Published in Am J Pathol on January 17, 2012
Pathogenesis of cerebral malaria--inflammation and cytoadherence. Front Cell Infect Microbiol (2014) 1.06
Stuck in a rut? Reconsidering the role of parasite sequestration in severe malaria syndromes. Trends Parasitol (2013) 0.97
Contrasting pediatric and adult cerebral malaria: the role of the endothelial barrier. Virulence (2013) 0.96
Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. Am J Trop Med Hyg (2015) 0.96
Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN. J Am Soc Nephrol (2015) 0.84
Sepsis and ARDS: The Dark Side of Histones. Mediators Inflamm (2015) 0.83
Histone cleavage as a mechanism for epigenetic regulation: current insights and perspectives. Curr Mol Med (2014) 0.81
Organ distribution of histones after intravenous infusion of FITC histones or after sepsis. Immunol Res (2015) 0.81
Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo. PLoS Pathog (2015) 0.81
A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria. PLoS One (2013) 0.80
P. falciparum isolate-specific distinct patterns of induced apoptosis in pulmonary and brain endothelial cells. PLoS One (2014) 0.80
Cytokine network in adults with falciparum Malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity. PLoS One (2014) 0.78
EPCR and Malaria Severity: The Center of a Perfect Storm. Trends Parasitol (2016) 0.77
CD36 and Fyn kinase mediate malaria-induced lung endothelial barrier dysfunction in mice infected with Plasmodium berghei. PLoS One (2013) 0.77
Neutrophil Extracellular Traps Go Viral. Front Immunol (2016) 0.77
Host-pathogen interactions in malaria: cross-kingdom signaling and mitochondrial regulation. Curr Opin Immunol (2015) 0.76
Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI. J Am Soc Nephrol (2017) 0.75
Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation. Cell Death Dis (2016) 0.75
Dynamic interactions of Plasmodium spp. with vascular endothelium. Tissue Barriers (2016) 0.75
Breaking down brain barrier breaches in cerebral malaria. J Clin Invest (2016) 0.75
Neutrophil-mediated vascular barrier injury: Role of neutrophil extracellular traps. Microcirculation (2017) 0.75
Selective Biological Responses of Phagocytes and Lungs to Purified Histones. J Innate Immun (2017) 0.75
Dysregulation of pulmonary endothelial protein C receptor and thrombomodulin in severe falciparum malaria-associated ARDS relevant to hemozoin. PLoS One (2017) 0.75
Extracellular histones disarrange vasoactive mediators release through a COX-NOS interaction in human endothelial cells. J Cell Mol Med (2017) 0.75
Reduction in serum sphingosine 1-phosphate concentration in malaria. PLoS One (2017) 0.75
Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med (2001) 27.70
Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature (2006) 24.43
Neutrophil extracellular traps kill bacteria. Science (2004) 23.64
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature (2007) 8.88
Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet (1998) 6.88
Bactericidal action of histone. J Exp Med (1958) 6.58
Extracellular histones are major mediators of death in sepsis. Nat Med (2009) 6.55
The cytoprotective protein C pathway. Blood (2006) 5.75
HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol (2010) 5.65
Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med (2005) 4.65
A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N Engl J Med (1996) 4.64
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med (2005) 3.85
Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells. Blood (2002) 3.70
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. Proc Natl Acad Sci U S A (2007) 3.41
Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood (2011) 3.25
Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One (2009) 2.93
Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites. J Exp Med (1993) 2.88
Elevated nucleosome levels in systemic inflammation and sepsis. Crit Care Med (2003) 2.76
Quantitative detection of Plasmodium falciparum DNA in saliva, blood, and urine. J Infect Dis (2009) 2.64
Malaria parasite proteins that remodel the host erythrocyte. Nat Rev Microbiol (2009) 2.62
The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria. J Infect Dis (1999) 2.49
The effects of multiplication and synchronicity on the vascular distribution of parasites in falciparum malaria. Trans R Soc Trop Med Hyg (1993) 2.40
Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species. Malar J (2008) 2.30
Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers. J Infect Dis (2007) 2.11
