Published in Nat Immunol on June 13, 2004
Launching the T-cell-lineage developmental programme. Nat Rev Immunol (2008) 3.86
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol (2009) 2.43
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev (2011) 2.38
The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells. Blood (2008) 2.34
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol (2008) 2.29
From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation. Immunol Rev (2010) 1.60
c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood (2010) 1.55
miR-150 regulates the development of NK and iNKT cells. J Exp Med (2011) 1.53
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. J Clin Invest (2010) 1.52
Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation. Proc Natl Acad Sci U S A (2009) 1.48
Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development. EMBO J (2011) 1.41
c-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood (2006) 1.39
Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med (2007) 1.37
Requirement of c-myb in T cell development and in mature T cell function. Proc Natl Acad Sci U S A (2004) 1.32
c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. EMBO J (2007) 1.27
c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression. Mol Cell Biol (2007) 1.26
The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage. Nat Immunol (2010) 1.25
Transcriptional control of invariant NKT cell development. Immunol Rev (2010) 1.24
CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. J Immunol (2009) 1.21
Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development (2013) 1.17
c-Myb is required for pro-B cell differentiation. J Immunol (2009) 1.10
The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Mol Biol Cell (2005) 1.07
c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL. J Immunol (2010) 1.05
A B-Myb complex containing clathrin and filamin is required for mitotic spindle function. EMBO J (2008) 1.05
Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities. Mol Cell Biol (2008) 1.04
Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis. Blood (2008) 1.04
Transcriptional control of early T and B cell developmental choices. Annu Rev Immunol (2014) 1.03
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. J Biol Chem (2008) 1.03
MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia. Leukemia (2014) 1.02
Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis. EMBO J (2009) 1.00
Regulation of cyst wall protein promoters by Myb2 in Giardia lamblia. J Biol Chem (2008) 0.96
MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas. Acta Neuropathol (2010) 0.96
TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation. Mol Biol Cell (2005) 0.95
Potential tumor suppressor role for the c-Myb oncogene in luminal breast cancer. PLoS One (2010) 0.95
Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies. Mol Cell Biol (2014) 0.94
Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation. Cell Cycle (2013) 0.93
Batf promotes growth arrest and terminal differentiation of mouse myeloid leukemia cells. Mol Cancer Res (2011) 0.93
Identification of c-Myb Target Genes in K562 Cells Reveals a Role for c-Myb as a Master Regulator. Genes Cancer (2011) 0.89
From murine to human nude/SCID: the thymus, T-cell development and the missing link. Clin Dev Immunol (2012) 0.89
c-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed lineage leukemia (MLL) for histone modification of the IL-13 locus. J Immunol (2011) 0.87
MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation, differentiation, and development. Crit Rev Immunol (2013) 0.87
T-lineage cells require the thymus but not VDJ recombination to produce IL-17A and regulate granulopoiesis in vivo. J Immunol (2009) 0.87
Regulation of GATA-3 expression during CD4 lineage differentiation. J Immunol (2011) 0.86
Eliciting the T cell fate with Notch. Semin Immunol (2010) 0.86
Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis. Cancers (Basel) (2014) 0.85
B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development. Proc Natl Acad Sci U S A (2014) 0.83
Transcription factor network regulating CD(+)CD8(+) thymocyte survival. Crit Rev Immunol (2011) 0.82
The C-MYB story--is it definitive? Proc Natl Acad Sci U S A (2010) 0.82
Progress in multiple sclerosis genetics. Curr Genomics (2012) 0.81
The enigma of CD4-lineage specification. Eur J Immunol (2011) 0.81
Myb proteins regulate expression of histone variant H2A.Z during thymocyte development. Immunology (2007) 0.81
Duplication and maintenance of the Myb genes of vertebrate animals. Biol Open (2012) 0.80
miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Sci Rep (2016) 0.79
Myb expression is critical for myeloid leukemia development induced by Setbp1 activation. Oncotarget (2016) 0.78
A degradation-resistant c-Myb mutant cooperates with Bcl-2 in enhancing proliferative potential and survival of hematopoietic cells. Blood Cells Mol Dis (2007) 0.78
Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes. Transcription (2015) 0.78
Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells. PLoS One (2015) 0.77
c-Myb regulates cell cycle-dependent expression of Erbin: an implication for a novel function of Erbin. PLoS One (2012) 0.77
p89c-Myb is not required for fetal or adult hematopoiesis. Genesis (2010) 0.77
Transcriptional control of CD4 and CD8 coreceptor expression during T cell development. Cell Mol Life Sci (2013) 0.76
T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. PLoS One (2014) 0.75
c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia (2016) 0.75
Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia. Cancer Discov (2016) 0.75
BAP31 is involved in T cell activation through TCR signal pathways. Sci Rep (2017) 0.75
miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb. Cell Rep (2017) 0.75
Regulation of the germinal center response by microRNA-155. Science (2007) 12.25
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol (2008) 10.42
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell (2007) 9.33
MicroRNA control in the immune system: basic principles. Cell (2009) 7.16
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06
Aberrant T cell differentiation in the absence of Dicer. J Exp Med (2005) 6.58
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol (2006) 5.70
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53
Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science (2006) 5.31
