Published in Front Neurol on June 30, 2015
Epigenetics in heart failure phenotypes. BBA Clin (2016) 0.78
Ischemia/Reperfusion. Compr Physiol (2016) 0.78
Epigenetic Regulation of Oxidative Stress in Ischemic Stroke. Aging Dis (2016) 0.77
Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats. Front Mol Neurosci (2016) 0.75
Long-term window of ischemic tolerance: An evolutionarily conserved form of metabolic plasticity regulated by epigenetic modifications? J Neurol Neuromedicine (2016) 0.75
Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System. Oxid Med Cell Longev (2017) 0.75
Molecular Bases of Brain Preconditioning. Front Neurosci (2017) 0.75
Translating the histone code. Science (2001) 56.77
Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet (2006) 37.83
Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation (2014) 22.74
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science (1996) 12.64
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature (2000) 8.59
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell (2003) 7.71
Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell (2008) 6.93
Acetylation and deacetylation of non-histone proteins. Gene (2005) 6.87
The FoxO code. Oncogene (2008) 6.22
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol (2007) 6.16
The science of stroke: mechanisms in search of treatments. Neuron (2010) 6.14
HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A (1996) 5.61
Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation (2000) 4.96
Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci (2006) 4.51
HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention. Oncogene (2007) 4.41
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell (2011) 3.64
New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res (2004) 3.63
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
Ischemic tolerance and endogenous neuroprotection. Trends Neurosci (2003) 3.44
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40
New and emerging HDAC inhibitors for cancer treatment. J Clin Invest (2014) 3.35
Class II histone deacetylases: from sequence to function, regulation, and clinical implication. Mol Cell Biol (2005) 3.05
Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology (2008) 3.04
Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol (2009) 2.98
Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther (2007) 2.90
'Ischemic tolerance' phenomenon found in the brain. Brain Res (1990) 2.73
Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation (1999) 2.40
Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc Res (2006) 2.30
Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res (2004) 2.25
Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia. J Neurosci (2007) 2.24
Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction. J Neurochem (2004) 2.21
Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation (2002) 2.14
Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways. J Biol Chem (1997) 2.12
Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res (2001) 2.09
Injury-induced HDAC5 nuclear export is essential for axon regeneration. Cell (2013) 2.09
HDAC4 regulates neuronal survival in normal and diseased retinas. Science (2009) 1.86
Ischemic postconditioning as a novel avenue to protect against brain injury after stroke. J Cereb Blood Flow Metab (2009) 1.77
Sodium 4-phenylbutyrate protects against cerebral ischemic injury. Mol Pharmacol (2004) 1.76
Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB J (2008) 1.76
Nuclear factor-kappaB plays an essential role in the late phase of ischemic preconditioning in conscious rabbits. Circ Res (1999) 1.75
Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain. Mol Pharmacol (2006) 1.67
A non-enzymatic p21 protein inhibitor of stress-activated protein kinases. Nature (1996) 1.66
Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning. Proc Natl Acad Sci U S A (2000) 1.60
Therapeutic potential for HDAC inhibitors in the heart. Annu Rev Pharmacol Toxicol (2011) 1.59
HDAC4 inhibits cell-cycle progression and protects neurons from cell death. Dev Neurobiol (2008) 1.56
Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway. J Cereb Blood Flow Metab (2005) 1.55
Chemical studies of histone acetylation. The occurrence of epsilon-N-acetyllysine in the f2a1 histone. J Biol Chem (1968) 1.53
The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. J Neurochem (2009) 1.53
DNA methyltransferase contributes to delayed ischemic brain injury. J Neurosci (2000) 1.50
Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta. J Neurosci (2011) 1.44
Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury. Cardiovasc Res (2007) 1.44
Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J Neurosci (2002) 1.43
Targeting histone deacetylases as a multifaceted approach to treat the diverse outcomes of stroke. Stroke (2009) 1.42
Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke. Apoptosis (2009) 1.39
Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt. Int J Cancer (2009) 1.36
Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. J Neurochem (2009) 1.28
Valproic acid-mediated neuroprotection and regeneration in injured retinal ganglion cells. Invest Ophthalmol Vis Sci (2009) 1.24
Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury. Exp Neurol (2007) 1.21
Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. J Biol Chem (2004) 1.20
Reperfusion injury salvage kinase and survivor activating factor enhancement prosurvival signaling pathways in ischemic postconditioning: two sides of the same coin. Antioxid Redox Signal (2010) 1.17
Oxygen-derived free radicals and postischemic myocardial dysfunction ("stunned myocardium"). J Am Coll Cardiol (1988) 1.17
Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol (2011) 1.14
An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia. FEBS Lett (1998) 1.14
p38 Triggers late preconditioning elicited by anisomycin in heart: involvement of NF-kappaB and iNOS. Circ Res (2001) 1.13
Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis. J Pharmacol Exp Ther (2012) 1.12
PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol (2000) 1.12
Up-regulation of endothelial nitric oxide synthase via phosphatidylinositol 3-kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil hippocampus. J Cereb Blood Flow Metab (2004) 1.11
Inhibition of histone deacetylase protects the retina from ischemic injury. Invest Ophthalmol Vis Sci (2010) 1.10
Valproic acid increases white matter repair and neurogenesis after stroke. Neuroscience (2012) 1.09
Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death. J Biol Chem (2012) 1.07
Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibition. Am J Physiol Heart Circ Physiol (2010) 1.06
Protein kinase C epsilon-Src modules direct signal transduction in nitric oxide-induced cardioprotection: complex formation as a means for cardioprotective signaling. Circ Res (2001) 1.06
Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage. Free Radic Biol Med (2011) 1.05
Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia-reperfusion injury. Neurosci Lett (2011) 1.04
Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism. J Biol Chem (2010) 1.04
Clinical application of preconditioning and postconditioning to achieve neuroprotection. Transl Stroke Res (2012) 1.02
Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke. Stroke (2012) 1.01
gp-91 mediates histone deacetylase inhibition-induced cardioprotection. Biochim Biophys Acta (2010) 1.01
Ischemic preconditioning alters the epigenetic profile of the brain from ischemic intolerance to ischemic tolerance. Neurotherapeutics (2013) 1.01
Benefits of histone deacetylase inhibitors for acute brain injury: a systematic review of animal studies. J Neurochem (2010) 0.97
Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells. Carcinogenesis (2013) 0.96
Expression patterns of histone deacetylases in experimental stroke and potential targets for neuroprotection. Clin Exp Pharmacol Physiol (2012) 0.94
Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window. Neurobiol Dis (2012) 0.94
Epigenetic mechanisms in cerebral ischemia. J Cereb Blood Flow Metab (2013) 0.93
HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. J Cell Mol Med (2013) 0.92
Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons. Neuropharmacology (2010) 0.92
Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion. J Mol Cell Cardiol (2014) 0.90
Interplay between HDAC6 and its interacting partners: essential roles in the aggresome-autophagy pathway and neurodegenerative diseases. DNA Cell Biol (2014) 0.90
Expression of histone deacetylases in cellular compartments of the mouse brain and the effects of ischemia. Transl Stroke Res (2011) 0.88
Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity. J Biol Chem (2013) 0.88
HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1. PLoS One (2013) 0.87
Inhibition of HDAC2 protects the retina from ischemic injury. Invest Ophthalmol Vis Sci (2013) 0.86
Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2. Cell Death Dis (2010) 0.86
The role of MAP kinases in trauma and ischemia-reperfusion. J Invest Surg (2004) 0.86
Loss of endoplasmic reticulum Ca2+ homeostasis: contribution to neuronal cell death during cerebral ischemia. Acta Pharmacol Sin (2012) 0.85
Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. Exp Eye Res (2014) 0.85
HSP70 heat shock gene regulation during ischemia. Stroke (1993) 0.84