Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia: a molecular docking study exploring possible neuroprotection.

PubWeight™: 0.80‹?›

🔗 View Article (PMC 4424748)

Published in Neural Regen Res on April 01, 2015

Authors

Anand Kumar Pandey1, Pallab Bhattacharya2, Swet Chand Shukla3, Sudip Paul4, Ranjana Patnaik1

Author Affiliations

1: School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, India.
2: School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, India ; Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
3: School of Biochemical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, India.
4: School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, India ; Department of Biomedical Engineering, North Eastern Hill University (NEHU), Shillong, India.

Articles cited by this

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81

Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke (1989) 21.77

Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J (1991) 8.29

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke (1987) 4.97

The matrix-degrading metalloproteinases. Bioessays (1992) 4.84

Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet (1993) 3.72

Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke (1998) 3.58

Molecular architecture of basement membranes. FASEB J (1990) 3.28

Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke (1998) 3.03

Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res (1998) 3.01

Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci U S A (1997) 2.49

Resveratrol, a natural red wine polyphenol, reduces ischemia-reperfusion-induced spinal cord injury. Ann Thorac Surg (2005) 2.15

Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J Cereb Blood Flow Metab (1996) 2.01

Molecular Recognition of Proteinminus signLigand Complexes: Applications to Drug Design. Chem Rev (1997) 2.01

Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res (2002) 1.95

Determination of nitrite/nitrate in human biological material by the simple Griess reaction. Clin Chim Acta (1998) 1.77

Differences in vulnerability to permanent focal cerebral ischemia among 3 common mouse strains. Stroke (2000) 1.77

Human endothelial gelatinases and angiogenesis. Int J Biochem Cell Biol (2001) 1.67

Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion. Brain Res (1999) 1.62

Wine as a biological fluid: history, production, and role in disease prevention. J Clin Lab Anal (1997) 1.48

Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab (2000) 1.47

Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells. Adv Dent Res (1998) 1.39

[Malondialdehyde (MDA) as a lipid peroxidation marker]. Wiad Lek (2004) 1.29

Distinct mechanisms regulate interstitial collagenase and 92-kDa gelatinase expression in human monocytic-like cells exposed to bacterial endotoxin. J Biol Chem (1993) 1.20

Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity. J Mol Biol (2007) 1.13

Neuroprotective effects of the polyphenolic antioxidant agent, Curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat. Pharmacol Biochem Behav (2010) 1.10

Ebselen: prospective therapy for cerebral ischaemia. Expert Opin Investig Drugs (2000) 1.04

Intravenous TAT-GDNF is protective after focal cerebral ischemia in mice. Stroke (2003) 1.04

Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis. Front Neurol (2012) 1.03

Resveratrol, a neuroprotective supplement for Alzheimer's disease. Curr Pharm Des (2012) 1.01

Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia. Life Sci (2001) 1.01

Transcriptional induction of collagenase-1 in differentiated monocyte-like (U937) cells is regulated by AP-1 and an upstream C/EBP-beta site. J Biol Chem (1997) 0.99

Neuroprotective properties of resveratrol in different neurodegenerative disorders. Biofactors (2010) 0.99

Docking studies of matrix metalloproteinase inhibitors: zinc parameter optimization to improve the binding free energy prediction. J Mol Graph Model (2003) 0.98

The role of the nitric oxide pathway in brain injury and its treatment--from bench to bedside. Exp Neurol (2014) 0.98

Increased expression of matrix metalloproteinase-9 in neutrophils in glycogen-induced peritoneal inflammation of guinea pigs. Inflamm Res (2000) 0.97

Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities. FASEB J (2009) 0.97

Microvascular basal lamina injury after experimental focal cerebral ischemia and reperfusion in the rat. J Cereb Blood Flow Metab (2002) 0.93

Differential alterations in the expression and activity of matrix metalloproteinases 2 and 9 after transient cerebral ischemia in mice. Neurobiol Dis (2004) 0.92

Transcriptional downregulation of stromelysin by tetracycline. J Cell Biochem (1996) 0.89

Peanut roots as a source of resveratrol. J Agric Food Chem (2002) 0.87

Retracted A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia. Eur J Neurosci (2013) 0.87

Homology modeling of gelatinase catalytic domains and docking simulations of novel sulfonamide inhibitors. J Med Chem (1999) 0.87

Inward remodeling of the rabbit aorta is blocked by the matrix metalloproteinase inhibitor doxycycline. J Vasc Res (2004) 0.86

Inhibitory effect of quercetin on matrix metalloproteinase 9 activity molecular mechanism and structure-activity relationship of the flavonoid-enzyme interaction. Eur J Pharmacol (2010) 0.82

An in-silico strategy to explore neuroprotection by quercetin in cerebral ischemia: a novel hypothesis based on inhibition of matrix metalloproteinase (MMPs) and acid sensing ion channel 1a (ASIC1a). Med Hypotheses (2012) 0.78