Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis.

PubWeight™: 1.54‹?› | Rank: Top 4%

🔗 View Article (PMC 3031464)

Published in Mol Biol Cell on February 01, 2011

Authors

Nicholas O Deakin1, Christopher E Turner

Author Affiliations

1: Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.

Articles citing this

Nonpolarized signaling reveals two distinct modes of 3D cell migration. J Cell Biol (2012) 2.76

At the leading edge of three-dimensional cell migration. J Cell Sci (2013) 1.66

Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. Am J Pathol (2012) 1.60

Cell-matrix adhesions in 3D. Matrix Biol (2011) 1.54

Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition. J Cell Biol (2012) 1.45

Dimensions in cell migration. Curr Opin Cell Biol (2013) 1.36

Adhesion dynamics at a glance. J Cell Sci (2011) 1.13

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. J Cell Biol (2013) 1.13

Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention. Adv Wound Care (New Rochelle) (2013) 1.10

FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration. Mol Biol Cell (2012) 1.08

Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration. J Cell Sci (2013) 1.06

Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis. J Cell Biol (2014) 1.01

Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition. PLoS One (2011) 1.00

Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. PLoS One (2012) 1.00

The structure of cell-matrix adhesions: the new frontier. Curr Opin Cell Biol (2011) 0.99

Critical role of miR-10b in transforming growth factor-β1-induced epithelial-mesenchymal transition in breast cancer. Cancer Gene Ther (2014) 0.99

Diverse roles for the paxillin family of proteins in cancer. Genes Cancer (2012) 0.98

Antitumor action of a novel histone deacetylase inhibitor, YF479, in breast cancer. Neoplasia (2014) 0.93

The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition. Sci Rep (2014) 0.92

Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner. Proc Natl Acad Sci U S A (2014) 0.87

Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion. Mol Biol Cell (2015) 0.87

Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration. J Cell Biol (2014) 0.86

Cost-benefit analysis of the mechanisms that enable migrating cells to sustain motility upon changes in matrix environments. J R Soc Interface (2015) 0.85

The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration. Mol Biol Cell (2012) 0.84

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces. Clin Exp Metastasis (2015) 0.83

Trading in your spindles for blebs: the amoeboid tumor cell phenotype in prostate cancer. Asian J Androl (2014) 0.83

The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis. PLoS One (2014) 0.83

Occupy tissue: the movement in cancer metastasis. Cell Adh Migr (2012) 0.83

LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One (2013) 0.83

Overlapping nongenomic and genomic actions of thyroid hormone and steroids. Best Pract Res Clin Endocrinol Metab (2015) 0.82

Dia-interacting protein (DIP) imposes migratory plasticity in mDia2-dependent tumor cells in three-dimensional matrices. PLoS One (2012) 0.82

Evolutionary game theory for physical and biological scientists. II. Population dynamics equations can be associated with interpretations. Interface Focus (2014) 0.82

Paxillin controls directional cell motility in response to physical cues. Cell Adh Migr (2012) 0.81

CdGAP regulates cell migration and adhesion dynamics in two-and three-dimensional matrix environments. Cytoskeleton (Hoboken) (2012) 0.80

MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells. Biochem J (2014) 0.80

Intracellular modifiers of integrin alpha 6p production in aggressive prostate and breast cancer cell lines. Biochem Biophys Res Commun (2014) 0.79

Hic-5 is required for myofibroblast differentiation by regulating mechanically dependent MRTF-A nuclear accumulation. J Cell Sci (2016) 0.79

Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway. Mol Cancer (2016) 0.79

Generalized principles of stochasticity can be used to control dynamic heterogeneity. Phys Biol (2012) 0.78

Nanoimaging of focal adhesion dynamics in 3D. PLoS One (2014) 0.78

Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis. Sci Rep (2015) 0.78

FAK and paxillin, two potential targets in pancreatic cancer. Oncotarget (2016) 0.78

