Published in Autophagy on May 12, 2008
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
The double-edged sword of autophagy modulation in cancer. Clin Cancer Res (2009) 5.46
Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res (2011) 5.40
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol (2009) 4.95
The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther (2011) 4.39
The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25
The Beclin 1 interactome. Curr Opin Cell Biol (2010) 4.13
The regulation of autophagy - unanswered questions. J Cell Sci (2011) 2.73
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol (2010) 2.33
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem (2008) 2.31
A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ (2010) 2.25
Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J (2009) 2.08
Induction of autophagy is essential for monocyte-macrophage differentiation. Blood (2012) 2.05
ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death. Autophagy (2008) 1.87
Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11. Autophagy (2008) 1.86
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest (2012) 1.85
Autophagy and apoptosis: what is the connection? Trends Cell Biol (2011) 1.81
Functions of autophagy in normal and diseased liver. Autophagy (2013) 1.81
Mammalian macroautophagy at a glance. J Cell Sci (2009) 1.78
Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Exp Gerontol (2009) 1.74
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy. EMBO J (2011) 1.68
Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood (2012) 1.66
Autophagy: for better or for worse. Cell Res (2011) 1.65
Autophagy and disease: always two sides to a problem. J Pathol (2011) 1.64
Mechanisms of cell death in heart disease. Arterioscler Thromb Vasc Biol (2012) 1.63
Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol (2010) 1.53
Disturbed mitochondrial dynamics and neurodegenerative disorders. Nat Rev Neurol (2014) 1.52
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. J Cell Biol (2011) 1.52
Multiple functions of BCL-2 family proteins. Cold Spring Harb Perspect Biol (2013) 1.51
ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem (2008) 1.45
The role of autophagy in tumour development and cancer therapy. Expert Rev Mol Med (2009) 1.43
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies. Nat Rev Cancer (2016) 1.42
Cardiomyocyte death in doxorubicin-induced cardiotoxicity. Arch Immunol Ther Exp (Warsz) (2009) 1.41
Sphingolipids: regulators of crosstalk between apoptosis and autophagy. J Lipid Res (2012) 1.40
Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes. Diabetes (2012) 1.37
Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells. Autophagy (2010) 1.37
Functions of autophagy in hepatic and pancreatic physiology and disease. Gastroenterology (2011) 1.35
Development of autophagy inducers in clinical medicine. J Clin Invest (2015) 1.33
Autophagy and cancer therapy. Cancer Biol Ther (2011) 1.32
Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68. PLoS Pathog (2009) 1.31
Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis (2014) 1.30
Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells. Autophagy (2012) 1.28
Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK. Cell Death Dis (2010) 1.23
Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation. Cell Cycle (2012) 1.23
Autophagy: molecular machinery, regulation, and implications for renal pathophysiology. Am J Physiol Renal Physiol (2009) 1.22
Molecules and their functions in autophagy. Exp Mol Med (2012) 1.21
Unfolded protein response to autophagy as a promising druggable target for anticancer therapy. Ann N Y Acad Sci (2012) 1.21
Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation. J Biol Chem (2011) 1.20
Addition of a histone deacetylase inhibitor redirects tamoxifen-treated breast cancer cells into apoptosis, which is opposed by the induction of autophagy. Breast Cancer Res Treat (2011) 1.18
When apoptosis meets autophagy: deciding cell fate after trauma and sepsis. Trends Mol Med (2009) 1.17
GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy. Cell Death Dis (2010) 1.17
Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy. J Biol Chem (2008) 1.16
Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem (2010) 1.16
Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak. Proc Natl Acad Sci U S A (2014) 1.14
Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation. J Signal Transduct (2011) 1.14
PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast. J Lipids (2011) 1.11
Role of inositol trisphosphate receptors in autophagy in DT40 cells. J Biol Chem (2010) 1.11
Autophagy regulation in cancer development and therapy. Am J Cancer Res (2010) 1.11
Hormesis, cell death and aging. Aging (Albany NY) (2011) 1.11
Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells. Mol Biol Cell (2010) 1.10
Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage. Am J Pathol (2009) 1.10
Ceramide-induced autophagy: to junk or to protect cells? Autophagy (2009) 1.09
MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol (2011) 1.09
Increased expression of the integral membrane protein ErbB2 in Chinese hamster ovary cells expressing the anti-apoptotic gene Bcl-xL. Protein Expr Purif (2009) 1.09
Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology (2013) 1.08
Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death. J Natl Cancer Inst (2011) 1.08
p53 and ARF: unexpected players in autophagy. Trends Cell Biol (2010) 1.08
Negative regulation of autophagy. Cell Death Differ (2010) 1.07
Dasatinib induces autophagic cell death in human ovarian cancer. Cancer (2010) 1.07
Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. PLoS One (2010) 1.06
Atg14: a key player in orchestrating autophagy. Int J Cell Biol (2011) 1.05
miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death. Mol Cancer (2013) 1.04
PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage. Cell Death Differ (2013) 1.04
OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins. Cancer Biol Ther (2010) 1.03
14-3-3Tau regulates Beclin 1 and is required for autophagy. PLoS One (2010) 1.03
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. Cell Death Dis (2013) 1.03
The emerging importance of autophagy in pulmonary diseases. Chest (2012) 1.03
Tumor suppression and promotion by autophagy. Biomed Res Int (2014) 1.02
PKC delta signaling: a dual role in regulating hypoxic stress-induced autophagy and apoptosis. Autophagy (2009) 1.02
Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway. Int J Biol Sci (2012) 1.02
Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase. Cell Death Dis (2013) 1.01
Hepatic response to oxidative injury in long-lived Ames dwarf mice. FASEB J (2010) 1.01
Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol (2015) 1.01
Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation. J Virol (2012) 1.01
The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH. Mol Biol Cell (2011) 1.01
Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology. Trends Cell Biol (2015) 1.00
Death upon a kiss: mitochondrial outer membrane composition and organelle communication govern sensitivity to BAK/BAX-dependent apoptosis. Chem Biol (2013) 1.00
Autophagy inhibition by sustained overproduction of IL6 contributes to arsenic carcinogenesis. Cancer Res (2014) 0.99
Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy. Acta Pharmacol Sin (2011) 0.99
T lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy. FASEB J (2012) 0.99
RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. PLoS One (2011) 0.98
A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis. Blood (2014) 0.97
Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability. Biochem J (2013) 0.97
BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. Autophagy (2015) 0.96
Autophagy is active in normal colon mucosa. Autophagy (2012) 0.96
Frontier of epilepsy research - mTOR signaling pathway. Exp Mol Med (2011) 0.95
Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway. PLoS One (2011) 0.95
The hallmarks of cancer. Cell (2000) 113.05
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Cell death: critical control points. Cell (2004) 22.56
An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature (2005) 22.40
Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59
Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47
Mitochondrial membrane permeabilization in cell death. Physiol Rev (2007) 12.72
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72
Role of autophagy in cancer. Nat Rev Cancer (2007) 10.88
Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol (2007) 10.79
Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell (2006) 10.29
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene (2007) 10.08
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol (2006) 9.17
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol (2007) 8.29
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol (1998) 7.41
Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep (2001) 7.13
Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol (2005) 7.11
Ambra1 regulates autophagy and development of the nervous system. Nature (2007) 6.94
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol (2006) 6.47
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35
Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr (2007) 5.75
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem (2007) 5.21
Cell biology: autophagy and cancer. Nature (2007) 4.40
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ (2006) 4.29
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22
Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ (2007) 4.12
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy (2005) 4.02
Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ (2006) 3.95
Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem (1998) 3.93
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Sci (2005) 3.93
Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO J (1996) 3.68
Cell death modalities: classification and pathophysiological implications. Cell Death Differ (2007) 3.19
BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ (2005) 2.91
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res (2004) 2.78
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J (2004) 2.77
Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy (2006) 2.37
The multidomain proapoptotic molecules Bax and Bak are directly activated by heat. Proc Natl Acad Sci U S A (2005) 2.30
Bcl-2 inhibition of autophagy: a new route to cancer? Cancer Res (2006) 2.11
Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1. J Mol Biol (2007) 2.08
Differential interactions between Beclin 1 and Bcl-2 family members. Autophagy (2007) 2.03
Upgrading the BCL-2 network. Nat Cell Biol (2006) 1.59
Cell cycle-dependent induction of autophagy, mitophagy and reticulophagy. Cell Cycle (2007) 1.46
Why yeast cells can undergo apoptosis: death in times of peace, love, and war. J Cell Biol (2006) 1.38
BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells. Oncogene (2007) 1.22
Redundant cell death mechanisms as relics and backups. Cell Death Differ (2005) 1.12
Downregulation of autophagy by herpesvirus Bcl-2 homologs. Autophagy (2007) 1.12
The inositol trisphosphate receptor in the control of autophagy. Autophagy (2007) 1.02
Mitophagy: the life-or-death dichotomy includes yeast. Autophagy (2007) 0.98
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47
The hallmarks of aging. Cell (2013) 14.29
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90
The pathophysiology of mitochondrial cell death. Science (2004) 13.87
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72
Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73
Immunological aspects of cancer chemotherapy. Nat Rev Immunol (2008) 6.61
Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol (2006) 6.13
Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov (2006) 5.99
Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97
Autophagy and aging. Cell (2011) 5.96
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science (2011) 5.62
Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23
Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00
Cell death by mitotic catastrophe: a molecular definition. Oncogene (2004) 4.75
Cell death by necrosis: towards a molecular definition. Trends Biochem Sci (2006) 4.67
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60
An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35
Immunogenic and tolerogenic cell death. Nat Rev Immunol (2009) 4.34
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med (2005) 4.32
Targeting mitochondria for cancer therapy. Nat Rev Drug Discov (2010) 4.07
The anticancer immune response: indispensable for therapeutic success? J Clin Invest (2008) 4.01
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Sci (2005) 3.93
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82
Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science (2011) 3.74
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity (2013) 3.73
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med (2005) 3.64
The secret ally: immunostimulation by anticancer drugs. Nat Rev Drug Discov (2012) 3.60
Decoding cell death signals in inflammation and immunity. Cell (2010) 3.41
Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat Rev Clin Oncol (2011) 3.41
Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol (2011) 3.40
Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity (2013) 3.26
Does autophagy contribute to cell death? Autophagy (2005) 3.21
A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med (2006) 3.21
Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle (2006) 3.21
AIF deficiency compromises oxidative phosphorylation. EMBO J (2004) 3.19
BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 3.03
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev (2007) 2.96
Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle (2009) 2.72
Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72
Platelet formation is the consequence of caspase activation within megakaryocytes. Blood (2002) 2.62
Necroptosis: a specialized pathway of programmed necrosis. Cell (2008) 2.61
Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med (2003) 2.56
Autophagy regulation by p53. Curr Opin Cell Biol (2010) 2.56
Can autophagy promote longevity? Nat Cell Biol (2010) 2.55
Cell death assays for drug discovery. Nat Rev Drug Discov (2011) 2.51
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol (2002) 2.47
The IKK complex contributes to the induction of autophagy. EMBO J (2009) 2.41
Fatty acids trigger mitochondrion-dependent necrosis. Cell Cycle (2010) 2.37
Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36
An AIF orthologue regulates apoptosis in yeast. J Cell Biol (2004) 2.33
Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32
Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32
Immunogenic tumor cell death for optimal anticancer therapy: the calreticulin exposure pathway. Clin Cancer Res (2010) 2.29
Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol (2012) 2.28
miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Res (2010) 2.24
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23
Viral control of mitochondrial apoptosis. PLoS Pathog (2008) 2.21
Nonapoptotic role for Apaf-1 in the DNA damage checkpoint. Mol Cell (2007) 2.20
Prognostic and predictive impact of intra- and peritumoral immune infiltrates. Cancer Res (2011) 2.16
Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell (2012) 2.14
Alternative cell death mechanisms in development and beyond. Genes Dev (2010) 2.14
Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. Oncogene (2003) 2.09
Involvement of p38alpha in the mitotic progression of p53(-/-) tetraploid cells. Cell Cycle (2010) 2.08
Decoding cell death signals in liver inflammation. J Hepatol (2013) 2.05
To die or not to die: that is the autophagic question. Curr Mol Med (2008) 2.05
Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med (2011) 2.04
Methods for the assessment of mitochondrial membrane permeabilization in apoptosis. Apoptosis (2007) 2.04
Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle (2008) 2.03
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
Methods for assessing autophagy and autophagic cell death. Methods Mol Biol (2008) 1.96
Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy (2008) 1.95
Chemotherapy and radiotherapy: cryptic anticancer vaccines. Semin Immunol (2010) 1.94
Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Cell Cycle (2013) 1.94
Apoptosis and genomic instability. Nat Rev Mol Cell Biol (2004) 1.92
Anti- and pro-tumor functions of autophagy. Biochim Biophys Acta (2009) 1.92
Mitochondria, the killer organelles and their weapons. J Cell Physiol (2002) 1.92
Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest (2005) 1.91
Autophagy is required for the activation of NFκB. Cell Cycle (2012) 1.89
Apoptosis regulation in tetraploid cancer cells. EMBO J (2006) 1.89
High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab (2011) 1.89
Immunogenic cancer cell death: a key-lock paradigm. Curr Opin Immunol (2008) 1.89
Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology (2012) 1.88
A dual role of p53 in the control of autophagy. Autophagy (2008) 1.88
Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci (2002) 1.88
Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease. J Clin Invest (2011) 1.86
Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci (2009) 1.85
Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol (2012) 1.85
Autophagic removal of micronuclei. Cell Cycle (2012) 1.85
Chemotherapy induces ATP release from tumor cells. Cell Cycle (2009) 1.83
Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity. Cancer Res (2010) 1.82