Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 26230488)

Published in Transcription on August 08, 2015

Authors

Cristina Hernández-Munain1

Author Affiliations

1: a Department of Cellular Biology and Immunology ; Instituto de Parasitología y Biomedicina López-Neyra (IPBLN-CSIC); Parque Tecnológico de Ciencias de la Salud (PTS) ; Armilla , Granada , Spain.

Articles cited by this

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med (2004) 4.00

Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol (2008) 3.57

Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus. Immunity (2006) 3.39

Molecular genetics of T cell development. Annu Rev Immunol (2005) 3.26

A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58

Function of the TCR alpha enhancer in alphabeta and gammadelta T cells. Immunity (1997) 2.51

New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med (2005) 2.44

H3K4 tri-methylation provides an epigenetic signature of active enhancers. EMBO J (2011) 2.38

Regulation of T cell receptor-alpha gene recombination by transcription. Nat Immunol (2006) 2.29

Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J Immunol (2004) 2.18

The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity (2012) 2.15

A T cell-specific transcriptional enhancer within the human T cell receptor delta locus. Science (1990) 2.09

Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc Natl Acad Sci U S A (1998) 2.02

The selection and function of cell type-specific enhancers. Nat Rev Mol Cell Biol (2015) 1.93

Comparative genomics of the human and mouse T cell receptor loci. Immunity (2001) 1.92

Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol (2004) 1.91

Accessibility control of V(D)J recombination. Adv Immunol (2006) 1.87

Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors. Mol Cell Biol (1994) 1.81

Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): implications for TCR alpha locus accessibility. Immunity (1996) 1.70

Visualization of the earliest steps of gammadelta T cell development in the adult thymus. Nat Immunol (2006) 1.64

The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. Genomics (1994) 1.60

IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection. Nat Immunol (2015) 1.53

Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus. Immunol Rev (2004) 1.53

Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer. Mol Cell Biol (1991) 1.50

T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol (2003) 1.49

Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J (2007) 1.46

Regulation of the human T-cell receptor alpha gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements. Mol Cell Biol (1990) 1.42

Transcription factor expression dynamics of early T-lymphocyte specification and commitment. Dev Biol (2008) 1.42

Characterization of TCR gene rearrangements during adult murine T cell development. J Immunol (1999) 1.39

Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes. Proc Natl Acad Sci U S A (1998) 1.37

A locus control region in the T cell receptor alpha/delta locus. Immunity (1994) 1.37

TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression. Cancer Cell (2012) 1.36

c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer. Mol Cell Biol (1995) 1.33

Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers. J Exp Med (1994) 1.26

Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. Nat Immunol (2005) 1.22

Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure. J Exp Med (2005) 1.21

A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation. Immunity (1999) 1.17

Transcription of T cell antigen receptor genes is induced by protein kinase C activation. J Immunol (1988) 1.16

Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer. Immunity (1999) 1.13

Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination. Proc Natl Acad Sci U S A (2007) 1.11

Induction of T-cell receptor-alpha and -beta mRNA in SL12 cells can occur by transcriptional and post-transcriptional mechanisms. EMBO J (1988) 1.10

The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus. Proc Natl Acad Sci U S A (2004) 1.08

Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo. Mol Cell Biol (1998) 1.06

Signal- and development-dependent alternative splicing of LEF1 in T cells is controlled by CELF2. Mol Cell Biol (2011) 1.06

Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub. Proc Natl Acad Sci U S A (2012) 1.05

T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proc Natl Acad Sci U S A (2003) 0.99

Transferrin receptor expression as a marker of immature cycling thymocytes in the mouse. Cell Immunol (1994) 0.99

Early TCRalpha expression generates TCRalphagamma complexes that signal the DN-to-DP transition and impair development. Nat Immunol (2002) 0.98

Regulation of T cell receptor delta gene rearrangement by c-Myb. J Exp Med (1996) 0.96

Antagonistic effects of calcium ionophores and phorbol esters on T cell receptor mRNA levels in human thymocytes. J Immunol (1988) 0.95

Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancer. J Exp Med (1997) 0.95

c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells. Mol Cell Biol (2000) 0.95

Regulation of antigen receptor gene assembly by genetic-epigenetic crosstalk. Semin Immunol (2010) 0.95

TCRalpha enhancer activation occurs via a conformational change of a pre-assembled nucleo-protein complex. EMBO J (2000) 0.94

Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development. Immunol Res (2011) 0.93

The role of c-Myb or a related factor in regulating the T cell receptor gamma gene enhancer. J Immunol (1995) 0.92

Characterization of an avian (Gallus gallus domesticus) TCR alpha delta gene locus. J Immunol (1999) 0.91

GATA-3 dose-dependent checkpoints in early T cell commitment. J Immunol (2014) 0.89

Developmental activation of the TCR alpha enhancer requires functional collaboration among proteins bound inside and outside the core enhancer. J Immunol (2004) 0.89

Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2. J Exp Med (1997) 0.87

Long-distance regulation of fetal V(δ) gene segment TRDV4 by the Tcrd enhancer. J Immunol (2011) 0.87

Conservation of the T-cell receptor alpha/delta linkage in the teleost fish Tetraodon nigroviridis. Genomics (2002) 0.86

Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. J Immunol (2002) 0.86

TCRgamma silencing during alphabeta T cell development depends upon pre-TCR-induced proliferation. J Immunol (2006) 0.84

Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. PLoS One (2011) 0.83

Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination. Proc Natl Acad Sci U S A (1999) 0.82

Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling. J Immunol (2012) 0.82

Chromatin regulation by RUNX1. Blood Cells Mol Dis (2010) 0.82

Flexible stereospecific interactions and composition within nucleoprotein complexes assembled on the TCR alpha gene enhancer. J Immunol (2009) 0.81

T-cell receptor α enhancer is inactivated in αβ T lymphocytes. Proc Natl Acad Sci U S A (2015) 0.81

TcR-alpha mRNA accumulation does not dictate cell surface TcR/CD3 expression. Mol Immunol (1992) 0.81

Chromosomal excision of TCRdelta chain genes is dispensable for alphabeta T cell lineage commitment. Int Immunol (2005) 0.80

Coordinate transcriptional regulation of alpha and delta chains of the T-cell antigen receptors by phorbol esters and cyclic adenosine 5'-monophosphate in human thymocytes. J Biol Chem (1988) 0.79

Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters. J Immunol (2014) 0.78

The pre-TCR signal induces transcriptional silencing of the TCRγ locus by reducing the recruitment of STAT5 and Runx to transcriptional enhancers. Int Immunol (2011) 0.78