Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon.

IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs. Oncotarget (2016) 0.77

Comprehensive site-specific whole genome profiling of stromal and epithelial colonic gene signatures in human sigmoid colon and rectal tissue. Physiol Genomics (2016) 0.76

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer. Genes Dev (2016) 0.75

IMP1, an mRNA binding protein that reduces the metastatic potential of breast cancer in a mouse model. Oncotarget (2016) 0.75

IMPlicating Mesenchymal Imp1 in Colitis-Associated Cancer. Mol Cancer Res (2015) 0.75

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature (2012) 10.39

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol (2010) 7.73

Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol (2011) 6.17

Characterization of a beta-actin mRNA zipcode-binding protein. Mol Cell Biol (1997) 5.21

Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development (2003) 4.63

Intestinal inflammation and cancer. Gastroenterology (2011) 4.13

Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology (2003) 4.10

Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol (1998) 2.76

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer. Nat Genet (2015) 2.76

Stromal contribution to the colorectal cancer transcriptome. Nat Genet (2015) 2.59

CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. Mol Cell (2009) 2.38

CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. Nature (2006) 2.35

The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies. J Carcinog (2011) 2.30

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. Semin Cell Dev Biol (2009) 2.25

The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes Dev (2007) 2.16

Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol (2004) 2.08

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell (2013) 1.86

Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice. Gastroenterology (2012) 1.77

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nat Med (2014) 1.72

Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Cancer Res (2004) 1.62

A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth. Oncogene (2006) 1.56

HGF rescues colorectal cancer cells from EGFR inhibition via MET activation. Clin Cancer Res (2010) 1.50

Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A (2014) 1.46

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion. Proc Natl Acad Sci U S A (2010) 1.37

Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer. Int J Cancer (2007) 1.35

The tumor microenvironment in colorectal carcinogenesis. Cancer Microenviron (2010) 1.23

LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev (2013) 1.23

The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation. J Cell Sci (2010) 1.21

IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev (2012) 1.20

Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development (2008) 1.15

ZBP1 enhances cell polarity and reduces chemotaxis. J Cell Sci (2007) 1.11

Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepatocyte growth factor. Am J Physiol (1998) 1.11

IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. Cancer Res (2011) 1.07

Functional expression of HGF and its receptor in human colorectal cancer. Digestion (2000) 1.05

Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1. J Cell Sci (2012) 1.05

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J Clin Invest (2012) 1.05

MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors. Cancer Res (2014) 1.02

A role for VICKZ proteins in the progression of colorectal carcinomas: regulating lamellipodia formation. J Pathol (2008) 1.01

A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife (2013) 0.99

VICKZ proteins mediate cell migration via their RNA binding activity. RNA (2007) 0.99

Serum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancer. Br J Cancer (2014) 0.97

IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis (2013) 0.92

Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions. Genes Cancer (2010) 0.92

Mouse models for colorectal cancer. Am J Cancer Res (2013) 0.91

Bone morphogenetic protein antagonist gremlin-1 regulates colon cancer progression. Biol Chem (2015) 0.90

Expression of the hepatocyte growth factor and c-Met in colon cancer: correlation with clinicopathological features and overall survival. Tumori (2012) 0.90

Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells. J Biol Chem (2015) 0.81

Culturing adult stem cells from mouse small intestinal crypts. Cold Spring Harb Protoc (2015) 0.78

Registered report: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Elife (2014) 0.78