Published in Mol Biol Cell on August 05, 2015
Calpain research for drug discovery: challenges and potential. Nat Rev Drug Discov (2016) 0.82
Regulation of invadopodia by mechanical signaling. Exp Cell Res (2015) 0.78
Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC. Oncol Lett (2017) 0.75
A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells. J Cell Sci (2017) 0.75
Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer. Cancer Sci (2016) 0.75
Fibronectin induces epithelial-mesenchymal transition in human breast cancer MCF-7 cells via activation of calpain. Oncol Lett (2017) 0.75
Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis. Mol Cell Biol (2016) 0.75
The clinical significance of the Ezrin gene and circulating tumor cells in osteosarcoma. Onco Targets Ther (2017) 0.75
Regulation of RhoA by STAT3 coordinates glial scar formation. J Cell Biol (2017) 0.75
NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia. Oncol Lett (2017) 0.75
Retrospective Proteomic Screening of 100 Breast Cancer Tissues. Proteomes (2017) 0.75
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31
ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol (2002) 8.41
Interplay between Rac and Rho in the control of substrate contact dynamics. Curr Biol (1999) 5.29
Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol (2009) 4.99
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J Cell Sci (2003) 4.85
Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol (2004) 4.29
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med (2004) 4.28
The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol (2007) 4.23
Assembly and mechanosensory function of focal contacts. Curr Opin Cell Biol (2001) 3.73
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci (2006) 3.71
Microtubule targeting of substrate contacts promotes their relaxation and dissociation. J Cell Biol (1999) 3.53
Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev Cell (2004) 3.33
Hierarchical assembly of cell-matrix adhesion complexes. Biochem Soc Trans (2004) 3.15
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators. Nat Med (2004) 2.90
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell (2011) 2.64
Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol (2004) 2.46
Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane. J Cell Biol (2000) 2.45
Cutting to the chase: calpain proteases in cell motility. Trends Cell Biol (2002) 2.38
Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway. J Biol Chem (2000) 2.37
Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases. J Cell Biol (2007) 2.31
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol (2008) 2.27
Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. Mol Cell (2000) 2.27
Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol Cell Biol (2000) 2.23
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. J Cell Biol (2009) 1.97
Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts. J Biol Chem (2001) 1.91
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. J Cell Biol (2008) 1.79
The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res (2005) 1.76
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J Biol Chem (2010) 1.75
FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth. EMBO J (2002) 1.55
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
Inhibition of calpain stabilises podosomes and impairs dendritic cell motility. J Cell Sci (2006) 1.47
Indirect association of ezrin with F-actin: isoform specificity and calcium sensitivity. J Cell Biol (1995) 1.45
Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells. Genes Cells (2003) 1.43
Ultrastructure and gold-immunolabelling of cell-substratum adhesions (podosomes) in RSV-transformed BHK cells. J Cell Sci (1989) 1.41
Paxillin phosphorylation controls invadopodia/podosomes spatiotemporal organization. Mol Biol Cell (2007) 1.39
Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42. Mol Biol Cell (2007) 1.36
Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain. Mol Cell Biol (2005) 1.35
Src-dependent ezrin phosphorylation in adhesion-mediated signaling. Mol Biol Cell (2005) 1.35
Expression of the cytoskeleton linker protein ezrin in human cancers. Clin Exp Metastasis (2007) 1.34
Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation. Mol Cell Biol (2006) 1.31
Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration. Mol Biol Cell (2005) 1.30
The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages. Mol Biol Cell (2006) 1.27
An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production. Circ Res (2008) 1.26
Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer. Hum Pathol (2008) 1.25
Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain. FEBS Lett (1999) 1.24
Dissecting the functional domain requirements of cortactin in invadopodia formation. Eur J Cell Biol (2007) 1.23
Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion. J Biol Chem (2001) 1.17
Asymmetric localization of calpain 2 during neutrophil chemotaxis. Mol Biol Cell (2006) 1.14
Ezrin-calpain I interactions in gastric parietal cells. Am J Physiol (1993) 1.13
Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas. Breast Cancer Res Treat (2006) 1.12
Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosis. J Cell Sci (2011) 1.08
Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas. Mod Pathol (2006) 1.08
Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression. PLoS One (2013) 1.08
m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2010) 1.07
Formation of extracellular matrix-digesting invadopodia by primary aortic smooth muscle cells. Circ Res (2007) 1.07
Ezrin mediates c-Myc actions in prostate cancer cell invasion. Oncogene (2009) 1.04
Co-operative effect of c-Src and ezrin in deregulation of cell-cell contacts and scattering of mammary carcinoma cells. J Cell Biochem (2004) 1.03
Quantitative and unbiased analysis of directional persistence in cell migration. Nat Protoc (2014) 1.02
Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions. Dev Cell (2012) 1.02
Pathological roles of invadopodia in cancer invasion and metastasis. Eur J Cell Biol (2012) 1.01
Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering. EMBO J (2007) 1.01
Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis. J Cell Biol (2014) 1.01
Leukocyte membrane "expansion": a central mechanism for leukocyte extravasation. J Leukoc Biol (2007) 0.97
LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence. J Biol Chem (2013) 0.92
Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells. BMC Cancer (2012) 0.92
The ezrin metastatic phenotype is associated with the initiation of protein translation. Neoplasia (2012) 0.89
Integrins in cell migration. Methods Enzymol (2007) 0.89
Expression of three calpain isoform genes in human skeletal muscles. J Neurol Sci (1998) 0.88
Nck enables directional cell migration through the coordination of polarized membrane protrusion with adhesion dynamics. J Cell Sci (2013) 0.86
Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas. J Clin Pathol (2011) 0.86
Src activation and translocation from focal adhesions to membrane ruffles contribute to formation of new adhesion sites. Cell Mol Life Sci (2009) 0.85
Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity. PLoS One (2012) 0.83