Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.

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Published in Science on November 13, 2014

Authors

Marc R Mansour1, Brian J Abraham2, Lars Anders2, Alla Berezovskaya3, Alejandro Gutierrez4, Adam D Durbin3, Julia Etchin3, Lee Lawton2, Stephen E Sallan4, Lewis B Silverman4, Mignon L Loh5, Stephen P Hunger6, Takaomi Sanda7, Richard A Young8, A Thomas Look9

Author Affiliations

1: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6BT, UK.
2: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
3: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
4: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Division of Pediatric Hematology-Oncology, Boston Children's Hospital, MA 02115, USA.
5: Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, CA 94143, USA.
6: Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO 80045, USA.
7: Cancer Science Institute of Singapore, National University of Singapore, and Department of Medicine, Yong Loo Lin School of Medicine, 117599, Singapore.
8: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. thomas_look@dfci.harvard.edu young@wi.mit.edu.
9: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Division of Pediatric Hematology-Oncology, Boston Children's Hospital, MA 02115, USA. thomas_look@dfci.harvard.edu young@wi.mit.edu.

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