Published in Elife on August 18, 2015
Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104. J Mol Biol (2015) 0.85
Amyloid formation: functional friend or fearful foe? J Intern Med (2016) 0.78
Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils. Biol Open (2015) 0.78
Semen amyloids participate in spermatozoa selection and clearance. Elife (2017) 0.76
Designer protein disaggregases to counter neurodegenerative disease. Curr Opin Genet Dev (2017) 0.76
Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors. Elife (2016) 0.76
A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy. Beilstein J Org Chem (2016) 0.75
The KT Jeang Retrovirology prize 2016: Frank Kirchhoff. Retrovirology (2016) 0.75
Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation. Chem Commun (Camb) (2016) 0.75
GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. J Chem Theory Comput (2008) 34.90
Complete replication of hepatitis C virus in cell culture. Science (2005) 18.59
Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations. J Comput Chem (2004) 17.97
Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet (2001) 13.32
Structure of the cross-beta spine of amyloid-like fibrils. Nature (2005) 11.56
A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc Natl Acad Sci U S A (2002) 9.55
Tenofovir-based preexposure prophylaxis for HIV infection among African women. N Engl J Med (2015) 9.20
Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission. N Engl J Med (2008) 6.00
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J Med Chem (2002) 5.67
Inhibiting sexual transmission of HIV-1 infection. Nat Rev Microbiol (2003) 5.29
Semen-derived amyloid fibrils drastically enhance HIV infection. Cell (2007) 5.23
The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci U S A (2006) 4.15
A specific mechanism of nonspecific inhibition. J Med Chem (2003) 3.93
Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J Virol (2006) 3.75
Identifying the amylome, proteins capable of forming amyloid-like fibrils. Proc Natl Acad Sci U S A (2010) 3.50
Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia. J Virol (1994) 3.05
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe (2011) 3.05
Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol (2008) 2.98
SwissParam: a fast force field generation tool for small organic molecules. J Comput Chem (2011) 2.74
Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages. J Virol (2011) 2.55
Hepatitis C virus: evidence for sexual transmission. BMJ (1991) 2.50
On the nucleation of amyloid beta-protein monomer folding. Protein Sci (2005) 2.47
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature (2011) 2.46
Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides. J Virol (2008) 2.43
A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A (2010) 2.41
The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J Virol (2008) 2.38
Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E. J Gen Virol (2008) 2.35
A review of the physical and chemical properties of human semen and the formulation of a semen simulant. J Androl (2005) 2.07
Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. J Biol Chem (2010) 2.05
Interpreting steep dose-response curves in early inhibitor discovery. J Med Chem (2006) 2.00
Implementation of the CHARMM Force Field in GROMACS: Analysis of Protein Stability Effects from Correction Maps, Virtual Interaction Sites, and Water Models. J Chem Theory Comput (2010) 2.00
The phospholipid composition of extracellular herpes simplex virions differs from that of host cell nuclei. Virology (1994) 1.86
Lipid composition and fluidity of the human immunodeficiency virus. Proc Natl Acad Sci U S A (1988) 1.79
The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection. Proc Natl Acad Sci U S A (2009) 1.77
Anti-HIV-1 activity of anionic polymers: a comparative study of candidate microbicides. BMC Infect Dis (2002) 1.75
Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection. Cell Host Microbe (2011) 1.72
Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI. Retrovirology (2010) 1.70
A temperature predictor for parallel tempering simulations. Phys Chem Chem Phys (2008) 1.63
Vaginal microbicides: moving ahead after an unexpected setback. AIDS (2007) 1.56
Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils. J Biol Chem (2004) 1.55
The development of vaginal microbicides for the prevention of HIV transmission. PLoS Med (2005) 1.54
Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism. J Virol (2002) 1.53
Efficient transformation of primary human amniocytes by E1 functions of Ad5: generation of new cell lines for adenoviral vector production. Hum Gene Ther (2000) 1.47
Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane. J Cell Biol (2012) 1.44
Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides. BMC Infect Dis (2006) 1.42
Cytomegalovirus infection in sex partners: evidence for sexual transmission. J Infect Dis (1985) 1.42
