Published in Stroke on October 01, 1998
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A (1999) 3.96
Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience (2008) 2.55
Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci (2002) 2.21
Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. Neurobiol Dis (2010) 1.90
Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage. J Neurosci (2012) 1.89
Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure. Hepatology (2009) 1.87
The importance of early brain injury after subarachnoid hemorrhage. Prog Neurobiol (2012) 1.84
Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. BMC Neurosci (2006) 1.69
Neurological diseases in relation to the blood-brain barrier. J Cereb Blood Flow Metab (2012) 1.62
Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci (2006) 1.58
Peripheral markers of brain damage and blood-brain barrier dysfunction. Restor Neurol Neurosci (2003) 1.56
Blood-brain barrier disruption in humans is independently associated with increased matrix metalloproteinase-9. Stroke (2009) 1.56
Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia. J Neurochem (2009) 1.53
Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. J Virol (2008) 1.49
Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab (2013) 1.41
Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes. BMC Neurol (2007) 1.41
Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. J Neurosci (2012) 1.39
Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr Neuropharmacol (2008) 1.38
Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. Proc Natl Acad Sci U S A (2007) 1.35
Induction of mmp-9 expression and endothelial injury by oxidative stress after spinal cord injury. J Neurotrauma (2008) 1.35
Severe blood-brain barrier disruption and surrounding tissue injury. Stroke (2009) 1.33
Early beneficial effect of matrix metalloproteinase inhibition on blood-brain barrier permeability as measured by magnetic resonance imaging countered by impaired long-term recovery after stroke in rat brain. J Cereb Blood Flow Metab (2007) 1.30
Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. J Pharmacol Exp Ther (2007) 1.29
Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke (2009) 1.26
Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke. J Neurochem (2008) 1.24
Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke. Front Neurol (2013) 1.23
Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage. J Cereb Blood Flow Metab (2010) 1.19
Matrix metalloproteinases in the adult brain physiology: a link between c-Fos, AP-1 and remodeling of neuronal connections? EMBO J (2002) 1.15
Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption. J Cereb Blood Flow Metab (2007) 1.13
Borrelia spirochetes upregulate release and activation of matrix metalloproteinase gelatinase B (MMP-9) and collagenase 1 (MMP-1) in human cells. Infect Immun (2001) 1.13
Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases. Exp Neurol (2010) 1.13
Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS? Br J Pharmacol (2010) 1.12
Microglial cell activation is a source of metalloproteinase generation during hemorrhagic transformation. J Cereb Blood Flow Metab (2012) 1.10
Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol (2011) 1.10
Ultrastructural and temporal changes of the microvascular basement membrane and astrocyte interface following focal cerebral ischemia. J Neurosci Res (2009) 1.10
Antiinflammatory activity of melatonin in central nervous system. Curr Neuropharmacol (2010) 1.09
Aquaporin 4: a player in cerebral edema and neuroinflammation. J Neuroinflammation (2012) 1.09
Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date. Drug Des Devel Ther (2014) 1.09
Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway. J Neuroinflammation (2010) 1.09
Neurovascular injury in acute hyperglycemia and diabetes: A comparative analysis in experimental stroke. Transl Stroke Res (2011) 1.08
Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat. BMC Neurosci (2009) 1.06
Alteration of microvascular permeability in acute kidney injury. Microvasc Res (2008) 1.06
Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol (2011) 1.05
Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. Neuroscience (2010) 1.04
Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest (2013) 1.02
Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents. Brain Res (2006) 1.02
Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. J Pharmacol Exp Ther (2009) 1.02
Rational modulation of the innate immune system for neuroprotection in ischemic stroke. Front Neurosci (2015) 1.02
The role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas. Clin Dev Immunol (2013) 1.01
Vascular PPARδ protects against stroke-induced brain injury. Arterioscler Thromb Vasc Biol (2011) 1.01
The blood-brain barrier. Cold Spring Harb Perspect Biol (2015) 1.00
Reperfusion activates metalloproteinases that contribute to neurovascular injury. Exp Neurol (2007) 1.00
Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling. Acta Neuropathol (2016) 1.00
Glyburide is associated with attenuated vasogenic edema in stroke patients. Neurocrit Care (2014) 1.00
Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats. Exp Neurol (2008) 1.00
A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system. J Cereb Blood Flow Metab (2010) 1.00
Protease regulation: the Yin and Yang of neural development and disease. Neuron (2011) 1.00
Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets. Curr Med Chem (2014) 0.99
Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke. Prog Neurobiol (2015) 0.99
Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke. Med Gas Res (2011) 0.98
Safety and efficacy of alteplase in the treatment of acute ischemic stroke. Vasc Health Risk Manag (2009) 0.98
Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke. Stroke (2011) 0.98
Genomic responses in rat cerebral cortex after traumatic brain injury. BMC Neurosci (2005) 0.97
The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury. J Neuroinflammation (2012) 0.97
Matrix metalloproteinases as therapeutic targets for stroke. Brain Res (2015) 0.97
Protection after stroke: cellular effectors of neurovascular unit integrity. Front Cell Neurosci (2014) 0.97
Does inhibiting Sur1 complement rt-PA in cerebral ischemia? Ann N Y Acad Sci (2012) 0.96
Matrix metalloproteinase-2 or -9 deletions protect against hemorrhagic transformation during early stage of cerebral ischemia and reperfusion. Neuroscience (2012) 0.96
Blood-brain barrier breakdown involves four distinct stages of vascular damage in various models of experimental focal cerebral ischemia. J Cereb Blood Flow Metab (2014) 0.96
Spatiotemporal correlations between blood-brain barrier permeability and apparent diffusion coefficient in a rat model of ischemic stroke. PLoS One (2009) 0.96
Mmp-9, a potential target for cerebral ischemic treatment. Curr Neuropharmacol (2009) 0.96
Different roles of matrix metalloproteinases-2 and -9 after human ischaemic stroke. Neurol Sci (2007) 0.96
Hypertension-induced vascular remodeling contributes to reduced cerebral perfusion and the development of spontaneous stroke in aged SHRSP rats. J Cereb Blood Flow Metab (2009) 0.96
Evidence for differential changes of junctional complex proteins in murine neurocysticercosis dependent upon CNS vasculature. Brain Res (2007) 0.96
Albumin induces upregulation of matrix metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathways. J Neuroinflammation (2012) 0.95
Body fluid biomarkers in multiple sclerosis: how far we have come and how they could affect the clinic now and in the future. Expert Rev Clin Immunol (2014) 0.94
Blood-brain barrier alterations provide evidence of subacute diaschisis in an ischemic stroke rat model. PLoS One (2013) 0.94
Inflammation in adult and neonatal stroke. Clin Neurosci Res (2006) 0.94
Blood-brain barrier disruption after cardiac surgery. AJNR Am J Neuroradiol (2012) 0.93
Temporal MRI assessment of intracerebral hemorrhage in rats. Stroke (2008) 0.93
Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis. J Neurosci Methods (2011) 0.93
Blood-brain barrier dysfunction in disorders of the developing brain. Front Neurosci (2015) 0.92
Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke. J Neurochem (2013) 0.90
Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia. J Mol Neurosci (2012) 0.90
Ischemia-reperfusion impairs blood-brain barrier function and alters tight junction protein expression in the ovine fetus. Neuroscience (2012) 0.90
Angiogenesis-regulating microRNAs and Ischemic Stroke. Curr Vasc Pharmacol (2015) 0.89
Involvement of metalloprotease-2 in the development of human brain microvessels. Histochem Cell Biol (2004) 0.88
Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia. J Cereb Blood Flow Metab (2009) 0.88
TIMP-1/MMP-9 imbalance in brain edema in rats with fulminant hepatic failure. J Surg Res (2006) 0.88
Expression of MMP-2,TIMP-2 protein and the ratio of MMP-2/TIMP-2 in gallbladder carcinoma and their significance. World J Gastroenterol (2002) 0.88
Pathogenesis of brain edema and investigation into anti-edema drugs. Int J Mol Sci (2015) 0.88
Chronic intrauterine hypoxia interferes with aortic development in the late gestation ovine fetus. J Physiol (2011) 0.87
Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells. Mol Neurobiol (2015) 0.86
Blood-brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury. Curr Opin Neurol (2015) 0.86
Endothelial cells and astrocytes: a concerto en duo in ischemic pathophysiology. Int J Cell Biol (2012) 0.86
Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation. J Neuroinflammation (2012) 0.86
Experimental treatment of stroke in spontaneously hypertensive rats by CD34+ and CD34- cord blood cells. Ger Med Sci (2005) 0.85
TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure. J Cereb Blood Flow Metab (2013) 0.85
Changes in interleukin-1 signal modulators induced by 3,4-methylenedioxymethamphetamine (MDMA): regulation by CB2 receptors and implications for neurotoxicity. J Neuroinflammation (2011) 0.85
Acute hepatocyte growth factor treatment induces long-term neuroprotection and stroke recovery via mechanisms involving neural precursor cell proliferation and differentiation. J Cereb Blood Flow Metab (2010) 0.84
Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain Res (2001) 1.90
Devic's neuromyelitis optica: a prospective study of seven patients treated with prednisone and azathioprine. Neurology (1998) 1.53
Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis. Am J Pathol (1998) 1.48
Tumor necrosis factor-alpha-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window. Brain Res (1995) 1.40
Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis: relation to blood-brain barrier injury. Neurology (1996) 1.24
Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain. Lab Invest (1994) 1.03
Neutral proteases and disruption of the blood-brain barrier in rat. Brain Res (1997) 0.94
Magnetic resonance lipid signals in rat brain after experimental stroke correlate with neutral lipid accumulation. Neurosci Lett (2001) 0.90
Atrial natriuretic peptide blocks hemorrhagic brain edema after 4-hour delay in rats. Stroke (1995) 0.81