Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 26304120)

Published in J Biol Chem on August 24, 2015

Authors

Leighanne A Brammer Basta1, Anita Ghosh2, Ying Pan2, Jean Jakoncic3, Evan P Lloyd4, Craig A Townsend4, Gyanu Lamichhane5, Mario A Bianchet6

Author Affiliations

1: From the Taskforce to study Resistance Emergence and Antimicrobial development Technology (TREAT) and Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231.
2: Structural Enzymology and Thermodynamics Group, Department of Biophysics and Biophysical Chemistry and.
3: National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, New York 11973, and.
4: Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218.
5: From the Taskforce to study Resistance Emergence and Antimicrobial development Technology (TREAT) and Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, lamichhane@jhu.edu.
6: Structural Enzymology and Thermodynamics Group, Department of Biophysics and Biophysical Chemistry and Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, bianchet@jhmi.edu.

Articles cited by this

UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47

PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52

Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46

Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr (2011) 67.55

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62

Inference of macromolecular assemblies from crystalline state. J Mol Biol (2007) 44.95

ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics (1999) 21.85

Serine beta-lactamases and penicillin-binding proteins. Annu Rev Microbiol (1991) 6.63

An outbreak involving extensive transmission of a virulent strain of Mycobacterium tuberculosis. N Engl J Med (1998) 6.60

Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science (2009) 3.73

A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2003) 3.70

Structural modifications in the peptidoglycan of Escherichia coli associated with changes in the state of growth of the culture. J Bacteriol (1985) 2.96

Three-dimensional structure of the bacterial cell wall peptidoglycan. Proc Natl Acad Sci U S A (2006) 2.81

The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation. J Bacteriol (2008) 2.39

A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway. J Biol Chem (2005) 2.18

Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate. Biochemistry (2007) 2.09

Genetic analysis of the beta-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to beta-lactam antibiotics. Microbiology (2005) 2.04

Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery. Cell (2014) 1.97

Distinct pathways for modification of the bacterial cell wall by non-canonical D-amino acids. EMBO J (2011) 1.94

The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin. Nat Med (2010) 1.91

Occurrence of D-alanyl-(D)-meso-diaminopimelic acid and meso-diaminopimelyl-meso-diaminopimelic acid interpeptide linkages in the peptidoglycan of Mycobacteria. Biochemistry (1974) 1.79

Crystal structure of a novel beta-lactam-insensitive peptidoglycan transpeptidase. J Mol Biol (2006) 1.76

Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies. BMC Biotechnol (2009) 1.56

B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymes. Proteins (2006) 1.47

Identification of the L,D-transpeptidases responsible for attachment of the Braun lipoprotein to Escherichia coli peptidoglycan. J Bacteriol (2007) 1.43

A periplasmic reducing system protects single cysteine residues from oxidation. Science (2009) 1.42

Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes. J Biol Chem (2007) 1.34

Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis. Mol Microbiol (2012) 1.30

Identification of the L,D-transpeptidases for peptidoglycan cross-linking in Escherichia coli. J Bacteriol (2008) 1.29

Balance between two transpeptidation mechanisms determines the expression of beta-lactam resistance in Enterococcus faecium. J Biol Chem (2002) 1.26

The peptidoglycan of Mycobacterium abscessus is predominantly cross-linked by L,D-transpeptidases. J Bacteriol (2010) 1.23

In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems. Antimicrob Agents Chemother (2013) 1.17

Clostridium difficile has an original peptidoglycan structure with a high level of N-acetylglucosamine deacetylation and mainly 3-3 cross-links. J Biol Chem (2011) 1.17

Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2. Structure (2012) 1.10

Essential metabolites of Mycobacterium tuberculosis and their mimics. MBio (2011) 1.04

In vitro antimycobacterial activity of 5-chloropyrazinamide. Antimicrob Agents Chemother (1998) 1.03

Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains. Acta Crystallogr D Biol Crystallogr (2013) 1.00

Structures of free and inhibited forms of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr (2013) 0.96

Phenotypic analysis of Eschericia coli mutants lacking L,D-transpeptidases. Microbiology (2013) 0.91

Nonclassical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, the cytosolic matrix, protein localization, virulence, and resistance to β-lactams. J Bacteriol (2014) 0.90

Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis. Cell Res (2013) 0.89

A role for the class A penicillin-binding protein PonA2 in the survival of Mycobacterium smegmatis under conditions of nonreplication. J Bacteriol (2010) 0.87

Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr (2013) 0.87

Peptidoglycan cross-linking in glycopeptide-resistant Actinomycetales. Antimicrob Agents Chemother (2014) 0.85

Domain Interaction Footprint: a multi-classification approach to predict domain-peptide interactions. Bioinformatics (2009) 0.83

Genetic characterization of mycobacterial L,D-transpeptidases. Microbiology (2014) 0.80