Published in Front Mol Neurosci on July 14, 2015
Na(+)/H(+) Exchanger 9 Regulates Iron Mobilization at the Blood-Brain Barrier in Response to Iron Starvation. J Biol Chem (2017) 0.75
Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov (2017) 0.75
Transport of Non-Transferrin Bound Iron to the Brain: Implications for Alzheimer's Disease. J Alzheimers Dis (2017) 0.75
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 19.19
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (1999) 13.19
Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci (2006) 12.23
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature (2000) 7.46
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab (2005) 5.32
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell (2000) 5.31
A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem (2000) 5.21
Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. Science (1988) 4.86
Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci U S A (1998) 4.07
Hepcidin and iron regulation, 10 years later. Blood (2011) 3.80
Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet (1999) 3.30
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet (2005) 3.28
Hepcidin and iron homeostasis. Biochim Biophys Acta (2012) 2.96
An iron-regulated ferric reductase associated with the absorption of dietary iron. Science (2001) 2.90
IL-1 stimulates IL-6 production in endothelial cells. J Immunol (1989) 2.85
Stoichiometric and site characteristics of the binding of iron to human transferrin. J Biol Chem (1978) 2.63
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood (2007) 2.51
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell (2010) 2.46
A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression. Cell Metab (2009) 2.10
A cytosolic iron chaperone that delivers iron to ferritin. Science (2008) 2.00
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem (2002) 2.00
Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proc Natl Acad Sci U S A (2004) 1.97
Iron deficiency alters brain development and functioning. J Nutr (2003) 1.93
Oligodendrocytes and myelination: the role of iron. Glia (2009) 1.90
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J Neuroinflammation (2014) 1.83
Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology (2000) 1.75
Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition. J Neurosci (2011) 1.66
Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci U S A (1999) 1.66
Vacuolar and plasma membrane proton-adenosinetriphosphatases. Physiol Rev (1999) 1.61
Chaperone protein involved in transmembrane transport of iron. Biochem J (2014) 1.52
Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Invest Ophthalmol Vis Sci (2008) 1.47
Iron metabolism in the CNS: implications for neurodegenerative diseases. Nat Rev Neurosci (2013) 1.46
CSF iron, ferritin and transferrin levels in restless legs syndrome. J Sleep Res (2005) 1.46
Molecular bases of cellular iron toxicity. Free Radic Biol Med (2002) 1.44
Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis. J Alzheimers Dis (2009) 1.43
Mammalian iron transport. Cell Mol Life Sci (2009) 1.42
Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption. Biochem Soc Trans (2002) 1.40
Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res (2001) 1.38
Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem (2010) 1.37
Redox-active iron mediates amyloid-beta toxicity. Free Radic Biol Med (2001) 1.35
Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci (2011) 1.32
Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res (2004) 1.32
The role of metallobiology and amyloid-β peptides in Alzheimer's disease. J Neurochem (2011) 1.31
Metal dyshomeostasis and oxidative stress in Alzheimer's disease. Neurochem Int (2012) 1.29
The rat blood-brain barrier transcriptome. J Cereb Blood Flow Metab (2005) 1.23
Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. J Neurosci Res (2002) 1.18
Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells. J Neurochem (2013) 1.15
Brain iron toxicity: differential responses of astrocytes, neurons, and endothelial cells. Neurochem Res (2007) 1.13
Cellular iron: ferroportin is the only way out. Cell Metab (2005) 1.13
Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6. Ann N Y Acad Sci (1989) 1.12
The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood (2000) 1.12
The family of iron responsive RNA structures regulated by changes in cellular iron and oxygen. Cell Mol Life Sci (2007) 1.09
The amyloid precursor protein: a biochemical enigma in brain development, function and disease. FEBS Lett (2013) 1.07
The unique kinetics of iron release from transferrin: the role of receptor, lobe-lobe interactions, and salt at endosomal pH. J Mol Biol (2009) 1.07
Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches. Front Cell Neurosci (2014) 1.06
Cellular and mitochondrial iron homeostasis in vertebrates. Biochim Biophys Acta (2012) 1.05
Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin. J Biol Inorg Chem (2010) 1.03
Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells. J Cell Biochem (2007) 1.02
Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats. Eur J Neurosci (2007) 1.01
Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochim Biophys Acta (2008) 1.01
Mitochondrial iron metabolism and its role in neurodegeneration. J Alzheimers Dis (2010) 1.01
The role of iron in mitochondrial function. Biochim Biophys Acta (2008) 1.00
P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells. Br J Pharmacol (2007) 0.99
Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease. Biochem Soc Trans (2008) 0.99
Role of hepcidin in murine brain iron metabolism. Cell Mol Life Sci (2009) 0.99
Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin. J Biol Chem (2013) 0.98
Role of iron in neurotoxicity: a cause for concern in the elderly? Curr Opin Clin Nutr Metab Care (2009) 0.98
Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase. Proc Natl Acad Sci U S A (2014) 0.96
The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption. Blood Cells Mol Dis (2003) 0.96
Iron efflux from oligodendrocytes is differentially regulated in gray and white matter. J Neurosci (2011) 0.96
Cellular and subcellular localizations of nonheme ferric and ferrous iron in the rat brain: a light and electron microscopic study by the perfusion-Perls and -Turnbull methods. Arch Histol Cytol (2008) 0.96
The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development (2010) 0.95
Pathophysiology of restless legs syndrome: evidence for iron involvement. Curr Neurol Neurosci Rep (2008) 0.94
Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1. J Neurochem (2006) 0.94
Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells. J Nutr (2010) 0.94
Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages. PLoS Pathog (2014) 0.93
Diurnal cycle influences peripheral and brain iron levels in mice. J Appl Physiol (1985) (2008) 0.93
sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin. EMBO Rep (2014) 0.93
Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity. Int J Biochem Cell Biol (2011) 0.92
Recycling kinetics and transcytosis of transferrin in primary cultures of bovine brain microvessel endothelial cells. J Cell Physiol (1991) 0.92
A novel model for brain iron uptake: introducing the concept of regulation. J Cereb Blood Flow Metab (2014) 0.91
Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells. PLoS One (2014) 0.90
Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux. J Biol Chem (2013) 0.90
Immunocompetence of human microvascular brain endothelial cells: cytokine regulation of IL-1beta, MCP-1, IL-10, sICAM-1 and sVCAM-1. J Neurol (1998) 0.90
Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis. Neurosci Lett (2004) 0.89
Development and iron-dependent expression of hephaestin in different brain regions of rats. J Cell Biochem (2007) 0.89
Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders. Front Pharmacol (2012) 0.89
Special delivery: distributing iron in the cytosol of mammalian cells. Front Pharmacol (2014) 0.88
Transient expression of iron transport proteins in the capillary of the developing rat brain. Cell Mol Neurobiol (2011) 0.86
Essential but toxic: controlling the flux of iron in the body. Clin Exp Pharmacol Physiol (2012) 0.86
Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade rats. Am J Physiol Gastrointest Liver Physiol (2000) 0.85
Interleukin-1β induces ceruloplasmin and ferroportin-1 gene expression via MAP kinases and C/EBPβ, AP-1, and NF-κB activation. Neurosci Lett (2010) 0.85
Quantitative measurement of alternatively spliced amyloid precursor protein mRNA expression in Alzheimer's disease and normal brain by S1 nuclease protection analysis. Neurobiol Aging (1992) 0.85
Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide β-amyloid. Inorg Chem (2014) 0.85
Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide β-amyloid (1-42). J R Soc Interface (2014) 0.85
Mechanistic analysis of iron accumulation by endothelial cells of the BBB. Biometals (2012) 0.84
Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism. Am J Physiol Cell Physiol (2002) 0.84
Human brain endothelial cells and astrocytes produce IL-1 beta but not IL-10. Scand J Immunol (1996) 0.84
Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons. J Neurochem (2015) 0.84
Role of brain iron accumulation in cognitive dysfunction: evidence from animal models and human studies. J Alzheimers Dis (2013) 0.84