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog (2009) 2.07
Systemic endothelial activation occurs in both mild and severe malaria. Correlating dermal microvascular endothelial cell phenotype and soluble cell adhesion molecules with disease severity. Am J Pathol (1998) 2.05
Molecular mechanisms of cytoadherence in malaria. Am J Physiol (1999) 1.77
Blood-brain barrier function in cerebral malaria in Malawian children. Am J Trop Med Hyg (2001) 1.74
Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. J Clin Invest (2009) 1.70
Nucleosome landscape and control of transcription in the human malaria parasite. Genome Res (2010) 1.70
Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis. J Exp Med (2008) 1.70
The malaria parasite Plasmodium falciparum histones: organization, expression, and acetylation. Gene (2006) 1.56
Cytokine expression in the brain in human cerebral malaria. J Infect Dis (1999) 1.54
Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum-infected erythrocytes to microvascular endothelial cells under flow. Blood (2000) 1.54
Structure and binding properties of monoclonal antibodies to core histones from autoimmune mice. Mol Immunol (1993) 1.51
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. J Immunol (2009) 1.48
Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium. Blood (2009) 1.46
Plasmodium falciparum--infected erythrocyte adhesion induces caspase activation and apoptosis in human endothelial cells. J Infect Dis (2003) 1.44
HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption. Microvasc Res (2010) 1.24
Antibodies against phosphatidylinositol and inositol monophosphate specifically inhibit tumour necrosis factor induction by malaria exoantigens. Immunology (1992) 1.23
Nucleosomes in serum as a marker for cell death. Clin Chem Lab Med (2001) 1.17
Plasmodium falciparum adhesion on human brain microvascular endothelial cells involves transmigration-like cup formation and induces opening of intercellular junctions. PLoS Pathog (2010) 1.16
Lung injury in uncomplicated and severe falciparum malaria: a longitudinal study in papua, Indonesia. J Infect Dis (2005) 1.14
Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis. Clin Pharmacol Ther (2002) 1.14
Nucleosomes in serum of patients with benign and malignant diseases. Int J Cancer (2001) 1.13
Soluble factors from Plasmodium falciparum-infected erythrocytes induce apoptosis in human brain vascular endothelial and neuroglia cells. Mol Biochem Parasitol (2008) 1.07
Src-family kinase dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins. Blood (2007) 1.07
Rho kinase inhibition in severe malaria: thwarting parasite-induced collateral damage to endothelia. J Infect Dis (2008) 1.06
Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: pathogenic or protective? Int J Parasitol (2007) 1.05
Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome. Eur J Immunol (2010) 1.04
The nucleosome (histone-DNA complex) is the TLR9-specific immunostimulatory component of Plasmodium falciparum that activates DCs. PLoS One (2011) 0.99
Plasmodium-induced inflammation by uric acid. PLoS Pathog (2008) 0.99
Glomerular immune deposits in murine lupus models may contain histones. Clin Exp Immunol (1992) 0.98
Host response to cytoadherence in Plasmodium falciparum. Biochem Soc Trans (2008) 0.97
Drotrecogin alfa (activated) in severe falciparum malaria. Anaesthesia (2006) 0.93
The histones of Plasmodium falciparum: identification, purification and a possible role in the pathology of malaria. Parasitology (1997) 0.93
Divergent roles of Toll-like receptor 2 in response to lipoteichoic acid and Staphylococcus aureus in vivo. Eur J Immunol (2010) 0.92
High mobility group box (HMGB) proteins of Plasmodium falciparum: DNA binding proteins with pro-inflammatory activity. Parasitol Int (2007) 0.92
The use of drotrecogin alfa in severe falciparum malaria. Anaesth Intensive Care (2010) 0.92
Metabolic acidosis induced by Plasmodium falciparum intraerythrocytic stages alters blood-brain barrier integrity. J Cereb Blood Flow Metab (2010) 0.91
The use of activated protein C in severe Plasmodium falciparum malaria. Anaesth Intensive Care (2007) 0.88
A moonlighting function of Plasmodium falciparum histone 3, mono-methylated at lysine 9? PLoS One (2010) 0.82
Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med (2009) 33.25
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 14.21
Typhoid fever. N Engl J Med (2002) 12.96
Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med (2014) 11.87
Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet (2012) 11.82
