The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis.

PubWeight™: 0.84‹?›

🔗 View Article (PMC 4516870)

Published in Front Physiol on July 28, 2015

Authors

Joeri Lambrecht1, Inge Mannaerts1, Leo A van Grunsven1

Author Affiliations

1: Liver Cell Biology Lab, Department of Biomedical Sciences, Vrije Universiteit Brussel Brussels, Belgium.

Articles cited by this

(truncated to the top 100)

Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75

The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49

Identification of tissue-specific microRNAs from mouse. Curr Biol (2002) 34.55

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell (1993) 33.79

The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70

Nuclear export of microRNA precursors. Science (2003) 16.59

Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell (2005) 15.26

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol (1996) 15.20

Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science (2005) 13.84

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet (2004) 12.97

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell (2005) 9.27

Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest (2005) 8.45

A microRNA signature of hypoxia. Mol Cell Biol (2006) 7.24

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev (2001) 6.35

Characterization of extracellular circulating microRNA. Nucleic Acids Res (2011) 6.24

Complications following percutaneous liver biopsy. A multicentre retrospective study on 68,276 biopsies. J Hepatol (1986) 6.20

Liver cirrhosis. Lancet (2008) 6.11

Liver fibrosis -- from bench to bedside. J Hepatol (2003) 5.80

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol (1996) 5.52

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol (2009) 5.05

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology (2010) 4.72

MicroRNA functions in stress responses. Mol Cell (2010) 4.46

Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE (2007) 4.46

MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One (2006) 4.29

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun (2013) 4.22

Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology (2007) 4.06

miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biol Ther (2007) 3.93

Endoplasmic reticulum stress in liver disease. J Hepatol (2010) 3.90

NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest (2003) 3.69

Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell (2009) 3.68

Mitochondria--a nexus for aging, calorie restriction, and sirtuins? Cell (2008) 3.38

High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma. Mol Cancer (2007) 3.24

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome. RNA (2005) 3.11

MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT. Cell Cycle (2009) 3.07

Oxidative stress: from basic research to clinical application. Am J Med (1991) 2.82

Oxidative stress-related molecules and liver fibrosis. J Hepatol (2001) 2.75

Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J Biol Chem (2009) 2.66

Cross talk between mitochondria and NADPH oxidases. Free Radic Biol Med (2011) 2.63

Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis. Hepatology (2012) 2.61

Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett (2009) 2.40

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science (2012) 2.25

The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature. Circ Res (2010) 2.19

miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma. Cancer Res (2010) 2.18

Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med (2000) 2.13

miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis. J Hepatol (2009) 2.03

Liver fibrosis. Biochem J (2008) 1.97

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med (2011) 1.94

An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem (2009) 1.90

Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells. J Hepatol (2009) 1.89

Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol (2007) 1.88

Elevated levels of serum advanced glycation end products in patients with non-alcoholic steatohepatitis. J Gastroenterol Hepatol (2007) 1.85

The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One (2011) 1.81

Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis. Liver Int (2010) 1.79

miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition. Cell Death Differ (2011) 1.77

MicroRNAs in liver disease. Gastroenterology (2012) 1.76

miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1. Mol Cell (2010) 1.76

Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis - amelioration by liver transplantation. J Hepatol (2002) 1.76

Expression of platelet-derived growth factor-C and insulin-like growth factor I in hepatic stellate cells is inhibited by miR-29. Lab Invest (2012) 1.75

Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Res (2011) 1.74

Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. Hepatology (2006) 1.71

Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol (2006) 1.61

Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. J Gastroenterol Hepatol (2008) 1.59

ER stress: can the liver cope? J Hepatol (2006) 1.58

Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis. Am J Pathol (1999) 1.58

Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice. Am J Physiol Gastrointest Liver Physiol (2009) 1.52

Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism. Hepatology (2005) 1.42

Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction. PLoS One (2011) 1.42

In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C. J Pathol (2010) 1.41

Primary biliary cirrhosis is associated with altered hepatic microRNA expression. J Autoimmun (2009) 1.41

Suppression of hepatic stellate cell activation by microRNA-29b. Biochem Biophys Res Commun (2011) 1.39

MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4. Cell Signal (2012) 1.37

miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. Oncogene (2012) 1.34

Hypoxia and hypoxia inducible factors: diverse roles in liver diseases. Hepatology (2012) 1.32

NOX in liver fibrosis. Arch Biochem Biophys (2007) 1.29

Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Hepatology (1994) 1.26

miRNA modulation of the cellular stress response. Future Oncol (2008) 1.25

Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role. Clin Res Hepatol Gastroenterol (2011) 1.25

Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress. J Biol Chem (2000) 1.24

Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways. FEBS J (2009) 1.23

The potential of microRNAs in liver fibrosis. Cell Signal (2012) 1.22

miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression. J Hepatol (2012) 1.19

Redox regulation of lung inflammation: role of NADPH oxidase and NF-kappaB signalling. Biochem Soc Trans (2007) 1.18

Modulation of the unfolded protein response is the core of microRNA-122-involved sensitivity to chemotherapy in hepatocellular carcinoma. Neoplasia (2011) 1.16

Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells. Apoptosis (2009) 1.13

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. J Hepatol (2013) 1.12

CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. Hepatology (1999) 1.09

Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation. Exp Cell Res (2011) 1.09

MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway. J Pathol (2014) 1.08

Interspecies regulation of microRNAs and their targets. Biochim Biophys Acta (2008) 1.08

Protective role of estrogen-induced miRNA-29 expression in carbon tetrachloride-induced mouse liver injury. J Biol Chem (2012) 1.07

Hypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-beta signaling pathway. FEBS Lett (2006) 1.06

MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response. J Cell Biol (2012) 1.05

Inactivation of myofibroblasts during regression of liver fibrosis. Cell Cycle (2013) 1.04

Induction of microRNA-214-5p in human and rodent liver fibrosis. Fibrogenesis Tissue Repair (2012) 1.02

Identification of radiation-induced microRNA transcriptome by next-generation massively parallel sequencing. J Radiat Res (2013) 1.02

Circulating microRNAs as markers of liver inflammation, fibrosis and cancer. J Hepatol (2014) 0.98

microRNA-199a-5p protects hepatocytes from bile acid-induced sustained endoplasmic reticulum stress. Cell Death Dis (2013) 0.97

Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation. Mol Cell Biochem (2013) 0.97

Hypoxia, angiogenesis and liver fibrogenesis in the progression of chronic liver diseases. World J Gastroenterol (2010) 0.96

miRNA studies in in vitro and in vivo activated hepatic stellate cells. World J Gastroenterol (2011) 0.94