Published in Curr Opin Immunol on July 23, 2015
Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure. CNS Neurol Disord Drug Targets (2016) 0.76
Warburg effect linked to cognitive-executive deficits in FMR1 premutation. FASEB J (2016) 0.75
Brucella abortus induces a Warburg shift in host metabolism that is linked to enhanced intracellular survival of the pathogen. J Bacteriol (2017) 0.75
Abscisic acid induces a transient shift in signaling that enhances NF-κB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity. Parasit Vectors (2017) 0.75
Pathogen recognition and innate immunity. Cell (2006) 44.14
TLR signaling. Semin Immunol (2007) 8.16
The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochem J (1993) 4.96
Quantifying the risk of infectious diseases for people with diabetes. Diabetes Care (2003) 3.45
Mitochondria in innate immune responses. Nat Rev Immunol (2011) 3.31
Severe hypoglycemia and hyperinsulinemia in falciparum malaria. N Engl J Med (1983) 3.07
Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab (2001) 3.05
Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites. J Exp Med (1993) 2.88
Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem (2000) 2.44
Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia (2006) 2.07
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med (2013) 2.06
Evolution of insect P450. Biochem Soc Trans (2006) 2.03
IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J Endocrinol (2002) 2.01
Kinase signaling cascades in the mitochondrion: a matter of life or death. Free Radic Biol Med (2005) 1.93
The cytochrome P450 gene superfamily in Drosophila melanogaster: annotation, intron-exon organization and phylogeny. Gene (2001) 1.90
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nat Cell Biol (2011) 1.77
Activation of Akt signaling reduces the prevalence and intensity of malaria parasite infection and lifespan in Anopheles stephensi mosquitoes. PLoS Pathog (2010) 1.74
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm IGF Res (2008) 1.72
Effects of para-aminobenzoic acid, insulin, and gentamicin on Plasmodium falciparum development in anopheline mosquitoes (Diptera: Culicidae). J Med Entomol (1994) 1.61
Induction of nitric oxide synthase in Anopheles stephensi by Plasmodium falciparum: mechanism of signaling and the role of parasite glycosylphosphatidylinositols. Infect Immun (2005) 1.50
Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis. J Biol Chem (2000) 1.48
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. J Immunol (2009) 1.48
Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proc Natl Acad Sci U S A (2000) 1.46
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature (2014) 1.40
Hemozoin induces macrophage chemokine expression through oxidative stress-dependent and -independent mechanisms. J Immunol (2005) 1.36
The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. J Immunol (2003) 1.32
Mitochondria in innate immunity. EMBO Rep (2011) 1.31
Hemozoin increases IFN-gamma-inducible macrophage nitric oxide generation through extracellular signal-regulated kinase- and NF-kappa B-dependent pathways. J Immunol (2003) 1.29
Transcriptome response to pollutants and insecticides in the dengue vector Aedes aegypti using next-generation sequencing technology. BMC Genomics (2010) 1.27
The insulin signaling cascade from nematodes to mammals: insights into innate immunity of Anopheles mosquitoes to malaria parasite infection. Dev Comp Immunol (2006) 1.21
Placental malaria-associated inflammation disturbs the insulin-like growth factor axis of fetal growth regulation. J Infect Dis (2011) 1.18
Type 2 diabetes mellitus and increased risk for malaria infection. Emerg Infect Dis (2010) 1.18
Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death. Mol Cell Biol (2007) 1.14
Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis. Free Radic Biol Med (2008) 1.14
Insulin regulates aging and oxidative stress in Anopheles stephensi. J Exp Biol (2008) 1.11
The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells. J Cell Physiol (2008) 1.11
Distribution and spread of pyrethroid and DDT resistance among the Anopheles gambiae complex in Tanzania. Med Vet Entomol (2013) 1.10
Reactive oxygen species-dependent cell signaling regulates the mosquito immune response to Plasmodium falciparum. Antioxid Redox Signal (2011) 1.06
Enhanced Toll-like receptor responsiveness associated with mitogen-activated protein kinase activation in Plasmodium falciparum-infected children. Infect Immun (2008) 1.05
Ingested human insulin inhibits the mosquito NF-κB-dependent immune response to Plasmodium falciparum. Infect Immun (2012) 1.03
Decreased detoxification genes and genome size make the human body louse an efficient model to study xenobiotic metabolism. Insect Mol Biol (2010) 1.03
The human insulin superfamily of polypeptide hormones. Vitam Horm (2009) 1.02
Molecular characterization of insulin-like peptide genes and their expression in the African malaria mosquito, Anopheles gambiae. Insect Mol Biol (2004) 1.02
Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host. PLoS Pathog (2013) 1.01
Induction of nitric oxide synthase and activation of signaling proteins in Anopheles mosquitoes by the malaria pigment, hemozoin. Infect Immun (2007) 1.01
Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction. Am J Pathol (2012) 1.01
Mitochondria: commanders of innate immunity and disease? Curr Opin Immunol (2011) 1.01
Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53. PLoS One (2012) 1.00
A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila. Dev Cell (2011) 0.99
Glycosyl-phosphatidylinositol molecules of the parasite and the host. Parasitology (1994) 0.99
A mass spectrometric method for quantitation of intact insulin in blood samples. J Anal Toxicol (2001) 0.97
Insulin-like peptides in the mosquito Anopheles stephensi: identification and expression in response to diet and infection with Plasmodium falciparum. Gen Comp Endocrinol (2011) 0.95
Toxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background. Toxicol Sci (2013) 0.94
The mitogen-activated protein kinome from Anopheles gambiae: identification, phylogeny and functional characterization of the ERK, JNK and p38 MAP kinases. BMC Genomics (2011) 0.94
Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress. Free Radic Biol Med (2009) 0.93
The immunogenic properties of protozoan glycosylphosphatidylinositols in the mosquito Anopheles gambiae. Dev Comp Immunol (2008) 0.93
Reversal of type 2 diabetes in mice by products of malaria parasites. II. Role of inositol phosphoglycans (IPGs). Mol Genet Metab (2001) 0.92
The effects of ingested mammalian blood factors on vector arthropod immunity and physiology. Microbes Infect (2013) 0.91
Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi. Microbes Infect (2013) 0.91
Hydrogen sulfide donor NaHS reduces organ injury in a rat model of pneumococcal pneumosepsis, associated with improved bio-energetic status. PLoS One (2013) 0.90
The IL-12p70/IL-10 interplay is differentially regulated by free heme and hemozoin in murine bone-marrow-derived macrophages. Int J Parasitol (2010) 0.90
Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1. Exp Parasitol (2011) 0.90
Reciprocal regulation of glutathione S-transferase spliceforms and the Drosophila c-Jun N-terminal kinase pathway components. Biochem J (2004) 0.90
A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites. Cell Host Microbe (2013) 0.89
Protein kinase C-theta is required for development of experimental cerebral malaria. Am J Pathol (2010) 0.89
Function and characteristics of PINK1 in mitochondria. Oxid Med Cell Longev (2013) 0.89
Function of GRIM-19, a mitochondrial respiratory chain complex I protein, in innate immunity. J Biol Chem (2012) 0.88
Structure and activity of glycosylphosphatidylinositol anchors of Plasmodium falciparum. Microbes Infect (2002) 0.88
Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi. PLoS Pathog (2014) 0.88
Malarial toxic antigens synergistically enhance insulin signalling. FEBS Lett (1992) 0.88
Phylogenetic analysis of coccidian parasites from invertebrates: search for missing links. Protist (2006) 0.87
Prevalence of malaria and its relationship to anemia, blood glucose levels, and serum somatomedin c (IGF-1) levels in the Solomon Islands. Acta Trop (1994) 0.87
Haemozoin induces early cytokine-mediated lysozyme release from human monocytes through p38 MAPK- and NF-kappaB-dependent mechanisms. PLoS One (2012) 0.87
Structural similarities among malaria toxins insulin second messengers, and bacterial endotoxin. Infect Immun (1996) 0.84
Insulin regulates macrophage activation through activin A. Shock (2008) 0.84
c-Jun N terminal kinases (JNK) are activated in the brain during the pathology of experimental cerebral malaria. Neurosci Lett (2010) 0.82
Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-kappaB activation in alveolar macrophages. Cell Physiol Biochem (2008) 0.82
Improvement of glucose homeostasis in obese diabetic db/db mice given Plasmodium yoelii glycosylphosphatidylinositols. Metabolism (2004) 0.81
Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex. FASEB J (2012) 0.80
Natural haemozoin induces expression and release of human monocyte tissue inhibitor of metalloproteinase-1. PLoS One (2013) 0.80
Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes. PLoS One (2013) 0.79
Involvement of p38 MAPK in haemozoin-dependent MMP-9 enhancement in human monocytes. Cell Biochem Funct (2013) 0.79
MAVS-mediated host cell defense is inhibited by Borna disease virus. Int J Biochem Cell Biol (2013) 0.79
Mitochondrial anomalies are associated with the induction of intrinsic cell death proteins-Bcl(2), Bax, cytochrome-c and p53 in mice brain during experimental fatal murine cerebral malaria. Neurosci Lett (2002) 0.78
The specific, reversible JNK inhibitor SP600125 improves survivability and attenuates neuronal cell death in experimental cerebral malaria (ECM). Parasitol Res (2013) 0.78
Over-transcription of genes in a parathion-resistant strain of mosquito Culex pipiens quinquefasciatus. Insect Sci (2014) 0.78
Reversal of type 2 diabetes in mice by products of malaria parasites: I. Effect of inactivated parasites. Metabolism (2000) 0.78
CD36 modulates proinflammatory cytokine responses to Plasmodium falciparum glycosylphosphatidylinositols and merozoites by dendritic cells. Parasite Immunol (2012) 0.77
Plasmodium falciparum suppresses the host immune response by inducing the synthesis of insulin-like peptides (ILPs) in the mosquito Anopheles stephensi. Dev Comp Immunol (2015) 0.76
cAMP-dependent protein kinase regulates post-translational processing and expression of complex I subunits in mammalian cells. Biochim Biophys Acta (2010) 0.76
Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection. Parasit Vectors (2015) 0.76