Paxillin and steroid signaling: from frog to human. Methods Mol Biol (2014) 0.77

Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase. J Biol Chem (2015) 0.77

Mechanosensing via cell-matrix adhesions in 3D microenvironments. Exp Cell Res (2015) 0.77

VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells. Mol Cancer Res (2014) 0.77

N-ethylmaleimide-sensitive factor attachment protein α (αSNAP) regulates matrix adhesion and integrin processing in human epithelial cells. J Biol Chem (2013) 0.77

Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing. J Cell Biol (2014) 0.77

Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase. J Cell Sci (2016) 0.77

Automated analysis of cell-matrix adhesions in 2D and 3D environments. Sci Rep (2015) 0.76

Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes. J Cell Biol (2016) 0.76

Time-lapse imaging assay using the BioStation CT: a sensitive drug-screening method for three-dimensional cell culture. Cancer Sci (2015) 0.75

Hydrogen peroxide-inducible clone-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice. PLoS One (2015) 0.75

Integrins in development and cancer. Biophys Rev (2013) 0.75

Hic-5 remodeling of the stromal matrix promotes breast tumor progression. Oncogene (2016) 0.75

MiR-137: an important player in neural development and neoplastic transformation. Mol Psychiatry (2016) 0.75

Hydrogen peroxide inducible clone-5 mediates reactive oxygen species signaling for hepatocellular carcinoma progression. Oncotarget (2015) 0.75

Leupaxin is expressed in mammary carcinoma and acts as a transcriptional activator of the estrogen receptor α. Int J Oncol (2015) 0.75

Current status and perspectives in atomic force microscopy-based identification of cellular transformation. Int J Nanomedicine (2016) 0.75

The serum protein profile of early parity which induces protection against breast cancer. Oncotarget (2016) 0.75

Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells. FASEB J (2017) 0.75

Articles cited by this

Cell migration: integrating signals from front to back. Science (2003) 29.13

Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85

A multigenic program mediating breast cancer metastasis to bone. Cancer Cell (2003) 16.86

Taking cell-matrix adhesions to the third dimension. Science (2001) 15.21

Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer (2003) 13.01

Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science (2002) 12.29

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol (1996) 11.04

FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31

Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol (2003) 8.68

Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol (1999) 8.66

Genes that mediate breast cancer metastasis to the brain. Nature (2009) 8.23

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol (2003) 7.93

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol (2003) 7.89

Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28

X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell (2006) 7.17

Coordination of Rho GTPase activities during cell protrusion. Nature (2009) 6.54

Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med (2006) 6.44

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol (2007) 6.15

Rac activation and inactivation control plasticity of tumor cell movement. Cell (2008) 6.01

Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat Cell Biol (2008) 5.87

Plasticity of cell migration: a multiscale tuning model. J Cell Biol (2009) 5.82

Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer (2002) 5.57

Identification of molecular apocrine breast tumours by microarray analysis. Oncogene (2005) 5.27

Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol (2009) 4.99

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J Cell Sci (2003) 4.85

Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization. In Vitro (1978) 4.67

Lamellipodial actin mechanically links myosin activity with adhesion-site formation. Cell (2007) 4.59

Paxillin: adapting to change. Physiol Rev (2004) 4.48

A Rac switch regulates random versus directionally persistent cell migration. J Cell Biol (2005) 4.40

Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol (2009) 4.39

Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. Nat Cell Biol (2007) 4.26

Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem (2007) 3.87

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell (2007) 3.84

RhoA is required for monocyte tail retraction during transendothelial migration. J Cell Biol (2001) 3.79

Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell (2004) 3.73

A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci (2006) 3.71

Paxillin comes of age. J Cell Sci (2008) 3.57

ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol (2006) 3.55

A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro. J Bone Miner Res (2001) 3.43

Cell motility through plasma membrane blebbing. J Cell Biol (2008) 3.29

Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. BMC Cancer (2007) 3.16

The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol (2002) 2.73

Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment. Oncogene (2000) 2.71

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding. J Cell Biol (1996) 2.63

Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J Biol Chem (1995) 2.44

Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J Cell Biol (2007) 2.33

Asymmetric focal adhesion disassembly in motile cells. Curr Opin Cell Biol (2008) 2.28

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol (2008) 2.27

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK. J Exp Med (1995) 2.17

Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells. J Cell Biol (2000) 2.13

The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL). J Cell Biol (2001) 2.10

Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro. Cancer Res (1995) 1.92

Dissection of amoeboid movement into two mechanically distinct modes. J Cell Sci (2006) 1.90

Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J Cell Sci (2006) 1.83

The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer. Proc Natl Acad Sci U S A (2005) 1.80

Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J Cell Biol (2006) 1.76

DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol (2008) 1.75

Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. Oncogene (2006) 1.73

Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin. J Cell Sci (1999) 1.72

Fos-transformation activates genes associated with invasion. Oncogene (1994) 1.66

Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment. Clin Exp Metastasis (2008) 1.51

Force generated by actomyosin contraction builds bridges between adhesive contacts. EMBO J (2010) 1.47

Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis. Int J Cancer (2003) 1.41

EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style. Cancer Res (2009) 1.39

Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta. J Cell Sci (2005) 1.31

FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. J Cell Sci (2009) 1.29

Contractility modulates cell adhesion strengthening through focal adhesion kinase and assembly of vinculin-containing focal adhesions. J Cell Physiol (2010) 1.29

Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices. Methods Mol Biol (2009) 1.27

Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase. J Biol Chem (1998) 1.26

Hic-5 contributes to epithelial-mesenchymal transformation through a RhoA/ROCK-dependent pathway. J Cell Physiol (2007) 1.22

Uni-axial stretching regulates intracellular localization of Hic-5 expressed in smooth-muscle cells in vivo. J Cell Sci (2005) 1.20

Moesin orchestrates cortical polarity of melanoma tumour cells to initiate 3D invasion. J Cell Sci (2009) 1.18

Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase. Mol Cell Biol (2001) 1.15

Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. J Biol Chem (2004) 1.15

Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. Oncogene (2005) 1.10

Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly. Protein Sci (2005) 1.06

Different expression of androgen receptor coactivators in human prostate. Urology (2001) 1.05

An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. J Cell Sci (2009) 1.04

Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin. PLoS Biol (2009) 1.02

The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. J Cell Sci (2009) 1.01

MET, HGF, EGFR, and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples and prognostic significance. J Environ Pathol Toxicol Oncol (2009) 1.01

Cyclic strain promotes shuttling of PYK2/Hic-5 complex from focal contacts in osteoblast-like cells. Biochem Biophys Res Commun (2006) 0.99

Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma. J Oral Pathol Med (2010) 0.98

Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. Biochem J (2007) 0.98

Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration. Mol Biol Cell (2009) 0.97

Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration. Int J Cancer (2002) 0.95

Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines. Prostate (2003) 0.93

Hic-5 promotes endothelial cell migration to lysophosphatidic acid. Am J Physiol Heart Circ Physiol (2007) 0.93

Characterization of a novel focal adhesion kinase inhibitor in human platelets. Biochem Biophys Res Commun (2009) 0.91

Hic-5 interacts with GIT1 with a different binding mode from paxillin. J Biochem (2002) 0.89

Phosphorylation of p125FAK and paxillin focal adhesion proteins in src-transformed cells with different metastatic capacity. FEBS Lett (1999) 0.89

Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase. Biochemistry (2007) 0.88

A visual-quantitative analysis of fibroblastic stromagenesis in breast cancer progression. J Mammary Gland Biol Neoplasia (2004) 0.88

Expression of AR associated protein 55 (ARA55) and androgen receptor in prostate cancer. Prostate (2003) 0.86

Tyrosine-phosphorylated Hic-5 inhibits epidermal growth factor-induced lamellipodia formation. Exp Cell Res (2005) 0.86

