Published in Nat Cell Biol on January 20, 2008
The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol (2010) 6.91
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol (2009) 4.04
Cell motility through plasma membrane blebbing. J Cell Biol (2008) 3.29
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol (2009) 3.09
Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev (2008) 2.95
The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis (2008) 2.82
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken) (2010) 2.59
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol (2010) 2.58
Applications for ROCK kinase inhibition. Curr Opin Cell Biol (2008) 2.28
Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes Dev (2012) 2.22
Directed cell invasion and migration during metastasis. Curr Opin Cell Biol (2011) 2.12
RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol (2012) 1.69
Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy. EMBO Rep (2012) 1.66
At the leading edge of three-dimensional cell migration. J Cell Sci (2013) 1.66
ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells. Circ Res (2009) 1.61
Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation. J Cell Biol (2011) 1.56
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells. Cell Mol Life Sci (2009) 1.52
MicroRNA-200 family members differentially regulate morphological plasticity and mode of melanoma cell invasion. PLoS One (2010) 1.50
Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions. Small GTPases (2014) 1.38
An improved chamber for direct visualisation of chemotaxis. PLoS One (2010) 1.26
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil. J Cardiovasc Pharmacol (2013) 1.24
Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts. Breast Cancer Res (2010) 1.22
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. Cancer Res (2009) 1.21
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. Nat Cell Biol (2011) 1.17
A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion. J Biol Chem (2009) 1.13
Induction of entosis by epithelial cadherin expression. Cell Res (2014) 1.13
Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Nat Commun (2014) 1.08
FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration. Mol Biol Cell (2012) 1.08
Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun (2013) 1.08
A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion. Br J Cancer (2009) 1.05
Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor. J Biol Chem (2010) 1.03
Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. Endocrinology (2012) 1.03
Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells. PLoS One (2010) 1.01
Regulation of ROCK activity in cancer. J Histochem Cytochem (2012) 1.01
DIAPH3 governs the cellular transition to the amoeboid tumour phenotype. EMBO Mol Med (2012) 1.01
Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal (2008) 0.99
Secretion of microvesicular miRNAs in cellular and organismal aging. Exp Gerontol (2012) 0.98
Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells. J Immunol (2010) 0.98
3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer. Cancer Manag Res (2013) 0.96
3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner. Neoplasia (2012) 0.96
Rho GTPases in collective cell migration. Small GTPases (2014) 0.96
Pigment epithelium-derived factor blocks tumor extravasation by suppressing amoeboid morphology and mesenchymal proteolysis. Neoplasia (2011) 0.95
A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC. J Biol Chem (2010) 0.94
A novel regulatory mechanism links PLCγ1 to PDK1. J Cell Sci (2012) 0.91
Rho-kinase in development and heart failure: insights from genetic models. Pediatr Cardiol (2011) 0.91
Nanog and Oct4 overexpression increases motility and transmigration of melanoma cells. J Cancer Res Clin Oncol (2012) 0.91
Rnd3 regulates lung cancer cell proliferation through notch signaling. PLoS One (2014) 0.90
Rho/ROCK signaling in motility and metastasis of gastric cancer. World J Gastroenterol (2014) 0.90
ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression. Curr Mol Med (2013) 0.89
Modulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxia. PLoS One (2013) 0.88
The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts. Haematologica (2013) 0.88
The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain. PLoS One (2010) 0.87
Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion. Mol Biol Cell (2015) 0.87
Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells. Oncotarget (2015) 0.86
ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain. J Biol Chem (2011) 0.84
Differentially expressed genes in giant cell tumor of bone. Virchows Arch (2011) 0.84
ROCK1 and LIMK2 interact in spread but not blebbing cancer cells. PLoS One (2008) 0.83
Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces. Clin Exp Metastasis (2015) 0.83
Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility. J Biol Chem (2012) 0.83
The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression. J Biol Chem (2013) 0.83
Trading in your spindles for blebs: the amoeboid tumor cell phenotype in prostate cancer. Asian J Androl (2014) 0.83
Matrix-bound PAI-1 supports cell blebbing via RhoA/ROCK1 signaling. PLoS One (2012) 0.83
The 16p13.3 (PDPK1) Genomic Gain in Prostate Cancer: A Potential Role in Disease Progression. Transl Oncol (2012) 0.82
