Published in Nature on June 15, 2006
Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell (2009) 10.50
MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91
Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle (2009) 3.68
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature (2008) 2.84
CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. Mol Cell (2009) 2.38
ZBP1 regulates mRNA stability during cellular stress. J Cell Biol (2006) 1.84
Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer. J Cell Biochem (2008) 1.77
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature (2015) 1.75
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci (2012) 1.68
Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol. Carcinogenesis (2010) 1.67
MYC and Breast Cancer. Genes Cancer (2010) 1.66
Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA (2008) 1.63
Quantifying Protein-mRNA Interactions in Single Live Cells. Cell (2015) 1.57
c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1. Mol Cell Biol (2007) 1.50
Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon. Mol Cancer Res (2015) 1.44
Retracted MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein. J Biol Chem (2010) 1.32
Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration. Prostate (2009) 1.30
CRD-BP shields c-myc and MDR-1 RNA from endonucleolytic attack by a mammalian endoribonuclease. Nucleic Acids Res (2007) 1.29
APC and its modifiers in colon cancer. Adv Exp Med Biol (2009) 1.28
Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1. Int J Cancer (2011) 1.27
Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR. Nucleic Acids Res (2006) 1.27
Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA. Cancer Res (2009) 1.16
Cullins and cancer. Genes Cancer (2010) 1.16
ZBP1 enhances cell polarity and reduces chemotaxis. J Cell Sci (2007) 1.11
IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. Cancer Res (2011) 1.07
RNA localization and polarity: from A(PC) to Z(BP). Trends Cell Biol (2009) 1.07
Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1. J Cell Sci (2012) 1.05
Feedback regulation between zipcode binding protein 1 and beta-catenin mRNAs in breast cancer cells. Mol Cell Biol (2008) 1.04
Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome. BMC Cancer (2010) 1.02
Feedback regulation of c-Myc by ribosomal protein L11. Cell Cycle (2007) 1.02
Cross-Regulation Between Wnt and NF-κB Signaling Pathways. For Immunopathol Dis Therap (2010) 1.01
A role for VICKZ proteins in the progression of colorectal carcinomas: regulating lamellipodia formation. J Pathol (2008) 1.01
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife (2013) 0.99
RNA-binding protein insulin-like growth factor mRNA-binding protein 3 (IMP-3) promotes cell survival via insulin-like growth factor II signaling after ionizing radiation. J Biol Chem (2011) 0.98
Coding region: the neglected post-transcriptional code. RNA Biol (2011) 0.95
cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b. Mol Endocrinol (2009) 0.95
Motility screen identifies Drosophila IGF-II mRNA-binding protein--zipcode-binding protein acting in oogenesis and synaptogenesis. PLoS Genet (2008) 0.95
Blocking beta-catenin binding to the ZBP1 promoter represses ZBP1 expression, leading to increased proliferation and migration of metastatic breast-cancer cells. J Cell Sci (2009) 0.93
IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis (2013) 0.92
Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions. Genes Cancer (2010) 0.92
Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents. Pigment Cell Melanoma Res (2011) 0.91
Role of CRD-BP in the growth of human basal cell carcinoma cells. J Invest Dermatol (2014) 0.87
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b. Cell (2016) 0.87
The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. J Biol Chem (2009) 0.84
The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt/β-catenin signaling. Mol Nutr Food Res (2013) 0.83
Integrative analysis of cancer-related signaling pathways. Front Physiol (2013) 0.83
IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). Nucleic Acids Res (2013) 0.82
Towards unraveling the human tooth transcriptome: the dentome. PLoS One (2015) 0.82
MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP). J Biol Chem (2014) 0.82
Involvement of the mRNA binding protein CRD-BP in the regulation of metastatic melanoma cell proliferation and invasion by hypoxia. J Cell Sci (2012) 0.81
Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1. Sarcoma (2015) 0.81
Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells. J Biol Chem (2015) 0.81
High-throughput fluorescence anisotropy screen for inhibitors of the oncogenic mRNA binding protein, IMP-1. J Biomol Screen (2013) 0.81
Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation. Front Immunol (2016) 0.81
