Published in Proc Natl Acad Sci U S A on November 19, 2012
CTCF: an architectural protein bridging genome topology and function. Nat Rev Genet (2014) 3.64
Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments. Genome Res (2013) 2.05
Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. J Exp Med (2014) 1.59
IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection. Nat Immunol (2015) 1.53
Architectural proteins: regulators of 3D genome organization in cell fate. Trends Cell Biol (2014) 1.12
Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies. J Immunol (2013) 0.98
Unifying model for molecular determinants of the preselection Vβ repertoire. Proc Natl Acad Sci U S A (2013) 0.95
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A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires. Nat Immunol (2015) 0.82
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An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments. J Immunol (2016) 0.77
The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements. Epigenetics Chromatin (2016) 0.77
Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development. J Immunol (2015) 0.77
Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53. J Immunol (2016) 0.76
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Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases. Front Immunol (2017) 0.75
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High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell (1992) 17.50
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
CTCF: master weaver of the genome. Cell (2009) 15.09
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature (2008) 10.95
Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell (2008) 7.80
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
CTCF-mediated functional chromatin interactome in pluripotent cells. Nat Genet (2011) 6.55
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32
Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nat Protoc (2007) 6.28
Cohesin: its roles and mechanisms. Annu Rev Genet (2009) 6.19
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
The beta-globin nuclear compartment in development and erythroid differentiation. Nat Genet (2003) 5.54
Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science (2002) 5.47
CTCF physically links cohesin to chromatin. Proc Natl Acad Sci U S A (2008) 4.89
The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions. Cell (2008) 3.92
The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell (2010) 3.88
Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. Genes Dev (2004) 3.66
Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev (1993) 3.63
Recombination centres and the orchestration of V(D)J recombination. Nat Rev Immunol (2011) 3.12
Genetics and epigenetics of the multifunctional protein CTCF. Curr Top Dev Biol (2008) 3.01
Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene. Nat Immunol (2004) 2.90
CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62
A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58
Function of the TCR alpha enhancer in alphabeta and gammadelta T cells. Immunity (1997) 2.51
The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. J Exp Med (2008) 2.50
The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells. Immunity (2011) 2.41
Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells. Genes Dev (2005) 2.39
Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol (1994) 2.38
Analysis of the H19ICR insulator. Mol Cell Biol (2007) 2.29
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity (2009) 2.24
CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. Mol Cell Biol (2008) 2.24
CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci U S A (2011) 2.23
Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development. J Immunol (2009) 2.20
Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus. Cell (2011) 1.94
CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators. Nucleic Acids Res (2007) 1.89
CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression. Int Immunol (1994) 1.89
Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes. Nat Immunol (2007) 1.77
Chromatin architecture and the generation of antigen receptor diversity. Cell (2009) 1.59
The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus. Immunity (2011) 1.57
CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J (2008) 1.55
Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J (2007) 1.46
Biochemistry of V(D)J recombination. Curr Top Microbiol Immunol (2005) 1.25
Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. Nat Immunol (2005) 1.22
Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure. J Exp Med (2005) 1.21
Enhancer control of local accessibility to V(D)J recombinase. Mol Cell Biol (1997) 1.12
Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination. J Exp Med (2010) 1.04
A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location. J Immunol (2011) 1.03
A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus. J Immunol (2011) 0.91
Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization. Immunol Res (2011) 0.91
Long-distance regulation of fetal V(δ) gene segment TRDV4 by the Tcrd enhancer. J Immunol (2011) 0.87
Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement. Trends Immunol (2012) 0.87
Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling. J Immunol (2012) 0.82
CTCF-cohesin complex: architect of chromatin structure regulates V(D)J rearrangement. Cell Res (2011) 0.81
Identification of ALK as a major familial neuroblastoma predisposition gene. Nature (2008) 7.38
Statistical analysis strategies for association studies involving rare variants. Nat Rev Genet (2010) 6.79
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32
Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein). J Neurosci (2003) 4.72
Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. Dev Cell (2007) 4.17
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature (2010) 4.16
CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. J Cell Biol (2005) 3.54
CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta. Dev Cell (2006) 2.99
Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol (2002) 2.75
LIS1, CLIP-170's key to the dynein/dynactin pathway. Mol Cell Biol (2002) 2.61
A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat Immunol (2002) 2.46
Cytoplasmic linker proteins promote microtubule rescue in vivo. J Cell Biol (2002) 2.38
Regulation of T cell receptor-alpha gene recombination by transcription. Nat Immunol (2006) 2.29
The importance of phase information for human genomics. Nat Rev Genet (2011) 2.25
Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends. J Cell Biol (2006) 2.25
CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci U S A (2011) 2.23
Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development. J Immunol (2009) 2.20
Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood (2008) 2.20
EB1 and EB3 control CLIP dissociation from the ends of growing microtubules. Mol Biol Cell (2005) 2.19
Kinase mutations in human disease: interpreting genotype-phenotype relationships. Nat Rev Genet (2010) 2.14
Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. J Cell Biol (2004) 2.12
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet (2013) 2.08
Particle filtering for multiple object tracking in dynamic fluorescence microscopy images: application to microtubule growth analysis. IEEE Trans Med Imaging (2008) 2.03
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol (2014) 1.95
Targeted inhibition of V(D)J recombination by a histone methyltransferase. Nat Immunol (2004) 1.84
Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. EMBO J (2008) 1.81
Role of CLASP2 in microtubule stabilization and the regulation of persistent motility. Curr Biol (2006) 1.81
Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice. Nat Genet (2002) 1.81
CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin. EMBO J (2005) 1.81
Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments. Nat Immunol (2008) 1.78
Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood (2005) 1.76
Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on microtubule plus ends. J Cell Biol (2008) 1.68
Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport. EMBO J (2003) 1.65
Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol (2006) 1.63
The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus. Immunity (2011) 1.57
Efficient and sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabet. Proc Natl Acad Sci U S A (2012) 1.57
CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J (2008) 1.55
CLIP-170 facilitates the formation of kinetochore-microtubule attachments. EMBO J (2005) 1.47
Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia. Ann Neurol (2014) 1.47
Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J (2007) 1.46
Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. J Cell Sci (2009) 1.46
Altered DNA methylation in leukocytes with trisomy 21. PLoS Genet (2010) 1.44
Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway. J Cell Sci (2008) 1.39
Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility. Proc Natl Acad Sci U S A (2002) 1.37
Repertoire-based selection into the marginal zone compartment during B cell development. J Exp Med (2008) 1.36
Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux. Curr Biol (2009) 1.34
The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Genes Dev (2005) 1.33
Functional analysis of CTCF during mammalian limb development. Dev Cell (2010) 1.33
Reshaping antibody diversity. Cell (2013) 1.32
CTCF is required for neural development and stochastic expression of clustered Pcdh genes in neurons. Cell Rep (2012) 1.27
Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. Mol Biol Cell (2006) 1.26
Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination. J Exp Med (2010) 1.23
Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes. Nat Immunol (2006) 1.23
Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes. Semin Immunol (2010) 1.23
Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. Nat Immunol (2005) 1.22
Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure. J Exp Med (2005) 1.21
Differential effects of matrix and growth factors on endothelial and fibroblast motility: application of a modified cell migration assay. J Cell Biochem (2006) 1.20
Microtubule-binding proteins CLASP1 and CLASP2 interact with actin filaments. Cell Motil Cytoskeleton (2007) 1.19
The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. Immunity (2012) 1.19
Regulation of the B cell receptor repertoire and self-reactivity by BAFF. J Immunol (2010) 1.19
A change in the structure of Vbeta chromatin associated with TCR beta allelic exclusion. J Immunol (2002) 1.18
Turning T-cell receptor beta recombination on and off: more questions than answers. Immunol Rev (2006) 1.16
T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. Blood (2006) 1.15
Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells. Proc Natl Acad Sci U S A (2012) 1.14
Sequence and structure signatures of cancer mutation hotspots in protein kinases. PLoS One (2009) 1.14
Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression. J Immunol (2009) 1.14
Germline transcription: a key regulator of accessibility and recombination. Adv Exp Med Biol (2009) 1.12
LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome. Bioessays (2004) 1.11
Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination. Proc Natl Acad Sci U S A (2007) 1.11
Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation. J Immunol (2005) 1.10
Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression. Proc Natl Acad Sci U S A (2010) 1.09
Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. J Immunol (2007) 1.08
Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5. Proc Natl Acad Sci U S A (2008) 1.08
The pathogen Candida albicans hijacks pyroptosis for escape from macrophages. MBio (2014) 1.07
CTCF regulates the local epigenetic state of ribosomal DNA repeats. Epigenetics Chromatin (2010) 1.06
Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. Nat Immunol (2005) 1.06
History-dependent catastrophes regulate axonal microtubule behavior. Curr Biol (2010) 1.05
Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination. J Exp Med (2010) 1.04
Mammalian Navigators are microtubule plus-end tracking proteins that can reorganize the cytoskeleton to induce neurite-like extensions. Cell Motil Cytoskeleton (2009) 1.03
An application and empirical comparison of statistical analysis methods for associating rare variants to a complex phenotype. Pac Symp Biocomput (2011) 1.02
Whole genome sequences of a male and female supercentenarian, ages greater than 114 years. Front Genet (2012) 1.01
The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling. J Immunol (2009) 1.01
The extent of histone acetylation correlates with the differential rearrangement frequency of individual VH genes in pro-B cells. J Immunol (2005) 1.01
Rao-Blackwellized marginal particle filtering for multiple object tracking in molecular bioimaging. Inf Process Med Imaging (2007) 1.01
High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes. J Immunol (2002) 1.01
Application of microdroplet PCR for large-scale targeted bisulfite sequencing. Genome Res (2011) 1.01
MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells. EMBO J (2013) 1.00
Cryo electron tomography of vitrified fibroblasts: microtubule plus ends in situ. J Struct Biol (2007) 0.99
Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing. J Immunol (2012) 0.98
Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies. J Immunol (2013) 0.98
Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo. J Immunol (2010) 0.98
Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus. J Immunol (2012) 0.97