Focal adhesion plaque associated cytoskeletons are involved in the invasion and metastasis of human colorectal carcinoma. Cancer Invest (2010) 0.84

Hic-5, an adaptor-like nuclear receptor coactivator. Nucl Recept Signal (2006) 0.81

In vitro and in vivo evidence of pathogenic roles of Hic-5/ARA55 in keloids through Smad pathway and profibrotic transcription. J Dermatol Sci (2010) 0.79

[Expression of HIC-5/ARA55 in colonrectal cancer and its mechanisms of action]. Beijing Da Xue Xue Bao (2006) 0.79

Articles by these authors

FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31

Paxillin: adapting to change. Physiol Rev (2004) 4.48

Paxillin comes of age. J Cell Sci (2008) 3.57

The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol (2002) 2.73

Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol (2004) 1.83

RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. Mol Cell Biol (2003) 1.75

Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell (2002) 1.72

Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell (2005) 1.69

Tension development during contractile stimulation of smooth muscle requires recruitment of paxillin and vinculin to the membrane. Am J Physiol Cell Physiol (2003) 1.56

Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization. J Biol Chem (2001) 1.45

Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition. J Cell Biol (2012) 1.45

Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. J Cell Sci (2008) 1.34

Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta. J Cell Sci (2005) 1.31

FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. J Cell Sci (2009) 1.29

Hic-5 contributes to epithelial-mesenchymal transformation through a RhoA/ROCK-dependent pathway. J Cell Physiol (2007) 1.22

The paxillin LD motifs. FEBS Lett (2002) 1.17

Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts. Mol Biol Cell (2003) 1.16

Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop. J Invest Dermatol (2008) 1.16

Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension development. J Physiol (2003) 1.15

The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner. J Biol Chem (2004) 1.08

EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118. J Biol Chem (2004) 1.08

Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing. Mol Biol Cell (2003) 1.05

Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. J Cell Sci (2005) 1.05

A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. J Biol Chem (2002) 1.03

CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motility. Curr Biol (2006) 1.03

Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol (2008) 1.01

Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. PLoS One (2012) 1.00

LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration. FASEB J (2012) 1.00

Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. J Biol Chem (2005) 0.98

Diverse roles for the paxillin family of proteins in cancer. Genes Cancer (2012) 0.98

Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility. Int J Biochem Cell Biol (2002) 0.97

Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration. Mol Biol Cell (2009) 0.97

Phosphorylation of actopaxin regulates cell spreading and migration. J Cell Biol (2004) 0.97

TGF-beta1 slows the growth of pathogenic myofibroblasts through a mechanism requiring the focal adhesion protein, Hic-5. J Invest Dermatol (2007) 0.93

Ca2+-dependent localization of integrin-linked kinase to cell junctions in differentiating keratinocytes. J Biol Chem (2003) 0.89

Tyrosine-phosphorylated Hic-5 inhibits epidermal growth factor-induced lamellipodia formation. Exp Cell Res (2005) 0.86

Actopaxin is phosphorylated during mitosis and is a substrate for cyclin B1/cdc2 kinase. Biochem J (2002) 0.84

Emerging role of paxillin-PKL in regulation of cell adhesion, polarity and migration. Cell Adh Migr (2010) 0.83

LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One (2013) 0.83

Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion. J Biol Chem (2012) 0.80

CdGAP regulates cell migration and adhesion dynamics in two-and three-dimensional matrix environments. Cytoskeleton (Hoboken) (2012) 0.80

Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration. Mol Biol Cell (2013) 0.78

The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development. Dev Biol (2010) 0.78

Integrin-linked kinase: a possible role in scar contracture. Ann Plast Surg (2004) 0.77

Epidermal growth factor stimulates serine/threonine phosphorylation of the focal adhesion protein paxillin in a MEK-dependent manner in normal rat kidney cells. J Cell Physiol (2002) 0.76

Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradation. PLoS One (2012) 0.76