Published in Development on August 07, 2015
Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol (2016) 0.95
NRP1 function and targeting in neurovascular development and eye disease. Prog Retin Eye Res (2016) 0.82
Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II. Circ Res (2016) 0.80
Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth. Angiogenesis (2016) 0.77
Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability. Circ Res (2017) 0.76
Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development. Sci Rep (2017) 0.75
Small Rho GTPase-mediated actin dynamics at endothelial adherens junctions. Small GTPases (2016) 0.75
Src- and Fyn-dependent apical membrane trafficking events control endothelial lumen formation during vascular tube morphogenesis. PLoS One (2017) 0.75
Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis. BMC Med Genomics (2017) 0.75
Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis. Nat Commun (2017) 0.75
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol (2003) 12.96
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell (1999) 8.07
CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J Cell Biol (1990) 7.29
Filopodia: molecular architecture and cellular functions. Nat Rev Mol Cell Biol (2008) 6.40
Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J Cell Biol (1990) 6.29
Vasculogenesis. Annu Rev Cell Dev Biol (1995) 5.41
Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Cell (2005) 4.86
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature (2010) 4.85
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell (2002) 4.68
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest (2002) 3.70
A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol (2010) 3.70
Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc Natl Acad Sci U S A (1993) 3.37
The molecular basis of vascular lumen formation in the developing mouse aorta. Dev Cell (2009) 3.08
Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat Cell Biol (2005) 3.02
Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. J Cell Sci (1997) 2.79
Cytochalasin D inhibits actin polymerization and induces depolymerization of actin filaments formed during platelet shape change. Nature (1981) 2.63
Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling. J Cell Sci (2008) 2.43
Cdc42-mediated tubulogenesis controls cell specification. Cell (2009) 2.35
The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat Cell Biol (2014) 2.21
Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol (2000) 2.19
Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science (2011) 2.12
Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42. Curr Biol (2003) 2.11
The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices. J Cell Sci (2002) 2.05
Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts. Mol Biol Cell (2006) 1.96
Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. J Cell Biol (1999) 1.96
VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly. Blood (2004) 1.81
Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc Natl Acad Sci U S A (2007) 1.74
Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci (2007) 1.73
Generation of branched actin networks: assembly and regulation of the N-WASP and WAVE molecular machines. Bioessays (2010) 1.53
Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II. J Cell Sci (2000) 1.48
Biphasic Ngn3 expression in the developing pancreas. Dev Dyn (2008) 1.47
VEGF and FGF prime vascular tube morphogenesis and sprouting directed by hematopoietic stem cell cytokines. Blood (2011) 1.46
Blood island formation: longstanding observations and modern interpretations. Exp Hematol (2005) 1.44
Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet (2013) 1.39
Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting. Int Rev Cell Mol Biol (2011) 1.36
Cdc42 regulates the restoration of endothelial barrier function. Circ Res (2003) 1.31
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood (2007) 1.28
Endothelial cell-pericyte interactions stimulate basement membrane matrix assembly: influence on vascular tube remodeling, maturation, and stabilization. Microsc Microanal (2011) 1.20
Molecular mechanisms controlling vascular lumen formation in three-dimensional extracellular matrices. Cells Tissues Organs (2011) 1.19
Signaling role of Cdc42 in regulating mammalian physiology. J Biol Chem (2010) 1.18
Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development (2009) 1.14
The cytoskeletal mechanisms of cell-cell junction formation in endothelial cells. Mol Biol Cell (2011) 1.11
Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation. Dev Biol (2009) 1.10
Phosphoinositides control epithelial development. Cell Cycle (2007) 1.05
Study of the murine allantois by allantoic explants. Dev Biol (2001) 1.05
Involvement of nectin-activated Cdc42 small G protein in organization of adherens and tight junctions in Madin-Darby canine kidney cells. J Biol Chem (2003) 1.04
Identification of a heritable model of testicular germ cell tumor in the zebrafish. Zebrafish (2009) 1.02
Stepwise arteriovenous fate acquisition during mammalian vasculogenesis. Dev Dyn (2011) 1.01
Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res (2011) 1.01
Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion. BMC Cancer (2009) 0.99
Cdc42 regulates the restoration of endothelial adherens junctions and permeability. Trends Cardiovasc Med (2007) 0.90
Ancestral vascular lumen formation via basal cell surfaces. PLoS One (2009) 0.90
The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro. Small GTPases (2011) 0.88
Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Mol Cell Biol (2013) 0.87
The initiation of blood flow and flow induced events in early vascular development. Semin Cell Dev Biol (2011) 0.86
Protein filaments: Bundles from boundaries. Nat Mater (2010) 0.83
The generation of the endothelial specific cdc42-deficient mice and the effect of cdc42 deletion on the angiogenesis and embryonic development. Chin Med J (Engl) (2011) 0.81
RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration. Development (2013) 0.80
Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis. Arterioscler Thromb Vasc Biol (2011) 0.79
The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor in cancer cells. Int J Oncol (2014) 0.78