Molecular insights into the coding region determinant-binding protein-RNA interaction through site-directed mutagenesis in the heterogeneous nuclear ribonucleoprotein-K-homology domains. J Biol Chem (2014) 0.80
cAMP stimulation of StAR expression and cholesterol metabolism is modulated by co-expression of labile suppressors of transcription and mRNA turnover. Mol Cell Endocrinol (2010) 0.79
Assessing specific oligonucleotides and small molecule antibiotics for the ability to inhibit the CRD-BP-CD44 RNA interaction. PLoS One (2014) 0.79
The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic Acids Res (2016) 0.79
Humoral autoimmune responses to insulin-like growth factor II mRNA-binding proteins IMP1 and p62/IMP2 in ovarian cancer. J Immunol Res (2014) 0.79
Abnormal retinal development in the Btrc null mouse. Dev Dyn (2009) 0.78
Vg1RBP phosphorylation by Erk2 MAP kinase correlates with the cortical release of Vg1 mRNA during meiotic maturation of Xenopus oocytes. RNA (2009) 0.78
Role of β-TrCP ubiquitin ligase receptor in UVB mediated responses in skin. Arch Biochem Biophys (2010) 0.77
Cloning and bioactivity analysis of a CXC ligand in black seabream Acanthopagrus schlegeli: the evolutionary clues of ELR+CXC chemokines. BMC Immunol (2008) 0.76
The complexity of epigenetic diseases. J Pathol (2015) 0.76
Allele-specific transcriptional elongation regulates monoallelic expression of the IGF2BP1 gene. Epigenetics Chromatin (2011) 0.76
MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications. Dis Model Mech (2017) 0.75
IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer. Genes Dev (2016) 0.75
Characterizing the Coding Region Determinant-Binding Protein (CRD-BP)-Microphthalmia-associated Transcription Factor (MITF) mRNA interaction. PLoS One (2017) 0.75
RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma. J Invest Dermatol (2016) 0.75
Both Maintenance and Avoidance of RNA-Binding Protein Interactions Constrain Coding Sequence Evolution. Mol Biol Evol (2017) 0.75
Implications of PPPDE1 expression in the distribution of plakoglobin and β-catenin in pancreatic ductal adenocarcinoma. Oncol Lett (2014) 0.75
Yes-associated protein: A novel molecular target for the diagnosis, treatment and prognosis of hepatocellular carcinoma. Oncol Lett (2017) 0.75
Aerobic Glycolysis Hypothesis Through WNT/Beta-Catenin Pathway in Exudative Age-Related Macular Degeneration. J Mol Neurosci (2017) 0.75
A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation. Transl Oncol (2017) 0.75
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell (2006) 3.08
The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene (2004) 2.94
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J (2006) 2.84
CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. Mol Cell (2009) 2.38
SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J (2003) 2.16
Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochem Biophys Res Commun (2005) 2.08
Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. J Cell Biol (2007) 2.07
S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9. Proc Natl Acad Sci U S A (2006) 1.87
Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. J Biol Chem (2004) 1.87
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest (2012) 1.85
Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol. Carcinogenesis (2010) 1.67
Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Cancer Res (2004) 1.62
Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase. J Biol Chem (2006) 1.51
Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor. Blood (2011) 1.49
Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host Microbe (2009) 1.46
Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant. Mol Cell Biol (2002) 1.43
Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway. Mol Cell Biol (2008) 1.41
Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer. J Natl Cancer Inst (2004) 1.41
Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents. Cancer Sci (2007) 1.40
TYK2 activity promotes ligand-induced IFNAR1 proteolysis. Biochem J (2006) 1.39
Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase. Mol Cell Biol (2004) 1.34
Retracted MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein. J Biol Chem (2010) 1.32
Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa. Cancer Sci (2007) 1.31
Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Cancer Res (2007) 1.30
miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner. Mol Cell (2012) 1.27
Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer. Clin Cancer Res (2010) 1.27
Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma. Clin Cancer Res (2009) 1.23
Ligand-independent pathway that controls stability of interferon alpha receptor. Biochem Biophys Res Commun (2007) 1.21
Oncogenic beta-catenin signaling networks in colorectal cancer. Cell Cycle (2005) 1.21
Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing. Gastroenterology (2010) 1.20
Elevated expression of Wnt antagonists is a common event in hepatoblastomas. Clin Cancer Res (2005) 1.20
ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis. J Clin Invest (2015) 1.17
Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells. Cancer Res (2005) 1.16
Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA. Cancer Res (2009) 1.16
Oncogenic beta-catenin and MMP-7 (matrilysin) cosegregate in late-stage clinical colon cancer. Gastroenterology (2002) 1.15
Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans. Gastroenterology (2010) 1.13
Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. Mol Cell Biol (2009) 1.13
The cell biology of the unfolded protein response. Gastroenterology (2011) 1.11
Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling. J Biol Chem (2002) 1.11
Stability of homologue of Slimb F-box protein is regulated by availability of its substrate. J Biol Chem (2004) 1.11
Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells. Prostate (2002) 1.10
Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase. Oncogene (2004) 1.10
Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells. J Invest Dermatol (2009) 1.10
SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGF-beta homeostasis in lung cancer cells. Cancer Res (2008) 1.09
Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor. J Biol Chem (2009) 1.09
The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development. Gastroenterology (2008) 1.08
IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. Cancer Res (2011) 1.07
Impaired turnover of prolactin receptor contributes to transformation of human breast cells. Cancer Res (2009) 1.06
Oncogene-mediated inhibition of glycogen synthase kinase 3 beta impairs degradation of prolactin receptor. Cancer Res (2008) 1.06
Different histological types of non-small cell lung cancer have distinct folate and DNA methylation levels. Cancer Sci (2009) 1.05
Dynamics of Golgi matrix proteins after the blockage of ER to Golgi transport. J Biochem (2004) 1.05
Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase. Clin Cancer Res (2009) 1.03
Determinants of growth hormone receptor down-regulation. Mol Endocrinol (2007) 1.00
Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine. J Gastroenterol (2011) 1.00
Inhibition of HOS expression and activities by Wnt pathway. Oncogene (2002) 1.00
Induction and down-regulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis. Gastroenterology (2009) 0.99
Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif. J Biol Chem (2008) 0.99
Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2. J Endocrinol (2008) 0.98
Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis. Blood (2011) 0.98
Genome-wide survey of interindividual differences of RNA stability in human lymphoblastoid cell lines. Sci Rep (2013) 0.98
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3 beta. Anticancer Agents Med Chem (2009) 0.96
Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction. J Tissue Eng Regen Med (2007) 0.96
Expression of alphav integrin family in gastric carcinomas: increased alphavbeta6 is associated with lymph node metastasis. Pathol Res Pract (2003) 0.95
Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells. World J Gastroenterol (2006) 0.95
Activation of Wnt/beta-catenin/Tcf signaling in mouse skin carcinogenesis. Mol Carcinog (2005) 0.95
Ubiquitination-dependent regulation of signaling receptors in cancer. Genes Cancer (2010) 0.94
Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1. PLoS Pathog (2011) 0.94
Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy. PLoS One (2013) 0.94
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses. Cell Rep (2013) 0.93
MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression. PLoS One (2011) 0.93
Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells. Cancer Biol Ther (2007) 0.93
LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer. BMC Cancer (2012) 0.93
IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis (2013) 0.92
Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/beta-TrCP E3 ubiquitin ligase regulates extent of NF-kappaB activation. J Biol Chem (2003) 0.92
Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions. Genes Cancer (2010) 0.92
C-kit gene mutation: common and widely distributed in intracranial germinomas. J Neurosurg (2006) 0.92
Numb regulates stability and localization of the mitotic kinase PLK1 and is required for transit through mitosis. Cancer Res (2012) 0.91
Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents. Pigment Cell Melanoma Res (2011) 0.91
beta-Catenin and ras oncogenes detect most human colorectal cancer. Clin Cancer Res (2003) 0.90
Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor. J Biol Chem (2011) 0.90