Aβ(1-42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease. Nat Struct Mol Biol (2015) 1.42
Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection. J Virol (2011) 1.42
Stability and equilibria of promiscuous aggregates in high protein milieus. Mol Biosyst (2007) 1.38
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. J Am Chem Soc (2011) 1.25
Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004). AIDS (2011) 1.22
Aromatic interactions by molecular tweezers and clips in chemical and biological systems. Acc Chem Res (2012) 1.17
Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses. Nat Nanotechnol (2013) 1.12
Comparative lipidomics analysis of HIV-1 particles and their producer cell membrane in different cell lines. Cell Microbiol (2013) 1.11
A DNA-based method to assay total and infectious particle contents and helper virus contamination in high-capacity adenoviral vector preparations. Hum Gene Ther (2002) 1.10
Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains. J Am Chem Soc (2009) 1.09
Mechanism of fibril formation by a 39-residue peptide (PAPf39) from human prostatic acidic phosphatase. Biochemistry (2009) 1.09
Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms. J Am Chem Soc (2010) 1.08
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun (2014) 1.08
Probing HIV-1 membrane liquid order by Laurdan staining reveals producer cell-dependent differences. J Biol Chem (2009) 1.07
A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology (2012) 1.06
NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286). J Am Chem Soc (2009) 1.06
Polyanions--a lost chance in the fight against HIV and other virus diseases? Antivir Chem Chemother (2000) 1.06
A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion. PLoS Pathog (2013) 1.05
Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry. Nat Chem (2014) 1.05
Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem Neurosci (2012) 1.04
Variation in virological parameters and antibody responses in macaques after atraumatic vaginal exposure to a pathogenic primary isolate of SIVmac251. Res Virol (1998) 1.02
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo. Neurotherapeutics (2012) 1.01
Molecular tweezers modulate 14-3-3 protein-protein interactions. Nat Chem (2013) 1.01
Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide. J Biol Chem (2012) 0.98
Effect of semen and seminal amyloid on vaginal transmission of simian immunodeficiency virus. Retrovirology (2013) 0.97
Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides. Sci Transl Med (2014) 0.97
A molecular tweezer for lysine and arginine. J Am Chem Soc (2005) 0.96
Core sequence of PAPf39 amyloid fibrils and mechanism of pH-dependent fibril formation: the role of monomer conformation. Biochemistry (2012) 0.92
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain (2012) 0.91
The Surprising Role of Amyloid Fibrils in HIV Infection. Biology (Basel) (2012) 0.91
Molecular clip and tweezer introduce new mechanisms of enzyme inhibition. J Am Chem Soc (2008) 0.87
Discovery of modulators of HIV-1 infection from the human peptidome. Nat Rev Microbiol (2014) 0.85
Molecular tweezers with varying anions: a comparative study. J Org Chem (2013) 0.85
Molecular basis for preventing α-synuclein aggregation by a molecular tweezer. J Biol Chem (2014) 0.85
Molecular tweezer and clip in aqueous solution: unexpected self-assembly, powerful host-guest complex formation, quantum chemical 1H NMR shift calculation. J Am Chem Soc (2006) 0.85
Amyloid β-protein assembly: The effect of molecular tweezers CLR01 and CLR03. J Phys Chem B (2015) 0.84
Molecular tweezers targeting transthyretin amyloidosis. Neurotherapeutics (2014) 0.82
Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism. ACS Chem Biol (2015) 0.79
A Potent, Broad-Spectrum Antiviral Agent that Targets Viral Membranes. Viruses (2010) 0.79
Improving preclinical models of HIV microbicide efficacy. Trends Microbiol (2015) 0.78
The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. Biochemistry (2015) 0.77
Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity. BMC Pharmacol Toxicol (2014) 0.77
A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel. Soft Matter (2015) 0.76
Sexually transmitted viruses. Yale J Biol Med (1989) 0.75
Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. J Virol (2014) 0.89
Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance. MBio (2016) 0.80
Cathepsin G-mediated proteolytic degradation of MHC class I molecules to facilitate immune detection of human glioblastoma cells. Cancer Immunol Immunother (2016) 0.76
Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog (2017) 0.75
Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells. Oncotarget (2016) 0.75
Efficient Vpu-mediated tetherin antagonism by an HIV-1 group O strain. J Virol (2017) 0.75
A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein. Neurotherapeutics (2017) 0.75
Primary HIV-1 Strains Use Nef To Downmodulate HLA-E Surface Expression. J Virol (2019) 0.75