Phosphoinositide 3-kinase p85beta regulates invadopodium formation. Biol Open (2014) 0.82
Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer. World J Biol Chem (2010) 0.81
The GTPase-deficient Rnd proteins are stabilized by their effectors. J Biol Chem (2012) 0.81
EGF-like factors induce expansion of the cumulus cell-oocyte complexes by activating calpain-mediated cell movement. Endocrinology (2012) 0.80
RhoA regulates peroxisome association to microtubules and the actin cytoskeleton. PLoS One (2010) 0.79
PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction. J Cell Biol (2014) 0.78
RhoE is required for contact inhibition and negatively regulates tumor initiation and progression. Oncotarget (2015) 0.78
Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin. Nat Commun (2017) 0.78
Regulation of ROCKII membrane localization through its C-terminus. Exp Cell Res (2011) 0.77
The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. Elife (2016) 0.77
Ras and Rho GTPases on the move: The RasGRF connection. Bioarchitecture (2011) 0.77
The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease. Front Pharmacol (2015) 0.77
Pathophysiological Functions of Rnd3/RhoE. Compr Physiol (2015) 0.77
Microtubule-Mediated Inositol Lipid Signaling Plays Critical Roles in Regulation of Blebbing. PLoS One (2015) 0.76
A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion. Sci Rep (2016) 0.76
Rnd3 as a Novel Target to Ameliorate Microvascular Leakage. J Am Heart Assoc (2016) 0.76
Novel Insights into the Roles of Rho Kinase in Cancer. Arch Immunol Ther Exp (Warsz) (2016) 0.76
Modes of invasion during tumour dissemination. Mol Oncol (2016) 0.76
Rho, ROCK and actomyosin contractility in metastasis as drug targets. F1000Res (2016) 0.75
PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness. BMC Cancer (2015) 0.75
Short-form Ron is a novel determinant of ovarian cancer initiation and progression. Genes Cancer (2016) 0.75
Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2. Biomaterials (2016) 0.75
Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination. Cancers (Basel) (2017) 0.75
MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma. Mol Med Rep (2016) 0.75
RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6. Dev Cell (2017) 0.75
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol (2007) 7.20
Rac activation and inactivation control plasticity of tumor cell movement. Cell (2008) 6.01
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol (2009) 4.39
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res (2005) 4.33
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res (2004) 4.04
Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell (2011) 4.02
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell (2007) 3.89
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol (2006) 3.55
ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. Cancer Cell (2003) 3.28
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol (2009) 3.09
Classifying collective cancer cell invasion. Nat Cell Biol (2012) 2.83
The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis (2008) 2.82
ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma. Cancer Cell (2011) 2.77
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell (2008) 2.65
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol (2010) 2.58
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat Cell Biol (2013) 2.58
Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis. Cancer Res (2006) 2.17
Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends Cell Biol (2005) 2.04
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res (2013) 1.92
Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes. J Pathol (2013) 1.86
Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions. Nat Cell Biol (2013) 1.84
Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Res (2004) 1.81
Deficits in axonal transport precede ALS symptoms in vivo. Proc Natl Acad Sci U S A (2010) 1.66
Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination. Cancer Res (2009) 1.63
New dimensions in cell migration. Nat Rev Mol Cell Biol (2012) 1.46
Cancer dissemination--lessons from leukocytes. Dev Cell (2010) 1.46
Melanoma invasion - current knowledge and future directions. Pigment Cell Res (2007) 1.33
Cell communication networks in cancer invasion. Curr Opin Cell Biol (2011) 1.31
Tumor cell migration in three dimensions. Methods Enzymol (2006) 1.18
Intravital imaging illuminates transforming growth factor beta signaling switches during metastasis. Cancer Res (2010) 1.18
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. Nat Cell Biol (2011) 1.17
In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion. J Cell Sci (2012) 1.05
Imaging tumor cell movement in vivo. Curr Protoc Cell Biol (2007) 1.02
Arkadia regulates tumor metastasis by modulation of the TGF-β pathway. Cancer Res (2013) 0.91
Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. BMC Dev Biol (2009) 0.83
Imaging tumor cell movement in vivo. Curr Protoc Cell Biol (2013) 0.83
Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis (2013) 0.80
Integrin-independent movement of immune cells. F1000 Biol Rep (2009) 0.77
An open data ecosystem for cell migration research. Trends Cell Biol (2014) 0.76
Erik Sahai: getting the whole picture of metastasis. Interview by Sedwick Caitlin. J Cell Biol (2011) 0.75
Chris Marshall (1949-2015)--a personal reflection and tribute. J Cell Sci (2015) 0.75