TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 complex in T-cell acute lymphoblastic leukemia.

PubWeight™: 0.76^‹?›

🔗 View Article (PMID 26202930)

Published in Leukemia on July 23, 2015

Authors

S H Tan¹, A W Y Yam¹, L N Lawton², R W J Wong¹, R A Young²^,3, A T Look⁴^,5, T Sanda¹^,6

Author Affiliations

1: Cancer Science Institute of Singapore, National University of Singapore, Singapore.
2: Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
3: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
4: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
5: Division of Hematology/Oncology, Children's Hospital, Boston, MA, USA.
6: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Articles citing this ↘

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease. Trends Cell Biol (2016) 0.78

Articles cited by this ↗

Oncogenic transcription factors in the human acute leukemias. Science (1997) 6.45

IAPs: what's in a name? Mol Cell (2008) 3.66

Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol (2008) 3.57

The molecular basis of T cell acute lymphoblastic leukemia. J Clin Invest (2012) 3.09

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science (2014) 2.91

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood (2007) 2.77

E and ID proteins branch out. Nat Rev Immunol (2009) 2.68

Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes. J Exp Med (1993) 2.23

TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell (2004) 1.88

Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell (2006) 1.76

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol (1998) 1.49

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell (2012) 1.43

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood (2010) 1.27

Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood (2007) 1.19

Site- and allele-specific polycomb dysregulation in T-cell leukaemia. Nat Commun (2015) 0.92

Articles by these authors ⇆

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. Leukemia (2017) 0.77

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia. Leukemia (2015) 0.76

Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Leukemia (2016) 0.75