A metagenomic survey of microbes in honey bee colony collapse disorder. Science (2007) 11.72
Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A (2004) 8.95
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet (2010) 8.52
How clonal is Staphylococcus aureus? J Bacteriol (2003) 7.97
Extracellular histones are major mediators of death in sepsis. Nat Med (2009) 6.55
Artemisinin resistance: current status and scenarios for containment. Nat Rev Microbiol (2010) 6.28
Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A (2010) 5.69
The murine cerebral malaria phenomenon. Trends Parasitol (2009) 5.62
Hemofiltration and peritoneal dialysis in infection-associated acute renal failure in Vietnam. N Engl J Med (2002) 5.24
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nat Genet (2013) 5.22
Increasing incidence of human melioidosis in Northeast Thailand. Am J Trop Med Hyg (2010) 5.10
Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med (2005) 4.65
Virulent combinations of adhesin and toxin genes in natural populations of Staphylococcus aureus. Infect Immun (2002) 4.62
Intrahost modeling of artemisinin resistance in Plasmodium falciparum. Proc Natl Acad Sci U S A (2010) 4.50
Manslaughter by fake artesunate in Asia--will Africa be next? PLoS Med (2006) 4.46
Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. J Infect Dis (2007) 4.35
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
In vivo parasitological measures of artemisinin susceptibility. J Infect Dis (2010) 4.25
The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia. Malar J (2009) 4.25
Early origin and recent expansion of Plasmodium falciparum. Science (2003) 4.07
Counterfeit anti-infective drugs. Lancet Infect Dis (2006) 3.91
High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia. J Infect Dis (2010) 3.81
The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. PLoS Pathog (2008) 3.79
The WHO dengue classification and case definitions: time for a reassessment. Lancet (2006) 3.69
A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites. Mol Biol Evol (2003) 3.67
Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. PLoS Med (2007) 3.63
Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway. Cell (2013) 3.49
Diagnostic accuracy of NS1 ELISA and lateral flow rapid tests for dengue sensitivity, specificity and relationship to viraemia and antibody responses. PLoS Negl Trop Dis (2009) 3.30
Differential prevalence of Plasmodium infections and cryptic Plasmodium knowlesi malaria in humans in Thailand. J Infect Dis (2009) 3.25
Scrub typhus serologic testing with the indirect immunofluorescence method as a diagnostic gold standard: a lack of consensus leads to a lot of confusion. Clin Infect Dis (2007) 3.23
Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally. J Infect Dis (2010) 3.21
Streptococcus suis meningitis in adults in Vietnam. Clin Infect Dis (2008) 3.18
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest (2012) 3.09
The relationship between age and the manifestations of and mortality associated with severe malaria. Clin Infect Dis (2008) 3.05
Evaluation of the Panbio dengue virus nonstructural 1 antigen detection and immunoglobulin M antibody enzyme-linked immunosorbent assays for the diagnosis of acute dengue infections in Laos. Diagn Microbiol Infect Dis (2007) 2.90
Clinical features of human influenza A (H5N1) infection in Vietnam: 2004-2006. Clin Infect Dis (2009) 2.89
Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. J Infect Dis (2007) 2.89
Spurious amplification of a Plasmodium vivax small-subunit RNA gene by use of primers currently used to detect P. knowlesi. J Clin Microbiol (2009) 2.85
Plasmodium vivax transmission: chances for control? Trends Parasitol (2004) 2.79
In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. Antimicrob Agents Chemother (2004) 2.77
Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones. Antimicrob Agents Chemother (2007) 2.73
Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)--associated tuberculous meningitis. Clin Infect Dis (2011) 2.70
Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance. Malar J (2009) 2.70
Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum. Antimicrob Agents Chemother (2010) 2.68
Clinical research in resource-limited settings: enhancing research capacity and working together to make trials less complicated. PLoS Negl Trop Dis (2010) 2.68
A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand. PLoS Negl Trop Dis (2007) 2.65
Transparent development of the WHO rapid advice guidelines. PLoS Med (2007) 2.57
Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription. BMC Genomics (2011) 2.53
Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs. Nat Genet (2010) 2.48
An ultrastructural study of the brain in fatal Plasmodium falciparum malaria. Am J Trop Med Hyg (2003) 2.47
Contrasting genetic structure in Plasmodium vivax populations from Asia and South America. Int J Parasitol (2007) 2.41
Spatio-temporal distribution of Plasmodium falciparum and p. Vivax malaria in Thailand. Am J Trop Med Hyg (2005) 2.41
Establishment of a human hepatocyte line that supports in vitro development of the exo-erythrocytic stages of the malaria parasites Plasmodium falciparum and P. vivax. Am J Trop Med Hyg (2006) 2.39
Stage-dependent production and release of histidine-rich protein 2 by Plasmodium falciparum. Trans R Soc Trop Med Hyg (2005) 2.38
Guidelines for field surveys of the quality of medicines: a proposal. PLoS Med (2009) 2.36
Nonrandom distribution of Burkholderia pseudomallei clones in relation to geographical location and virulence. J Clin Microbiol (2006) 2.34
Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. J Innate Immun (2010) 2.34
The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infection. Clin Infect Dis (2006) 2.33
The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. Proc Natl Acad Sci U S A (2008) 2.33
Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis. J Infect Dis (2005) 2.29
Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe (2010) 2.28
Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin. Proc Natl Acad Sci U S A (2008) 2.19
Epidemiological factors associated with dengue shock syndrome and mortality in hospitalized dengue patients in Ho Chi Minh City, Vietnam. Am J Trop Med Hyg (2011) 2.17
Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria. Nature (2005) 2.17
Biological relevance of colony morphology and phenotypic switching by Burkholderia pseudomallei. J Bacteriol (2006) 2.16
The role of varroa mites in infections of Kashmir bee virus (KBV) and deformed wing virus (DWV) in honey bees. Virology (2005) 2.14
Risk factors for recurrent melioidosis in northeast Thailand. Clin Infect Dis (2006) 2.14
A prospective study of the causes of febrile illness requiring hospitalization in children in Cambodia. PLoS One (2013) 2.12
Spatial and temporal epidemiology of clinical malaria in Cambodia 2004-2013. Malar J (2014) 2.12
Liver involvement associated with dengue infection in adults in Vietnam. Am J Trop Med Hyg (2010) 2.10
Recurrent melioidosis in patients in northeast Thailand is frequently due to reinfection rather than relapse. J Clin Microbiol (2005) 2.09
Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses. J Immunol (2010) 2.09
Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J Immunol (2011) 2.09
Patient and sample-related factors that effect the success of in vitro isolation of Orientia tsutsugamushi. Southeast Asian J Trop Med Public Health (2007) 2.02
The first Plasmodium vivax relapses of life are usually genetically homologous. J Infect Dis (2011) 2.02
Randomized controlled comparison of ofloxacin, azithromycin, and an ofloxacin-azithromycin combination for treatment of multidrug-resistant and nalidixic acid-resistant typhoid fever. Antimicrob Agents Chemother (2006) 2.01
Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. J Infect Dis (2006) 1.99
Rapid immunofluorescence microscopy for diagnosis of melioidosis. Clin Diagn Lab Immunol (2005) 1.99
Characterization of novel LPXTG-containing proteins of Staphylococcus aureus identified from genome sequences. Microbiology (2003) 1.98
Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol (2011) 1.97
Kinetics of neutralizing antibodies in patients naturally infected by H5N1 virus. PLoS One (2010) 1.96
Unidentified acids of strong prognostic significance in severe malaria. Crit Care Med (2004) 1.95
Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein. PLoS Med (2007) 1.95
Pretreatment intracerebral and peripheral blood immune responses in Vietnamese adults with tuberculous meningitis: diagnostic value and relationship to disease severity and outcome. J Immunol (2006) 1.92
Doxycycline versus azithromycin for treatment of leptospirosis and scrub typhus. Antimicrob Agents Chemother (2007) 1.92
Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia. Clin Infect Dis (2005) 1.92
Fool's gold: Why imperfect reference tests are undermining the evaluation of novel diagnostics: a reevaluation of 5 diagnostic tests for leptospirosis. Clin Infect Dis (2012) 1.91
Avian influenza A (H5N1). J Clin Virol (2005) 1.90
Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis. J Clin Microbiol (2008) 1.89