Lanosterol reverses protein aggregation in cataracts.

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🔗 View Article (PMID 26200341)

Published in Nature on July 22, 2015

Authors

Ling Zhao1, Xiang-Jun Chen2, Jie Zhu3, Yi-Bo Xi2, Xu Yang4, Li-Dan Hu2, Hong Ouyang5, Sherrina H Patel6, Xin Jin4, Danni Lin6, Frances Wu6, Ken Flagg6, Huimin Cai7, Gen Li8, Guiqun Cao8, Ying Lin5, Daniel Chen6, Cindy Wen6, Christopher Chung6, Yandong Wang9, Austin Qiu10, Emily Yeh6, Wenqiu Wang11, Xun Hu8, Seanna Grob6, Ruben Abagyan12, Zhiguang Su8, Harry Christianto Tjondro2, Xi-Juan Zhao2, Hongrong Luo6, Rui Hou13, J Jefferson, P Perry14, Weiwei Gao15, Igor Kozak16, David Granet6, Yingrui Li4, Xiaodong Sun17, Jun Wang4, Liangfang Zhang15, Yizhi Liu9, Yong-Bin Yan18, Kang Zhang19

Author Affiliations

1: 1] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China [3] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.
2: State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
3: 1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
4: BGI-Shenzhen, Shenzhen 518083, China.
5: 1] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China [2] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.
6: Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.
7: 1] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2] Guangzhou KangRui Biological Pharmaceutical Technology Company, Guangzhou 510005, China.
8: Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
9: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
10: 1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] CapitalBio Genomics Co., Ltd., Dongguan 523808, China.
11: 1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] Department of Ophthalmology, Shanghai First People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 20080, China.
12: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, USA.
13: Guangzhou KangRui Biological Pharmaceutical Technology Company, Guangzhou 510005, China.
14: Department of Biochemistry, University of California Riverside, Riverside, California 92521, USA.
15: 1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA.
16: King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.
17: Department of Ophthalmology, Shanghai First People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 20080, China.
18: Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
19: 1] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China [3] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [4] Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA [5] Veterans Administration Healthcare System, San Diego, California 92093, USA.

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