Published in Toxins (Basel) on August 04, 2015
A Novel Role of Listeria monocytogenes Membrane Vesicles in Inhibition of Autophagy and Cell Death. Front Cell Infect Microbiol (2017) 0.75
Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway. Sci Rep (2016) 0.75
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
TOR signaling in growth and metabolism. Cell (2006) 35.29
mTOR signaling in growth control and disease. Cell (2012) 29.21
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Autophagy regulates lipid metabolism. Nature (2009) 13.33
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
Autophagy and the integrated stress response. Mol Cell (2010) 11.21
Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature (2007) 7.21
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature (2009) 6.74
Escape of intracellular Shigella from autophagy. Science (2004) 6.64
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet (2002) 6.56
An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science (2010) 6.47
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem (2007) 6.28
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem (1997) 6.09
Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol (2007) 5.78
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A (2001) 5.59
Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell (2005) 5.57
Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J Biol Chem (2006) 5.50
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science (2011) 5.46
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med (2009) 5.43
Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol (2005) 5.30
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol (2005) 5.21
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol (2009) 5.06
Statins as a newly recognized type of immunomodulator. Nat Med (2000) 5.00
Bacterial invasion: the paradigms of enteroinvasive pathogens. Science (2004) 4.95
A receptor for the selective uptake and degradation of proteins by lysosomes. Science (1996) 4.89
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov (2008) 4.76
Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol (2012) 4.72
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell (2007) 4.48
The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity (2008) 4.44
Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy (2008) 4.42
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol (2009) 4.31
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol (2008) 4.19
Contribution of individual toxin components to virulence of Bacillus anthracis. Infect Immun (1991) 4.17
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe (2008) 4.16
Autophagy in infection, inflammation and immunity. Nat Rev Immunol (2013) 4.16
Innate and adaptive immunity through autophagy. Immunity (2007) 4.11
The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread. Infect Immun (1995) 4.02
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe (2009) 3.95
Activation of antibacterial autophagy by NADPH oxidases. Proc Natl Acad Sci U S A (2009) 3.87
LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J (2010) 3.68
Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication. Proc Natl Acad Sci U S A (2006) 3.68
Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity (2010) 3.62
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res (2005) 3.54
AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem (2006) 3.53
Microautophagy of cytosolic proteins by late endosomes. Dev Cell (2011) 3.51
p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol Cell (2011) 3.46
Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins. Infect Immun (2005) 3.39
Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37
Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature (2012) 3.33
Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci (2010) 3.32
Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging. Science (2013) 3.27
Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev (2009) 3.20
A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe (2010) 3.18
A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med (2011) 3.17
Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci U S A (2011) 3.11
Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat Cell Biol (2009) 3.05
Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy. Proc Natl Acad Sci U S A (2007) 3.05
The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol (2013) 3.04
The discovery and development of HMG-CoA reductase inhibitors. J Lipid Res (1992) 3.02
Chaperone-mediated autophagy. Autophagy (2007) 3.00
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol (2008) 2.90
Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion. Clin Microbiol Rev (2008) 2.86
A clinical drug library screen identifies astemizole as an antimalarial agent. Nat Chem Biol (2006) 2.72
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe (2012) 2.70
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. J Biol Chem (2008) 2.63
Life on the inside: the intracellular lifestyle of cytosolic bacteria. Nat Rev Microbiol (2009) 2.62
An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (2005) 2.60
Canonical and non-canonical autophagy: variations on a common theme of self-eating? Nat Rev Mol Cell Biol (2011) 2.52
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.45
Statins for the prevention and treatment of infections: a systematic review and meta-analysis. Arch Intern Med (2009) 2.43
Adenosine A2B receptors. Pharmacol Rev (1997) 2.38
Pore-forming protein toxins: from structure to function. Prog Biophys Mol Biol (2005) 2.36
Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36
The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy. Proc Natl Acad Sci U S A (2009) 2.30
Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae. Proc Natl Acad Sci U S A (2007) 2.27
An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation. J Cell Biol (1997) 2.24
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23
Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res (2004) 2.20
Bacterial pore-forming toxins: the (w)hole story? Cell Mol Life Sci (2008) 2.16