad Sci U S A (2006) 2.17
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell (2011) 2.17
Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development (2004) 2.14
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A (2004) 2.12
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A (2009) 2.11
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (2009) 2.11
A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma. Blood (2010) 2.08
Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint. Cancer Res (2004) 2.03
Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron (2007) 2.01
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc Natl Acad Sci U S A (2002) 1.99
Atlantic meridional overturning circulation during the Last Glacial Maximum. Science (2007) 1.98
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev (2010) 1.95
APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A (2002) 1.89
ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev (2013) 1.87
Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet (2006) 1.86
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev (2007) 1.81
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci (2006) 1.80
Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res (2008) 1.75
Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target. Cancer Cell (2009) 1.73
Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science (2006) 1.73
Limiting the proliferation of polyploid cells. Cell (2007) 1.72
Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev (2003) 1.70
Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J Biol Chem (2005) 1.67
Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma. Blood (2010) 1.66
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J (2002) 1.64
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol Cell Biol (2009) 1.63
Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. Genes Dev (2013) 1.61
Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A (2011) 1.58
A little CIN may cost a lot: revisiting aneuploidy and cancer. Curr Opin Genet Dev (2009) 1.57
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci U S A (2009) 1.56
Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Proc Natl Acad Sci U S A (2004) 1.55
Elucidating distinct roles for NF1 in melanomagenesis. Cancer Discov (2012) 1.53