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity (2009) 5.10
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci (2005) 4.44
PI3 kinase signals BCR-dependent mature B cell survival. Cell (2009) 4.43
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell (2004) 4.31
Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity (2006) 3.74
Vagaries of conditional gene targeting. Nat Immunol (2007) 3.51
Selective erasure of a fear memory. Science (2009) 3.34
Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature (2002) 3.21
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell (2012) 3.10
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A (2011) 3.07
Yin Yang 1 is a critical regulator of B-cell development. Genes Dev (2007) 3.06
B cell receptor signal strength determines B cell fate. Nat Immunol (2004) 3.06
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes. Proc Natl Acad Sci U S A (2002) 3.01
Rapid generation of inducible mouse mutants. Nucleic Acids Res (2003) 2.77
BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma. Cancer Cell (2010) 2.73
Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS One (2008) 2.69
Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest (2003) 2.66
D2R striatopallidal neurons inhibit both locomotor and drug reward processes. Nat Neurosci (2009) 2.65
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol (2007) 2.60
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med (2004) 2.58
TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol (2004) 2.51
Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell (2012) 2.50
Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol (2008) 2.50
High-resolution description of antibody heavy-chain repertoires in humans. PLoS One (2011) 2.36
B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity (2007) 2.28
Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27
Mature T cells depend on signaling through the IKK complex. Immunity (2003) 2.21
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest (2005) 2.20
Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors. Sci Transl Med (2010) 2.13
FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. Immunity (2006) 2.10
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A (2004) 2.09
The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia. Cancer Cell (2010) 2.09
Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res (2002) 2.03
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. EMBO J (2013) 2.01
IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med (2002) 1.93
Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood (2002) 1.91
c-Myb is critical for B cell development and maintenance of follicular B cells. Immunity (2005) 1.87
Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma. Cancer Cell (2010) 1.85
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol (2012) 1.82
Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci U S A (2004) 1.80
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice. Eur J Immunol (2002) 1.79
Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. J Clin Invest (2004) 1.79
Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A (2006) 1.78
Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity (2008) 1.77
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J Exp Med (2007) 1.75
Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo. J Immunol (2009) 1.69
Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol (2007) 1.68
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J Exp Med (2012) 1.61
Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell (2012) 1.59
T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med (2004) 1.55
Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. Cell Metab (2008) 1.49
Basal immunoglobulin signaling actively maintains developmental stage in immature B cells. PLoS Biol (2005) 1.47
NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells. Proc Natl Acad Sci U S A (2008) 1.47
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med (2008) 1.47
Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J (2008) 1.47
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med (2005) 1.46
Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs. J Clin Invest (2008) 1.44
Pillars article: a critical role of lambda 5 protein in B cell development. Cell. 1992. 69: 823-831. J Immunol (2010) 1.43
The lingering enigma of the allelic exclusion mechanism. Cell (2004) 1.42
Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. J Exp Med (2009) 1.40
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. J Clin Invest (2012) 1.40
Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol (2005) 1.37
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. J Exp Med (2006) 1.36
NONO couples the circadian clock to the cell cycle. Proc Natl Acad Sci U S A (2012) 1.34
Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol (2005) 1.34
Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. J Exp Med (2008) 1.34
Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen. Proc Natl Acad Sci U S A (2008) 1.32
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells. Proc Natl Acad Sci U S A (2008) 1.29
Generation of mice with a conditional Foxp2 null allele. Genesis (2007) 1.27
Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction. Proc Natl Acad Sci U S A (2003) 1.26
Incomplete block of B cell development and immunoglobulin production in mice carrying the muMT mutation on the BALB/c background. Eur J Immunol (2002) 1.24
Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. J Exp Med (2011) 1.24
B cells are crucial for both development and maintenance of the splenic marginal zone. J Immunol (2004) 1.23
Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. Hum Mol Genet (2006) 1.22
Antibody repertoires generated by VH replacement and direct VH to JH joining. Immunity (2006) 1.21
Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood (2009) 1.21
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification. Nat Biotechnol (2009) 1.21
Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. J Clin Invest (2011) 1.20
The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain. Immunity (2006) 1.19
Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing. Hum Mol Genet (2010) 1.19
Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals. Nat Immunol (2009) 1.19
TET proteins and 5-methylcytosine oxidation in hematological cancers. Immunol Rev (2015) 1.18