Mitochondrial reactive oxygen species and cancer.

The Emerging Hallmarks of Cancer Metabolism. Cell Metab (2016) 2.32

Mitochondria and Cancer. Mol Cell (2016) 1.11

Calcium and ROS: A mutual interplay. Redox Biol (2015) 1.05

Mitochondria and Cancer. Cell (2016) 1.02

ROS homeostasis and metabolism: a dangerous liason in cancer cells. Cell Death Dis (2016) 0.94

The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α. EMBO Mol Med (2016) 0.85

Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab (2015) 0.84

Oxidative stress and the unfulfilled promises of antioxidant agents. Ecancermedicalscience (2015) 0.81

A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors. Clin Transl Med (2016) 0.81

Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy. Oncotarget (2016) 0.81

Altered metabolite levels in cancer: implications for tumour biology and cancer therapy. Nat Rev Cancer (2016) 0.80

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes Dev (2015) 0.80

Smart Radiation Therapy Biomaterials. Int J Radiat Oncol Biol Phys (2016) 0.79

Mitochondrial Ca(2+) Remodeling is a Prime Factor in Oncogenic Behavior. Front Oncol (2015) 0.78

Putative anticancer potential of novel 4-thiazolidinone derivatives: cytotoxicity toward rat C6 glioma in vitro and correlation of general toxicity with the balance of free radical oxidation in rats. Croat Med J (2016) 0.78

Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters. Proc Natl Acad Sci U S A (2016) 0.78

Covalent targeting of acquired cysteines in cancer. Curr Opin Chem Biol (2015) 0.78

Linkage of E2F1 transcriptional network and cell proliferation with respiratory chain activity in breast cancer cells. Cancer Sci (2016) 0.77

Role of mitochondrial dysfunction in cancer progression. Exp Biol Med (Maywood) (2016) 0.77

Mitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation Products. Antioxidants (Basel) (2016) 0.77

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev (2017) 0.76

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation. Mol Cancer (2017) 0.76

Effects of aging on the male reproductive system. J Assist Reprod Genet (2016) 0.76

Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer. Oncogenesis (2016) 0.76

A potential role of X-linked inhibitor of apoptosis protein in mitochondrial membrane permeabilization and its implication in cancer therapy. Drug Discov Today (2015) 0.76

Mitochondrial ROS control of cancer. Semin Cancer Biol (2017) 0.75

Melatonin, mitochondria, and the cancer cell. Cell Mol Life Sci (2017) 0.75

Inhibition of cancer antioxidant defense by natural compounds. Oncotarget (2016) 0.75

The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells. Front Oncol (2017) 0.75

The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity. Cancer Metab (2017) 0.75

SH003 induces apoptosis of DU145 prostate cancer cells by inhibiting ERK-involved pathway. BMC Complement Altern Med (2016) 0.75

Cytoprotective effect of rhamnetin on miconazole-induced H9c2 cell damage. Nutr Res Pract (2015) 0.75

RUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana. Sci Rep (2017) 0.75

TLR4/ROS/miRNA-21 pathway underlies lipopolysaccharide instructed primary tumor outgrowth in lung cancer patients. Oncotarget (2016) 0.75

Autophagy-Dependent Secretion: Contribution to Tumor Progression. Front Oncol (2016) 0.75

News about VDAC1 in Hypoxia. Front Oncol (2016) 0.75

Combination therapy induces unfolded protein response and cytoskeletal rearrangement leading to mitochondrial apoptosis in prostate cancer. Mol Oncol (2016) 0.75

VDAC-Tubulin, an Anti-Warburg Pro-Oxidant Switch. Front Oncol (2017) 0.75

Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorg Med Chem Lett (2015) 0.75

The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas. Oncotarget (2016) 0.75

Sabotaging of the oxidative stress response by an oncogenic noncoding RNA. FASEB J (2016) 0.75

Insights into the Regulatory Role of Non-coding RNAs in Cancer Metabolism. Front Physiol (2016) 0.75

SIRT3: Oncogene and Tumor Suppressor in Cancer. Cancers (Basel) (2017) 0.75

Mitochondria and Iron: current questions. Expert Rev Hematol (2016) 0.75

Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells. Cell Metab (2017) 0.75

In vitro and in vivo anti-proliferative evaluation of bis(4'-(4-tolyl)-2,2':6',2″-terpyridine)copper(II) complex against Ehrlich ascites carcinoma tumors. J Biol Inorg Chem (2017) 0.75

Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism. J Biol Chem (2017) 0.75

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation. Int J Mol Sci (2017) 0.75

Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover. Oncogene (2017) 0.75

Alterations in the Reactive Oxygen Species in Peripheral Blood of Chronic Myeloid Leukaemia Patients from Northern India. J Clin Diagn Res (2017) 0.75

Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors. Cell Metab (2017) 0.75

The Concerted Action of Mitochondrial Dynamics and Positioning: New Characters in Cancer Onset and Progression. Front Oncol (2017) 0.75

Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death. ACS Chem Biol (2017) 0.75

Targeting HIF-1 for cancer therapy. Nat Rev Cancer (2003) 28.01

The phosphoinositide 3-kinase pathway. Science (2002) 24.72

Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell (2008) 13.49

Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A (1993) 13.27

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab (2006) 13.22

How mitochondria produce reactive oxygen species. Biochem J (2009) 13.03

Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2011) 11.02

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell (2006) 10.10

Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med (1996) 10.09

Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature (2008) 9.77

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature (2011) 9.70

Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci (2003) 8.84

Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science (1995) 8.17

Hypoxia-inducible factors in physiology and medicine. Cell (2012) 8.16

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A (2010) 8.12

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A (2002) 8.01

The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J (2000) 7.77

NADPH oxidase: an update. Blood (1999) 7.65

The antioxidant function of the p53 tumor suppressor. Nat Med (2005) 7.57

Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature (2011) 7.03

Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res (1991) 6.99

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol (2003) 6.91

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A (1998) 6.90

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem (2000) 6.86

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem (2000) 6.71

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science (1997) 6.50

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science (2011) 5.72

Oxidant signals and oxidative stress. Curr Opin Cell Biol (2003) 5.67

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab (2005) 5.61

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal (2009) 5.57

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science (2008) 5.54

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell (2002) 5.47

Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem (2002) 5.08

Physiological roles of mitochondrial reactive oxygen species. Mol Cell (2012) 5.05

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science (2002) 4.88

HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell (2007) 4.81

Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov (2013) 4.72

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature (2003) 4.60

Oxygen radicals and human disease. Ann Intern Med (1987) 4.57

Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation. J Biol Chem (1997) 4.51

Mitochondrial DNA mutations in human cancer. Oncogene (2006) 4.08

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity (2013) 4.08

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab (2005) 3.94

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell (2012) 3.90

Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling. Cell (2010) 3.82

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature (2003) 3.77

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell (2011) 3.71

Thiol chemistry and specificity in redox signaling. Free Radic Biol Med (2008) 3.68

Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem (2004) 3.59

Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J (2003) 3.58

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol (2007) 3.47

Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47

The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev (2013) 3.40

MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab (2009) 3.30

JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell (2004) 3.30

NRF2 and cancer: the good, the bad and the importance of context. Nat Rev Cancer (2012) 3.04

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell (2011) 3.00

The sites and topology of mitochondrial superoxide production. Exp Gerontol (2010) 2.91

Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis. PLoS One (2012) 2.84

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res (2010) 2.80

An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell (2011) 2.78

Regulation of ferroptotic cancer cell death by GPX4. Cell (2014) 2.78

Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol (2006) 2.68

NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair. Pharmacol Rev (2011) 2.53

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife (2014) 2.48

Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol (2007) 2.45

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell (2013) 2.38

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production. Oncogene (2011) 2.35

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature (2014) 2.27

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol (2009) 2.27

Antioxidants accelerate lung cancer progression in mice. Sci Transl Med (2014) 2.23

E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination. Mol Cell (2002) 2.20

Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms. FEBS Lett (1999) 2.09

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. Biochem J (2009) 1.94

Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene (2006) 1.94

Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Circ Res (2009) 1.92

Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. Proc Natl Acad Sci U S A (2009) 1.91

Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem (2005) 1.88

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression. Oncogene (2010) 1.88

Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness. Integr Cancer Ther (2004) 1.84

A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. Cancer Res (2005) 1.69

Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest (2009) 1.68

Spectrum of somatic mitochondrial mutations in five cancers. Proc Natl Acad Sci U S A (2012) 1.63

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation. J Biol Chem (2010) 1.60

The SirT3 divining rod points to oxidative stress. Mol Cell (2011) 1.58

A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet (2009) 1.56

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Mol Cell (2013) 1.54

Role of superoxide as a signaling molecule. News Physiol Sci (2004) 1.51

Regulation of protein tyrosine phosphatases by reversible oxidation. J Biochem (2011) 1.48

Sorting out functions of sirtuins in cancer. Oncogene (2013) 1.47

Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity. Cell Metab (2011) 1.45

Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells. FEBS J (2007) 1.39

Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress. J Biol Chem (2007) 1.38

A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha. FEBS Lett (2005) 1.36

Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34

A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation. Proc Natl Acad Sci U S A (2008) 1.33