Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis.

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Published in Proc Natl Acad Sci U S A on August 03, 2015

Authors

Daniel R Marous1, Evan P Lloyd2, Andrew R Buller3, Kristos A Moshos2, Tyler L Grove4, Anthony J Blaszczyk5, Squire J Booker6, Craig A Townsend7

Author Affiliations

1: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
2: Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218;
3: Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218;
4: Department of Chemistry, The Pennsylvania State University, University Park, PA 16802;
5: Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802.
6: Department of Chemistry, The Pennsylvania State University, University Park, PA 16802; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802.
7: Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218; ctownsend@jhu.edu.

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