Published in J Biol Chem on August 24, 2015
New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria. Front Microbiol (2017) 0.79
LdtMav2, a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems. Future Microbiol (2017) 0.77
Mycobacterium abscessus L,D-transpeptidases are susceptible to inactivation by carbapenems and cephalosporins but not penicillins. Antimicrob Agents Chemother (2017) 0.75
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46
Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr (2011) 67.55
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62
Inference of macromolecular assemblies from crystalline state. J Mol Biol (2007) 44.95
ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics (1999) 21.85
Serine beta-lactamases and penicillin-binding proteins. Annu Rev Microbiol (1991) 6.63
An outbreak involving extensive transmission of a virulent strain of Mycobacterium tuberculosis. N Engl J Med (1998) 6.60
Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science (2009) 3.73
A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2003) 3.70
Structural modifications in the peptidoglycan of Escherichia coli associated with changes in the state of growth of the culture. J Bacteriol (1985) 2.96
Three-dimensional structure of the bacterial cell wall peptidoglycan. Proc Natl Acad Sci U S A (2006) 2.81
The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation. J Bacteriol (2008) 2.39
A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway. J Biol Chem (2005) 2.18
Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate. Biochemistry (2007) 2.09
Genetic analysis of the beta-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to beta-lactam antibiotics. Microbiology (2005) 2.04
Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery. Cell (2014) 1.97
Distinct pathways for modification of the bacterial cell wall by non-canonical D-amino acids. EMBO J (2011) 1.94
The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin. Nat Med (2010) 1.91
Occurrence of D-alanyl-(D)-meso-diaminopimelic acid and meso-diaminopimelyl-meso-diaminopimelic acid interpeptide linkages in the peptidoglycan of Mycobacteria. Biochemistry (1974) 1.79
Crystal structure of a novel beta-lactam-insensitive peptidoglycan transpeptidase. J Mol Biol (2006) 1.76
Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies. BMC Biotechnol (2009) 1.56
B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymes. Proteins (2006) 1.47
Identification of the L,D-transpeptidases responsible for attachment of the Braun lipoprotein to Escherichia coli peptidoglycan. J Bacteriol (2007) 1.43
A periplasmic reducing system protects single cysteine residues from oxidation. Science (2009) 1.42
Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes. J Biol Chem (2007) 1.34
Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis. Mol Microbiol (2012) 1.30
Identification of the L,D-transpeptidases for peptidoglycan cross-linking in Escherichia coli. J Bacteriol (2008) 1.29
Balance between two transpeptidation mechanisms determines the expression of beta-lactam resistance in Enterococcus faecium. J Biol Chem (2002) 1.26
The peptidoglycan of Mycobacterium abscessus is predominantly cross-linked by L,D-transpeptidases. J Bacteriol (2010) 1.23
In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems. Antimicrob Agents Chemother (2013) 1.17
Clostridium difficile has an original peptidoglycan structure with a high level of N-acetylglucosamine deacetylation and mainly 3-3 cross-links. J Biol Chem (2011) 1.17
Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2. Structure (2012) 1.10
Essential metabolites of Mycobacterium tuberculosis and their mimics. MBio (2011) 1.04
In vitro antimycobacterial activity of 5-chloropyrazinamide. Antimicrob Agents Chemother (1998) 1.03
Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains. Acta Crystallogr D Biol Crystallogr (2013) 1.00
Structures of free and inhibited forms of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr (2013) 0.96
Phenotypic analysis of Eschericia coli mutants lacking L,D-transpeptidases. Microbiology (2013) 0.91
Nonclassical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, the cytosolic matrix, protein localization, virulence, and resistance to β-lactams. J Bacteriol (2014) 0.90
Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis. Cell Res (2013) 0.89
A role for the class A penicillin-binding protein PonA2 in the survival of Mycobacterium smegmatis under conditions of nonreplication. J Bacteriol (2010) 0.87
Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr (2013) 0.87
Peptidoglycan cross-linking in glycopeptide-resistant Actinomycetales. Antimicrob Agents Chemother (2014) 0.85
Domain Interaction Footprint: a multi-classification approach to predict domain-peptide interactions. Bioinformatics (2009) 0.83
Genetic characterization of mycobacterial L,D-transpeptidases. Microbiology (2014) 0.80
Non-classical transpeptidases yield insight into new antibacterials. Nat Chem Biol (2016) 0.87
Mutation in an unannotated protein confers carbapenem resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother (2017) 0.75
HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity. Nat Struct Mol Biol (2017) 0.75
Mycobacterium abscessus L,D-transpeptidases are susceptible to inactivation by carbapenems and cephalosporins but not penicillins. Antimicrob Agents Chemother (2017) 0.75
Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis. Antimicrob Agents Chemother (2017) 0.75
Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem. BMC Biochem (2017) 0.75