Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells.

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Published in Bioorg Med Chem Lett on June 26, 2015

Authors

Jing Ma1, Chaemin Lim2, Joshua R Sacher3, Bennett Van Houten4, Wei Qian5, Peter Wipf6

Author Affiliations

1: Department of Pharmacology and Chemical Biology, University of Pittsburgh, and Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, United States; Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College of HuaZhong University of Science and Technology, Wuhan 430030, China.
2: Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, United States; Accelerated Chemical Discovery Center, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, United States.
3: Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, United States.
4: Department of Pharmacology and Chemical Biology, University of Pittsburgh, and Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, United States.
5: Department of Pharmacology and Chemical Biology, University of Pittsburgh, and Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, United States. Electronic address: qianw@upmc.edu.
6: Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, United States; Accelerated Chemical Discovery Center, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, United States. Electronic address: pwipf@pitt.edu.

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